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Chemistry World November 28, 2006 Michael Gross	Synthesis Success After 30 Years Chemists at Harvard have succeeded in synthesizing the antibiotic moenomycin A from scratch. They hope that by providing easier access to this molecule and its variants, they might aid the development of new antibiotics based on its structure.
Chemistry World January 8, 2015 Matthew Gunther	New antibiotic could treat infection while dodging resistance problems A new antibiotic that can kill life-threatening bacteria -- without them appearing to be able to develop resistance to the drug -- has been discovered by a team of scientists.
Chemistry World February 11, 2011 Leanne Marle	Fighting back against antibiotic resistant bacteria Scientists in Japan have revealed how vancomycin dimers are effective against vancomycin-resistant bacteria.
Chemistry World December 4, 2009 Lewis Brindley	Potent two-pronged antibiotic provides hope for future drugs A two-headed compound obtained from soil bacteria may hold the key to developing the next generation of antibiotics, researchers in the UK report.
Chemistry World October 13, 2006 Richard Van Noorden	Fastest Synthesis in the West A promising antibiotic with a novel mechanism of action has been synthesized for the first time -- and with impressive speed.
Chemistry World July 15, 2010 Matt Wilkinson	Biotechs plot path of least resistance Biopharmaceutical companies are moving into antibiotics, and filling the void left by big pharma.
Chemistry World August 6, 2007 Tom Westgate	Unique Antibiotic Beats Superbugs' Resistance The discovery of how a unique antibiotic kills its targets has uncovered a new way to tackle resistant superbugs. A team of chemists and structural biologists have studied how the natural antibiotic lactivicin interacts with a crucial bacterial protein.
Chemistry World August 29, 2007 Ananyo Bhattacharya	'Lost' Folate Enzyme Found After 30 Years US researchers have revealed the identity of an enzyme used by bacteria to make the essential B vitamin folate, 30 years after it was first isolated.
Chemistry World December 12, 2006 Michael Gross	Ancient Protein Moonlights in the Eye A structural protein in the mouse eye lens is the evolutionary descendant of an ancient bacterial enzyme, researchers have found -- suggesting that moonlighting saved the protein from oblivion when its original role was taken over by a different family of enzymes.
IEEE Spectrum February 2009 Monica Heger	Computer-Designed Drugs Could Thwart Antibiotic-Resistant Bacteria Researchers use computer algorithms to tweak enzymes that make antibiotics
Chemistry World March 8, 2013 Simon Hadlington	Battleground develops over antibiotic killing mechanism Two recent papers will require many in the field to re-examine and re-open the question of whether or not several different classes of bactericidal antibiotics do or do not work through a common mechanism.
HHMI Bulletin Nov 2010 Sarah C.P. Williams	A Study on Antibiotic Resistance Shows That Bacteria Aren't Just Out To Help Themselves Microbes that are resistant to the drug protect their weaker kin in the colony, HHMI researchers have found. The discovery upends traditional notions of antibiotic resistance and offers a target for new drugs against bacterial infections.
Chemistry World April 27, 2011 Carol Stanier	Drug cocktails greater than the sum of their parts Canadian scientists have shown that combining an antibiotic that is past its prime with other drugs can give it a new lease of life.
Chemistry World June 10, 2009 James Urquhart	Enzyme employs unusual cleavage reaction The mechanism of an unusual carbon bond cleavage reaction in the biosynthetic pathway of phosphinothricin tripeptide (PTT) - a naturally occurring herbicide and antibiotic compound - has been elucidated by US scientists
Chemistry World July 15, 2010 Simon Hadlington	Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit.
Chemistry World September 19, 2008 John Bonner	Filling the antibiotic gap Resistance to currently available antibacterial drugs is causing growing concern among doctors who find themselves unable to treat common infections
Chemistry World October 29, 2012 Harriet Brewerton	Prescription nanoreactors Scientists in Switzerland have developed a nanoreactor that can synthesize and release the antibiotic cephalexin, which is used to treat bacterial infections.
Chemistry World March 19, 2014 Emma Stoye	Molecular drill bits attack tuberculosis Peptides that punch through bacterial cell walls while leaving human cells unharmed could open up new ways to tackle antibiotic resistance, say researchers in the US.
Chemistry World August 11, 2011 Hayley Birch	'Dial a Molecule' Approach Controls Antibiotic Production Scientists have used genetic methods to control the chemical structures of pacidamycin antibiotics produced in bacteria. Their approach allows them to 'dial into' particular molecules, and to generate new pacidamycins.
Chemistry World March 13, 2013 Ned Stafford	Antibiotic resistance is a 'ticking time bomb' Global research efforts to develop new antibiotics need to be accelerated urgently, the UK government's chief medical officer has warned. She adds that that new drugs are desperately needed to fight the 'catastrophic threat' of growing antimicrobial resistance.
Chemistry World June 21, 2007 Simon Hadlington	Boron is Key to Antifungal Agent Researchers have shown that the presence of a boron atom is key to an antifungal agent being developed to treat infections of fingernails and toenails.
Chemistry World March 6, 2008 Simon Hadlington	Synthetic Enzymes Designed by Computer Scientists in the US have designed and built an artificial enzyme from scratch.
Chemistry World December 15, 2015 Michaela Muehlberg	Bacterial identification gets a culture shock Scientists in the UK have developed a new tool to distinguish bacterial strains from each other.
Chemistry World August 10, 2009 James Urquhart	Stretching for reversible enzyme activation A new kind of biologically inspired nanomaterial that can be chemically turned on and off by mechanical stretching has been devised by French researchers.
Chemistry World August 27, 2014 Richard Massey	Fluorinating new life into an increasingly ineffective antibiotic A fluorinated analog of the naturally occurring aminoglycoside neomycin -- well known as an over-the-counter ointment for minor skin abrasions -- could lead to a range of much-needed antibiotics
Chemistry World June 17, 2010 Andrew Turley	Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy.
Chemistry World June 28, 2013 Emma Stoye	Antibiotic killing mechanism debate continues Antibiotics can kill bacteria without the need for reactive oxygen species. That's the claim of new research, which has added new evidence into the emerging debate over how antibiotics exert their lethal effects.
Chemistry World March 16, 2015 Elisabeth Ratcliffe	Enzyme selectivity switch to benefit infant formula production Scientists in Austria who have redesigned the active site of an enzyme to switch its regioselectivity may have latched onto a new way to make molecules that are important for infant formula.
HHMI Bulletin Winter 2013 Olga Kuchment	Rickety for a Reason Imagine walking inside a building so flimsy that it shakes with every step, making you wonder what keeps it standing. HHMI early career scientist Sin Urban has been asking the same question about an unusual class of enzymes, the rhomboid proteases.
Chemistry World October 8, 2013 David Bradley	3D printing bacteria Jason Shear and colleagues at the University of Texas, US, have developed a 3D printing technique that lets them 'construct' defined bacterial communities so that short-range chemical communications and physical interactions between bacteria can be investigated more systematically than ever before.
Chemistry World September 9, 2007 Simon Hadlington	Sugaring the Pill Researchers in the US have made a key advance in efforts to bolt sugar molecules onto natural products in the search for new drugs.
Chemistry World April 12, 2007 Simon Hadlington	Fatty Acid Factory Revealed X-ray crystallographers have achieved the Herculean task of elucidating the architecture of one of biochemistry's most impressive molecular machines, the multi-enzyme fatty acid synthase.
Chemistry World May 12, 2011 Mike Brown	Sugars recruited in fight against persistent infections Adding sugar to antibiotics can boost their effectiveness and prevent recurrent and chronic infections, according to researchers in the US.
Fast Company May 2009 Elizabeth Svoboda	Biotechs Wage War on Superbugs With antibiotic resistance on the rise, three biotechs are developing new ways to wage war on superbugs.
Chemistry World November 5, 2013 Emma Stoye	Copper signals warn bacteria of antibiotic assault Copper is known for its antimicrobial properties, but new research suggests that copper signalling within bacterial cells may also play an important role in antibiotic resistance.
Chemistry World August 25, 2010 Phillip Broadwith	Antibiotic nanoparticles go for gold Chemists in the UK and India have developed a simple, one step synthesis of gold nanoparticles incorporating an antibiotic, without using any other chemicals.
Chemistry World November 27, 2011 James Mitchell Crow	Artificial enzymes close in on nature A synthetic metalloprotein that approaches the catalytic performance of a natural enzyme, despite its stripped-down structure, has been developed by a team of chemists in the US.
Chemistry World March 4, 2013 Harriet Brewerton	Co-factoring on a chip makes biocatalysis easy Stephan Mohr and colleagues have designed an efficient microfluidic biocatalysis device that uses and regenerates an artificial mediator, dimethyl viologen, which is cheaper than co-factors used currently.
Chemistry World January 17, 2010 Simon Hadlington	Sugars synthesised with help of promiscuous enzyme European researchers have discovered a new way to make synthetically elusive sugar molecules that could lead to novel vaccine candidates and other medically important compounds.
Chemistry World October 29, 2013 Harriet Brewerton	Paper device spots antibiotic-resistant bacteria Scientists in Canada have developed a paper-based device that checks if bacteria are resistant to certain antibiotics. The simple system could help users in remote areas.
Chemistry World February 25, 2014 Simon Hadlington	Synthetic 'textbook model' of a biological catalyst Scientists have developed a simple two-molecule chemical analogue of an enzyme and its substrate that neatly illustrates the fundamental principles of biological catalysis.
Chemistry World July 8, 2014 Anthony King	Call for new models to pay for antibiotics Governments will need to think seriously about changing the way they pay for the drugs. That's the conclusion of a report from the UK House of Commons science and technology committee.
Chemistry World October 14, 2008 Simon Hadlington	Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells.
Chemistry World April 14, 2006 Simon Hadlington	Deciphering Hydrogen Tunnelling in Enzymes Researchers have thrown important new light on the phenomenon of hydrogen tunnelling in biological catalysts. The finding is likely to spark a debate among biochemists about the fundamental nature of enzymes.
Chemistry World October 31, 2013 Derek Lowe	Natural born chemists Organic chemists may not seem like a humble group. But we should be, because we are humiliated every hour of the day by what nature accomplishes through enzyme catalysis.
Chemistry World January 6, 2010 Phillip Broadwith	Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain.
Reactive Reports March 2005 David Bradley	Microbial Manufacturing A bacterium is a microscopic chemical factory producing antibiotics, immunosuppressants, and anticancer drugs no chemist can synthesize. but pharmaceutical companies have been tapping into microbial drug manufacturing for some time.
Chemistry World May 6, 2014 Andy Extance	WHO raises alarm on deadly bacteria The World Health Organization has warned antibiotic resistant bacteria could bring a nightmarish future, where seemingly trivial scrapes turn lethal, and currently routine operations become too risky to contemplate.
Food Processing August 2007 Mark Anthony	Nutrition Beyond the Trends: Connecting the Dots on Enzymes Lactase -- an enzyme that splits lactose into its constituent sugars, glucose and galactose -- can make short work of the lactose intolerance problem.
Chemistry World June 9, 2013 James Urquhart	Hairy proteins survive stomach trip Swiss researchers have discovered a way to stabilize enzymes in the digestive tract by linking polymers to the enzymes.