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Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World February 21, 2007 Tom Westgate |
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World February 2011 Paul Docherty |
Column: Totally Synthetic Although most of the natural products I've discussed have had biological activity at the core of the rationale for their synthesis, most organic chemists will admit that an unusual chemical structure is by far the stronger draw. |
Chemistry World January 19, 2010 Simon Hadlington |
New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions. |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential |
Chemistry World September 24, 2009 Phillip Broadwith |
Carbon can't but tin can US chemists have discovered that distannynes - tin-based analogues of acetylenes - can react reversibly with ethene to make cyclic complexes. |
Chemistry World January 5, 2011 Akshat Rathi |
Macromolecules from miniature templates UK researchers have designed a new highly effective method to construct large molecules of a defined size using simple templates. |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World January 6, 2010 Phillip Broadwith |
Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. |
Chemistry World July 30, 2014 |
Psylloborine A It's a somewhat surprising assertion that almost a fifth of natural products are thought to include a dimerization step somewhere in their biosynthesis. |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Chemistry World December 2, 2008 James Mitchell Crow |
Just add air for cleaner carbon bonding UK scientists have found a new way to clip together organic molecules that could be the ultimate green approach to making carbon-carbon bonds |
Chemistry World January 17, 2014 Phillip Broadwith |
Plug and play redox enzymes With the constant drive to make chemical synthesis ever cleaner, more energy-efficient and generate less waste -- both in research and industrial processes -- more and more chemists are looking to harness enzyme catalysis. |
Chemistry World January 25, 2007 Richard Van Noorden |
Water Surprise for Atmospheric Scientists Lone water molecules can catalyze reactions between atmospheric gases, scientists have confirmed, throwing a wrench in the works of supposedly simple atmospheric chemistry. |
Reactive Reports Issue 63 David Bradley |
Chemists Go Round the Bend Chemists often think of molecular wires as "shape-persistent" rods with limited flexibility, but researchers have now shown that molecular wires can be bent into ring shapes. |
Chemistry World April 14, 2009 Lewis Brindley |
Osmium and pyridine ring together Organic chemists in China have found a way to put osmium into a pyridine ring - leading to the synthesis of the first metallapyridinium complex. |
Chemistry World December 21, 2012 Laura Howes |
Engineered enzyme performs cyclopropanation by carbene transfer While biomimetic chemistry has been busy learning from nature, other chemists have been busy modifying enzymes to develop biocatalysts for other reactions. |
Chemistry World March 31, 2009 Lewis Brindley |
Giving molecules a stretch A simple way to stretch small molecules and measure the forces at play has been developed by researchers in the US. |
Chemistry World January 10, 2008 Jonathan Edwards |
Textbook Reaction Has a Subtle Twist The SN2 bimolecular nucleophilic substitution, a textbook reaction fundamental to organic synthesis, has a subtle twist, according to researchers. |
Chemistry World March 21, 2007 Richard Van Noorden |
Forcing a Reaction US chemists have forced molecules to react by ripping their bonds apart with ultrasound. The scientists carefully stretched one targeted bond until it snapped, guiding the molecule's subsequent reaction into pathways forbidden by conventional chemistry. |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. |
Chemistry World July 2007 Dylan Stiles |
Opinion: Bench Monkey Synthesizing molecules that force atoms into bizarre contortionist acts is the only way to learn. |
Wired Erin Biba |
Molecular Frameworks, the Building Blocks of All Life The world is complicated, but not as complicated as you might think. Most organic molecules derive from a few relatively simple architectures. |
Chemistry World July 13, 2015 Philip Ball |
First snapshot of elusive intermediate supplies surprise A team near Zurich in Switzerland, has been able to take a single-molecule snapshot of an intermediate in a common class of organic reactions. |
Chemistry World February 8, 2006 Jon Evans |
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space. |
Chemistry World September 12, 2010 Simon Hadlington |
Isotope effect seen on single molecule The isotope effect - where the rate of a reaction is altered depending on the presence of a given isotopic atom in the reactant - is a key tool for elucidating reaction mechanisms |
Chemistry World October 29, 2014 |
Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others. |
Chemistry World January 17, 2010 Simon Hadlington |
Sugars synthesised with help of promiscuous enzyme European researchers have discovered a new way to make synthetically elusive sugar molecules that could lead to novel vaccine candidates and other medically important compounds. |
Chemistry World September 2010 Paul Docherty |
Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?' |
Chemistry World June 23, 2015 Philip Ball |
Ultra-bright x-rays film molecular reaction A team working at the Stanford Linear Collider in California claims to have made 'the first molecular movie' using ultra-fast x-ray scattering from molecules as they undergo a chemical reaction. |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. |
Technology Research News June 29, 2005 |
Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined. |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. |
Chemistry World May 21, 2015 Simon Hadlington |
Molecular pump points way to non-equilibrium chemistry Researchers in the US have developed an artificial molecular pump which can accumulate small, highly charged molecules against a concentration gradient. |
Chemistry World November 2007 Derek Lowe |
Column: In the Pipeline Chemists are finally going with the flow. |
Chemistry World March 6, 2008 Simon Hadlington |
Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch. |
Chemistry World September 24, 2007 Simon Hadlington |
Viral Nanoreactor Captures Single Molecules Researchers in the Netherlands have created a biochemical nanoreactor by cracking open a virus, removing its contents then reassembling the virus's protein coat around a single molecule of enzyme. |
Chemistry World November 6, 2009 Phillip Broadwith |
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. |
Chemistry World September 28, 2015 Karl Collins |
A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research. |
Chemistry World October 12, 2006 Richard Van Noorden |
Lasers on the Energy Ski Slope Researchers have shown that intense laser-light pulses can act as catalysts, controlling the end products of a chemical reaction without themselves being absorbed. |
Chemistry World September 26, 2012 Derek Lowe |
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run? |
Chemistry World March 16, 2011 Laura Howes |
The explosive potential of nitrogen compounds Two separate groups have looked at the explosive potential of nitrogen compounds but while one group made an incredibly explosive compound, the others have developed a safer synthetic route for tetrazoles. |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. |
Chemistry World November 26, 2012 Laura Howes |
Protein coat prepares catalyst for cascades By protecting a transition metal catalyst with a protein coat, scientists have managed to couple up biocatalysts and chemical catalysts to perform a cascade reaction. |
Chemistry World September 9, 2007 Simon Hadlington |
Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs. |
Chemistry World January 17, 2014 Katia Moskvitch |
Life may have begun in a tiny water droplet Chemical reactions run much faster and more efficiently when they take place in tiny droplets rather than in freestanding water -- such as a puddle or a lake, say researchers. |