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Chemistry World January 6, 2010 Phillip Broadwith	Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain.
Chemistry World February 21, 2007 Tom Westgate	Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.
Chemistry World October 2008 Derek Lowe	Column: In the pipeline The author seeks a cure for 'compound bloat'
Chemistry World June 23, 2015 Derek Lowe	Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example.
Chemistry World April 2011	Molecular Obesity is Weighing Down Drug Discovery Medicinal chemistry's quest for potent drug candidates has resulted in molecules that are too large and too lipophilic for their own good.
Chemistry World June 2008 Sarah Houlton	Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success
Chemistry World June 5, 2012 Simon Perks	Chiral separation with micro-flows How do you separate enantiomers without any kind of chiral recognition between molecules? The answer it seems is to use asymmetric flow in a micro-fluidic channel.
Chemistry World August 26, 2008	Photonic crystal drug detective A new high-throughput screening system based on photonic crystals could quickly and cheaply detect molecules that disrupt binding between proteins and DNA.
Chemistry World December 2008	Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.
Chemistry World April 2, 2009 Ned Stafford	Fluorescent probes take screening to next level Researchers have developed a new high-throughput screening technique that could shed light on the biochemical activities of numerous proteins about which little is currently known.
Reactive Reports May 2007 David Bradley	Meeting of Molecular Movie Stars New footage confirms Linus Pauling's theory of chemical bonding proposed half a century ago, and could help explain molecular recognition processes important throughout supramolecular chemistry and molecular biology.
Chemistry World July 2010	Column: In the pipeline Derek Lowe ponders the possibility of phosphatase inhibitors
Chemistry World March 28, 2007 Victoria Gill	New Limits Set on Chirality Researchers have set a new standard in stereochemistry. Measuring Raman optical activity, they have confirmed the spatial arrangement of a molecule with almost impossibly subtle chirality: (R)-[ 2H 1, 2H 2, 2H 3]-neopentane.
Chemistry World January 2011	Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained.
Chemistry World March 2, 2007 Philip Ball	Giving Life a Hand Why are proteins left-handed and nucleic acids right-handed? Once offered only a few sketchy theories, scientists have found more alternatives for creating homochirality.
Chemistry World July 26, 2012 Derek Lowe	Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time.
Technology Research News March 23, 2005	Nanowires track molecular activity Researchers from Harvard University have found a way to use transistors made from silicon nanowires to gain information about how small molecules bind to proteins.
Chemistry World May 26, 2010 Phillip Broadwith	Pain target enzyme's working made crystal clear An enzyme that influences how we feel pain and is a potential target for treating anxiety has been crystallised and its structure solved by US scientists.
Chemistry World September 9, 2007 Simon Hadlington	Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs.
Chemistry World May 24, 2013 David Bradley	Microwaves show their hand The chirality of a gas phase molecule held in an electric field can be revealed using microwave spectroscopy. Hooking the technique to a separation step might even be exploited to isolate a specific enantiomer from a racemic mixture of both forms.
Chemistry World December 2007 Derek Lowe	Column: In the Pipeline The challenge of biologics.
Reactive Reports Issue 41 David Bradley	Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip.
Bio-IT World April 16, 2004 Malorye Branca	Finding the Perfect Fit Fragment-based drug discovery is unique and effective.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World May 20, 2015 Katrina Kramer	Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs.
Chemistry World March 4, 2015 Philip Ball	Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all.
Chemistry World October 2010	Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery
Technology Research News March 24, 2004	DNA has nano building in hand Researchers from Ludwig Maximilians University in Germany have built a simple molecular machine from DNA that can bind to and release single molecules of a specific type of protein.
Chemistry World May 31, 2009 Nina Notman	The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used.
Chemistry World February 8, 2006 Jon Evans	To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space.
Bio-IT World April 16, 2004 Kevin Davies	The Matrix Revolutions Serenex, a company dedicated to drug discovery, uses a proprietary matrix, or affinity media, to bind purine-binding protiens - a process that could transform the drug discovery business.
Chemistry World May 15, 2012 Harriet Brewerton	Chiral Confusion Scientists in Israel have shown that non-biological chiral crystals are much more abundant than previously thought and their findings could clear up a possible confusion over the term 'chiral'.
Chemistry World November 8, 2012 Laura Howes	Self-tying trefoil knot If knotting up molecules is so difficult why not take a tip from nature and get the molecules to do the work for you? This is what Cambridge University researchers found when one of their molecules did indeed tie itself in knots.
Chemistry World March 2012	Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug
Chemistry World December 10, 2008 Simon Hadlington	Alcohol enantiomer conundrum cracked UK chemists have discovered a straightforward new way to make chiral tertiary alcohols that gives selective access to either enantiomer.
Chemistry World August 2009 Derek Lowe	Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder
The Motley Fool September 21, 2006 Jack Uldrich	Harris & Harris Looks to Separate New technology could lead to safer, more effective drugs. Because of proprietary reasons, it's unlikely that ENS will be able to publicly announce when Big Pharma companies have licensed its technology, but Harris & Harris investors have reason to be optimistic.
Chemistry World March 5, 2015 Emma Stoye	Forgotten synthetic PhD theses set to be given new lease of life A team of researchers have amassed a digital collection of more than 75,000 compounds from PhD theses that might otherwise have mouldered in obscurity.
Chemistry World July 26, 2007 Tom Westgate	Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds.
Chemistry World November 30, 2012 Andy Extance	Chemists cull compounds using 'intuition' Medicinal chemists might be using far fewer parameters to choose candidate fragments for a screening collection than they think they do. Their choices can be mimicked based on just one or two properties, a team led by researchers at Swiss-headquarted pharmaceutical firm Novartis has found.
Chemistry World November 25, 2014 James Urquhart	Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions.
Chemistry World July 16, 2013 Harriet Brewerton	Accelerating stereochemical analysis A chemosensor has been developed by scientists in the US to speed up the quantitative stereochemical analysis of chiral amino alcohols and diamines.
Chemistry World February 3, 2010 Simon Hadlington	New 'hook' for reversibly binding molecules to proteins UK chemists have found a simple new 'hook' that allows molecules to be attached to proteins and later removed, something that is currently difficult to achieve.
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World September 18, 2013 Phillip Broadwith	Service with a smile Contract organic synthesis is a competitive business. Service companies in China and India offer their skills at prices it can be difficult for western firms to compete with. So how does a company stand out from the crowd?
Chemistry World March 6, 2011 Mike Brown	Molecules that walk, hop and jump 'Two legged' molecules walk, hop and fly across a receptor surface, according to researchers in the Netherlands and Ireland. The findings could help us understand how viruses and bacteria interact with cell membranes, they say.
Chemistry World October 17, 2011 Andy Extance	Water erodes 'lock and key' drug model US researchers have dealt a severe blow to the idea of a single 'hydrophobic effect' that can help explain how all drugs dock with proteins.
Chemistry World March 9, 2006 Katharine Sanderson	Covalent Bonds Crack Under the Strain Chemists must consider engineering principles when designing molecules following news that tough carbon-to-carbon bonds break easily under mechanical strain.
Chemistry World September 6, 2013 Melissae Fellet	Unravelling stereochemistry via mass spectrometry Researchers have used mass spectrometry to determine the stereochemistry of a prototypical chiral molecule, CHBrClF.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.