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Chemistry World
September 20, 2007
Lewis Brindley
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
February 21, 2007
Tom Westgate
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. mark for My Articles similar articles
Chemistry World
October 2009
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions mark for My Articles similar articles
Chemistry World
February 2011
Paul Docherty
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw. mark for My Articles similar articles
Chemistry World
January 19, 2010
Simon Hadlington
New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions. mark for My Articles similar articles
Chemistry World
February 2011
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential mark for My Articles similar articles
Chemistry World
September 24, 2009
Phillip Broadwith
Carbon can't but tin can US chemists have discovered that distannynes - tin-based analogues of acetylenes - can react reversibly with ethene to make cyclic complexes. mark for My Articles similar articles
Chemistry World
January 5, 2011
Akshat Rathi
Macromolecules from miniature templates UK researchers have designed a new highly effective method to construct large molecules of a defined size using simple templates. mark for My Articles similar articles
Chemistry World
November 25, 2014
James Urquhart
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. mark for My Articles similar articles
Chemistry World
January 6, 2010
Phillip Broadwith
Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. mark for My Articles similar articles
Chemistry World
July 30, 2014
Psylloborine A It's a somewhat surprising assertion that almost a fifth of natural products are thought to include a dimerization step somewhere in their biosynthesis. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Chemistry World
December 2, 2008
James Mitchell Crow
Just add air for cleaner carbon bonding UK scientists have found a new way to clip together organic molecules that could be the ultimate green approach to making carbon-carbon bonds mark for My Articles similar articles
Chemistry World
January 17, 2014
Phillip Broadwith
Plug and play redox enzymes With the constant drive to make chemical synthesis ever cleaner, more energy-efficient and generate less waste -- both in research and industrial processes -- more and more chemists are looking to harness enzyme catalysis. mark for My Articles similar articles
Chemistry World
January 25, 2007
Richard Van Noorden
Water Surprise for Atmospheric Scientists Lone water molecules can catalyze reactions between atmospheric gases, scientists have confirmed, throwing a wrench in the works of supposedly simple atmospheric chemistry. mark for My Articles similar articles
Reactive Reports
Issue 63
David Bradley
Chemists Go Round the Bend Chemists often think of molecular wires as "shape-persistent" rods with limited flexibility, but researchers have now shown that molecular wires can be bent into ring shapes. mark for My Articles similar articles
Chemistry World
April 14, 2009
Lewis Brindley
Osmium and pyridine ring together Organic chemists in China have found a way to put osmium into a pyridine ring - leading to the synthesis of the first metallapyridinium complex. mark for My Articles similar articles
Chemistry World
December 21, 2012
Laura Howes
Engineered enzyme performs cyclopropanation by carbene transfer While biomimetic chemistry has been busy learning from nature, other chemists have been busy modifying enzymes to develop biocatalysts for other reactions. mark for My Articles similar articles
Chemistry World
March 31, 2009
Lewis Brindley
Giving molecules a stretch A simple way to stretch small molecules and measure the forces at play has been developed by researchers in the US. mark for My Articles similar articles
Chemistry World
January 10, 2008
Jonathan Edwards
Textbook Reaction Has a Subtle Twist The SN2 bimolecular nucleophilic substitution, a textbook reaction fundamental to organic synthesis, has a subtle twist, according to researchers. mark for My Articles similar articles
Chemistry World
March 21, 2007
Richard Van Noorden
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
July 15, 2010
Simon Hadlington
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. mark for My Articles similar articles
Chemistry World
July 2007
Dylan Stiles
Opinion: Bench Monkey Synthesizing molecules that force atoms into bizarre contortionist acts is the only way to learn. mark for My Articles similar articles
Wired
Erin Biba
Molecular Frameworks, the Building Blocks of All Life The world is complicated, but not as complicated as you might think. Most organic molecules derive from a few relatively simple architectures. mark for My Articles similar articles
Chemistry World
July 13, 2015
Philip Ball
First snapshot of elusive intermediate supplies surprise A team near Zurich in Switzerland, has been able to take a single-molecule snapshot of an intermediate in a common class of organic reactions. mark for My Articles similar articles
Chemistry World
February 8, 2006
Jon Evans
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space. mark for My Articles similar articles
Chemistry World
September 12, 2010
Simon Hadlington
Isotope effect seen on single molecule The isotope effect - where the rate of a reaction is altered depending on the presence of a given isotopic atom in the reactant - is a key tool for elucidating reaction mechanisms mark for My Articles similar articles
Chemistry World
October 29, 2014
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others. mark for My Articles similar articles
Chemistry World
January 17, 2010
Simon Hadlington
Sugars synthesised with help of promiscuous enzyme European researchers have discovered a new way to make synthetically elusive sugar molecules that could lead to novel vaccine candidates and other medically important compounds. mark for My Articles similar articles
Chemistry World
September 2010
Paul Docherty
Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?' mark for My Articles similar articles
Chemistry World
June 23, 2015
Philip Ball
Ultra-bright x-rays film molecular reaction A team working at the Stanford Linear Collider in California claims to have made 'the first molecular movie' using ultra-fast x-ray scattering from molecules as they undergo a chemical reaction. mark for My Articles similar articles
Chemistry World
April 25, 2014
Derek Lowe
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. mark for My Articles similar articles
Technology Research News
June 29, 2005
Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined. mark for My Articles similar articles
Chemistry World
March 22, 2012
Ross McLaren
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. mark for My Articles similar articles
Chemistry World
May 21, 2015
Simon Hadlington
Molecular pump points way to non-equilibrium chemistry Researchers in the US have developed an artificial molecular pump which can accumulate small, highly charged molecules against a concentration gradient. mark for My Articles similar articles
Chemistry World
November 2007
Derek Lowe
Column: In the Pipeline Chemists are finally going with the flow. mark for My Articles similar articles
Chemistry World
March 6, 2008
Simon Hadlington
Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch. mark for My Articles similar articles
Chemistry World
September 24, 2007
Simon Hadlington
Viral Nanoreactor Captures Single Molecules Researchers in the Netherlands have created a biochemical nanoreactor by cracking open a virus, removing its contents then reassembling the virus's protein coat around a single molecule of enzyme. mark for My Articles similar articles
Chemistry World
November 6, 2009
Phillip Broadwith
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. mark for My Articles similar articles
Chemistry World
September 28, 2015
Karl Collins
A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research. mark for My Articles similar articles
Chemistry World
October 12, 2006
Richard Van Noorden
Lasers on the Energy Ski Slope Researchers have shown that intense laser-light pulses can act as catalysts, controlling the end products of a chemical reaction without themselves being absorbed. mark for My Articles similar articles
Chemistry World
September 26, 2012
Derek Lowe
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run? mark for My Articles similar articles
Chemistry World
March 16, 2011
Laura Howes
The explosive potential of nitrogen compounds Two separate groups have looked at the explosive potential of nitrogen compounds but while one group made an incredibly explosive compound, the others have developed a safer synthetic route for tetrazoles. mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C. P. Williams
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. mark for My Articles similar articles
Chemistry World
November 26, 2012
Laura Howes
Protein coat prepares catalyst for cascades By protecting a transition metal catalyst with a protein coat, scientists have managed to couple up biocatalysts and chemical catalysts to perform a cascade reaction. mark for My Articles similar articles
Chemistry World
September 9, 2007
Simon Hadlington
Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs. mark for My Articles similar articles
Chemistry World
January 17, 2014
Katia Moskvitch
Life may have begun in a tiny water droplet Chemical reactions run much faster and more efficiently when they take place in tiny droplets rather than in freestanding water -- such as a puddle or a lake, say researchers. mark for My Articles similar articles