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Chemistry World September 13, 2012 Ian Le Guillou	Hope for autism treatments Two reports in Science over the past week point the way to potential treatments for some forms of autism.
Chemistry World November 16, 2006 Simon Hadlington	Gene-Reading Enzyme Catapulted by Scrunch Power Two teams of researchers have solved a conundrum that has baffled molecular biologists for 20 years -- how the enzyme responsible for `reading' genes can release itself from the portion of DNA to which it initially binds extremely tightly.
Chemistry World February 18, 2008 John Bonner	Flicking the Acetyl Switch A strain of Escherichia coli that can produce proteins containing an acetylated version of the amino acid lysine could help to reveal how acetylation changes the function of hundreds of proteins inside cells.
Chemistry World December 21, 2006 Henry Nicholls	Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World May 26, 2010 Phillip Broadwith	Pain target enzyme's working made crystal clear An enzyme that influences how we feel pain and is a potential target for treating anxiety has been crystallised and its structure solved by US scientists.
Chemistry World March 8, 2007 Simon Hadlington	Researchers Claim Antibiotic Holy Grail Researchers in Canada have revealed the structure of a key enzyme involved in the synthesis of bacterial cell walls. The finding opens up the possibility of developing new and improved antibiotics and overcoming the increasing problem of bacterial resistance to existing drugs.
Chemistry World August 2, 2011 Phillip Broadwith	Protein synthesis hijacked to turn out cyclic peptides Japanese researchers have developed a way of reprogramming the genetic code and using bacteria to make and screen huge libraries of cyclic peptides using unnatural amino acids.
Chemistry World November 4, 2010 Laura Howes	Blocking cancer drug's toxic side effects US researchers have identified a compound that could drastically reduce toxic side effects associated with a widely used cancer drug.
Chemistry World November 18, 2010 Hayley Birch	'Hunger hormone' activating enzyme holds promise as obesity target Blocking a key gut enzyme involved in the hunger response can reduce weight gain in mice, say US and Taiwanese researchers. The approach could eventually lead to treatments for obesity in humans that would work by damping down hunger pangs.
Chemistry World August 29, 2007 Ananyo Bhattacharya	'Lost' Folate Enzyme Found After 30 Years US researchers have revealed the identity of an enzyme used by bacteria to make the essential B vitamin folate, 30 years after it was first isolated.
HHMI Bulletin Nov 2011 Dave Mosher	A New PACE for Laboratory Evolution Researchers have found a way to accelerate evolution of molecules by harnessing viruses.
Chemistry World November 6, 2009 Simon Hadlington	Boron-based compounds inhibit key HIV enzyme Researchers in the Czech Republic have shown that an unusual class of boron-containing compound can inhibit HIV protease, a key enzyme involved in replicating the virus that causes Aids.
HHMI Bulletin Winter 2013 Olga Kuchment	Rickety for a Reason Imagine walking inside a building so flimsy that it shakes with every step, making you wonder what keeps it standing. HHMI early career scientist Sin Urban has been asking the same question about an unusual class of enzymes, the rhomboid proteases.
Chemistry World October 31, 2008 Manisha Lalloo	DNA-rewinding protein discovered US scientists have found an enzyme that rewinds sections of DNA whose strands have mistakenly come apart.
Chemistry World August 5, 2011 David Bradley	Filming the roundabout production of cells' chemical fuel Japanese researchers have used a high-speed atomic force microscopy to shoot a movie of the tiny rotating enzyme that produces the chemical fuel for cells.
Chemistry World January 8, 2008 James Mitchell Crow	Amber Contains Hint of Paris's Tropical Past Scientists in France studying a local deposit of 55 million-year-old amber have unexpectedly isolated a natural product never seen before.
Chemistry World August 13, 2009 Simon Hadlington	Forcing enzyme activity New research has shown that physically stretching an enzyme can trigger its activity - even when the active site is not hidden in a 'cryptic' position. Mechanical force may play a more important role in biological molecular systems than previously realized.
Chemistry World October 5, 2006 Mark Peplow	Boron Shows Its Negative Side A molecule that hosts a negatively-charged boron atom could prove to be an exciting addition to the chemist's toolbox, according to researchers who have isolated the anion as its lithium salt.
Chemistry World May 12, 2008 Simon Hadlington	'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria.
Chemistry World April 15, 2010 Simon Hadlington	Lead joins the aromatic ring club Scientists in Japan have successfully incorporated an atom of lead into an aromatic molecule - the heaviest metal so far to be 'aromatised'.
Chemistry World February 3, 2013 Andy Extance	Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores.
Chemistry World December 12, 2006 Michael Gross	Ancient Protein Moonlights in the Eye A structural protein in the mouse eye lens is the evolutionary descendant of an ancient bacterial enzyme, researchers have found -- suggesting that moonlighting saved the protein from oblivion when its original role was taken over by a different family of enzymes.
Chemistry World September 9, 2007 Simon Hadlington	Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs.
Chemistry World June 23, 2015 Derek Lowe	Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example.
Chemistry World September 24, 2007 Simon Hadlington	Viral Nanoreactor Captures Single Molecules Researchers in the Netherlands have created a biochemical nanoreactor by cracking open a virus, removing its contents then reassembling the virus's protein coat around a single molecule of enzyme.
Chemistry World November 6, 2009 Phillip Broadwith	Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before.
Chemistry World April 12, 2007 Simon Hadlington	Fatty Acid Factory Revealed X-ray crystallographers have achieved the Herculean task of elucidating the architecture of one of biochemistry's most impressive molecular machines, the multi-enzyme fatty acid synthase.
Chemistry World July 15, 2010 Simon Hadlington	Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.
HHMI Bulletin February 2011 Mitzi Baker	When Worlds Collide The right time and place led to a new RNAi-like pathway in bacteria for biochemist Jennifer Doudna and geobiologist Jill Banfield.
Chemistry World September 24, 2012 Samantha Cheung	Tumors reprogram nylon synthesis Cancer mutations have inspired a redesign of an enzyme to catalyze a key step in the bio-based production of adipic acid, a precursor to nylon.
Chemistry World July 9, 2009 Andy Extance	Detailed crystal structure raises antibiotic hopes Scientists at King's College London and St. George's, University of London, have shown exactly how quinolones, which are the second line of defense against diseases like pneumonia and meningitis, interact with their topoisomerase IV enzyme target.
Chemistry World August 17, 2011 Josh Howgego	Worms Modified to Express Unnatural Amino Acids Unnatural amino acids have been expressed for the first time in complex multicellular organisms. Researchers hope this will open up new ways to track biochemical processes and disease pathways.
Chemistry World March 16, 2015 Elisabeth Ratcliffe	Enzyme selectivity switch to benefit infant formula production Scientists in Austria who have redesigned the active site of an enzyme to switch its regioselectivity may have latched onto a new way to make molecules that are important for infant formula.
HHMI Bulletin May 2010 Kendall Powell	Malaria's Weakness With different approaches, two HHMI researchers land on an enzyme critical to the malaria parasite's destructive ways.
Chemistry World August 30, 2007 James Mitchell Crow	Toxins' Synthesis Secret Cracked US chemists have discovered that using water instead of organic solvents is the key to understanding how algae make toxins called ladder polyethers.
Chemistry World November 27, 2011 James Mitchell Crow	Artificial enzymes close in on nature A synthetic metalloprotein that approaches the catalytic performance of a natural enzyme, despite its stripped-down structure, has been developed by a team of chemists in the US.
Chemistry World April 21, 2010 Simon Hadlington	Methane oxidising enzyme mystery solved The finding could lead to a cost-effective and environmentally clean method of methanol production for fuel and feedstock.
AskMen.com Jeff Bayer	Amino Acids The importance of amino acids can be overlooked at times, and severe problems can occur if you suffer from amino acid deficiency.
Chemistry World June 14, 2012 David Bradley	Tripling up on boron bonds Carbon and nitrogen are well known for their triple bonds, but making stable compounds with a triple bond between two boron atoms hadn't been achieved despite the computational possibilities. Until now.
Chemistry World June 17, 2010 Andrew Turley	Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy.
Chemistry World March 6, 2008 Simon Hadlington	Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch.
Chemistry World October 31, 2013 Derek Lowe	Natural born chemists Organic chemists may not seem like a humble group. But we should be, because we are humiliated every hour of the day by what nature accomplishes through enzyme catalysis.
Chemistry World February 6, 2012 David Bradley	10 out of 10 for boron's coordinated effort A team in the US has created a boron compound that has the highest coordination number of any planar species, squeezing 10 spoke-like bonds from a central metal hub to 10 boron atoms equally spaced around a nanoscopic wheel.
Chemistry World November 24, 2014 Jennifer Newton	Boron and beryllium finally shake hands Beryllium bis(diazaborolyl) features the first non-cluster bond between boron and beryllium.
Chemistry World June 9, 2013 James Urquhart	Hairy proteins survive stomach trip Swiss researchers have discovered a way to stabilize enzymes in the digestive tract by linking polymers to the enzymes.
Chemistry World January 17, 2010 Simon Hadlington	Sugars synthesised with help of promiscuous enzyme European researchers have discovered a new way to make synthetically elusive sugar molecules that could lead to novel vaccine candidates and other medically important compounds.
Chemistry World March 20, 2007 Lionel Milgrom	Chemical Model Unlocks Key Enzyme's Secrets The precise workings of cytochrome c oxidase (CcO), an enzyme that is crucial for all aerobic life, have been unveiled.
Chemistry World March 31, 2009 Jon Cartwright	Blood clotting light work for new molecule The molecule, which works with the help of an enzyme, could one day be used in medicine to shut off blood supply to localized areas of the human body such as tumors.
Managed Care June 2004 Thomas Morrow	Laronidase Opens Door To Treat Other Rare Disorders The release of alpha-L-iduronidase also demonstrates the wave of future treatments for many other mucopolysaccharidosis (MPS) diseases.