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HHMI Bulletin Fall 2012 Halleh B. Balch	Like a Chinese Finger Trap In neurodegenerative diseases like Alzheimer's, the needle-like fibers that accumulate in the brain are not the real damage-doers. The culprits are intermediate protein structures, called small amyloid oligomers, made of a few proteins that misfold and aggregate.
Chemistry World April 2009 Philip Ball	Column: The crucible Unwinding protein fibrils could give a glimpse of how peptides survived on early Earth
Chemistry World June 14, 2009 Hayley Birch	New technique probes Alzheimer's aggregates US and UK researchers have used a new technique to identify what they think could be the primary toxic species in the development of Alzheimer's disease
Chemistry World November 2006 Philip Ball	Opinion: The Crucible Here are some of the latest instalments in the ongoing story of how protein misfolding causes neurodegenerative diseases -- a story that is not solely about developing clinical treatments or preventative medicines, but which goes to the heart of proteins' role as the stuff of life.
Chemistry World November 15, 2010 Manisha Lalloo	pH prompts protein structure US researchers studying the naturally-occurring amyloid protein Pmel17 have discovered that pH plays an important role in its structure, helping the body control its aggregation.
Reactive Reports Issue 51 David Bradley	Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique.
Chemistry World January 19, 2011 Jon Cartwright	Modified protein binders give shortcut to drugs The method, which involves attaching polypeptides to the binders, could help reduce the work required to develop protein binders into safer drugs.
Chemistry World September 12, 2014 Hayley Simon	Coated nanoparticles show Alzheimer's promise Nanoparticles coated in an amino acid polymer have been found to prevent the formation of amyloid fibrils -- incorrectly folded protein fibers associated with the development of neurodegenerative diseases.
Chemistry World June 14, 2011	A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World December 10, 2009 Phillip Broadwith	Solving fibril formation "It really is a case of the ideas of mathematics and physics helping us to understand chemistry and biology," says Chris Dobson of the University of Cambridge.
Chemistry World February 13, 2014 Philip Ball	Ice core to antifreeze protein's inner workings The antifreeze protein that protects the winter flounder from sub-zero temperatures has been found to have an odd structure.
Chemistry World May 9, 2007 James Mitchell Crow	Controlling prion folding US scientists report that prions, infamously linked to mad cow disease, have crucial subsections that control their behavior, including whether or not they can cross between species.
HHMI Bulletin May 2010 Richard Saltus	A Silver Lining Sure, some prions can cause diseases, but others are turning out to be beneficial.
Chemistry World December 19, 2007 Simon Hadlington	Snapshot of Proteins Linked to Autism Researchers in France and the US have caught on camera the gentle embrace between two proteins that sit on either side of the junction between nerve cells. It's this short circuit that has thought to cause some types of autism.
Chemistry World August 17, 2011 Jon Cartwright	Plasma Treatment to Use Patient's Proteins to Improve Medical Device Biocompatibility Researchers have developed a plasma treatment that can make any medical device biocompatible by sticking a patient's own proteins to it.
Chemistry World November 6, 2015 Emma Stoye	Eye drops show promise treating cataracts and even reversing damage A molecule that can bind and re-solubilize misfolded proteins in the eye has been identified by researchers in the US.
Chemistry World March 16, 2014 Simon Hadlington	Short peptides self-assemble into a catalyst Researchers in the US have created catalysts from peptide chains that are only seven amino acids long.
Chemistry World December 5, 2007 Ananyo Bhattacharya	Structural Snapshot Shows Monster Protein A structural snapshot of a protein capsule has revealed details of the largest cellular component ever imaged by x-ray crystallography.
Chemistry World August 24, 2009 Phillip Broadwith	'Chemical nose' sensor sniffs blood protein profile US scientists have developed a sensor system for profiling the protein content of human blood serum without needing individual receptors for each separate protein.
Chemistry World June 1, 2012 Simon Hadlington	Protein architecture with atomic precision Researchers have made a key breakthrough in designing and building geometrically defined nanostructures from proteins with unprecedented accuracy.
Wired January 18, 2008 Miyoko Ohtake	Fighting the Most Lethal Diseases With 3-D Snapshots of Their Pathogens If you can get a good look at the proteins, you can find places where other molecules can latch on and exterminate the bugs.
Chemistry World October 16, 2006 Michael Gross	Brief Encounter Observing fleeting interactions between molecules in solution requires extremely sophisticated methods. NMR spectroscopists have now developed tools that let them watch the transient encounter between two proteins before a well-defined complex is formed.
Chemistry World December 21, 2006 Tom Westgate	Molecular Probe Identifies Patients at Risk of Alzheimer's A new molecule could provide an early warning system for Alzheimer's disease, US researchers hope.
Chemistry World June 17, 2012 Jon Evans	Anti-social amino acids gang up Previously thought to be purely the preserve of proteins and peptides, scientists have discovered that the amino acid phenylalanine can form the toxic amyloid fibrils that are a hallmark of diseases such as Alzheimer's and Parkinson's.
Chemistry World November 13, 2014 Katrina Kramer	Persuading proteins to form porous polyhedra Researchers in the US have designed a hollow cube out of naturally occurring proteins, something that was previously only possible with DNA.
HHMI Bulletin Spring 2013 Nicole Kresge	A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology.
Chemistry World February 24, 2012 Simon Hadlington	Botox 'bodyguard' gives protein protection Researchers have discovered how one of the most potent toxins known to man can survive in the human stomach and digestive tract.
Chemistry World October 27, 2014 Tim Wogan	Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability.
Science News June 30, 2007 Janet Raloff	Infectious Foie Gras? Foie gras contains misfolded proteins that, when given to mice, trigger disease.
HHMI Bulletin Feb 2011	DNA Curtains How proteins behave in such a crash test gives scientists data about their structural integrity, how they attach to DNA, and how they behave in a cell.
Wired John Bohannon	Gamers Unravel the Secret Life of Protein A look at the protein chemistry world's biennial World Series, a competition to see who can predict the shape a protein will fold into, knowing nothing more than the sequence of its constituent parts.
Chemistry World September 21, 2006 Michael Gross	Alzheimer's Alphabet Alzheimer's researchers are now closer to understanding the natural function of one of the two enzymes that cut A out of APP, and have recreated the process by which fibril formation begins in vivo.
Technology Research News September 24, 2003 Kimberly Patch	Heated plastic holds proteins One important task for biochips is sorting proteins, but it's tricky business getting protein molecules to be where you want them and stay away from where you don't. A tiny, plastic-coated hot plate allows scientists to trap and release proteins on command.
HHMI Bulletin Winter 2013 Nicole Kresge	A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure.
Chemistry World July 20, 2009 Philip Ball	Researchers form first liquid protein Chemists at the University of Bristol, UK and their colleagues, in collaboration with the Max Planck Institute for Colloid and Interface Research in Golm, Germany, have figured out how to convert pure proteins into a liquid state, without any solvent.
Bio-IT World June 12, 2002 Mark D. Uehling	Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts?
Chemistry World January 9, 2013 Laura Howes	Antifreeze protein's watery dance Most animals left in -30 C temperatures wouldn't last very long. Not only would they get hypothermia, but the water in their bodies would start to freeze. Some animals and plants, however, use antifreeze proteins to keep ice at bay.
Prepared Foods February 2008 Sharon Book	Article: Protein Ingredients for Health and Texture A variety of soy, dairy and egg proteins are available for the food formulator to obtain the desired texture in a food or beverage.
Chemistry World October 2, 2012 Fiona McKenzie	Protein sorting within cells US scientists have used magnetic nanoparticles with specific ligands to latch on to and visualize specific proteins in living cells.
Chemistry World December 9, 2013 James Urquhart	Drug fix for misfolded proteins promises hope for incurable diseases Researchers have been looking into pharmacological chaperones or pharmacoperones. They might treat diseases brought about by genetic mutations that cause otherwise functional proteins to become misfolded or misrouted.
Bio-IT World June 12, 2002 Karen Hopkin	Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease.
Chemistry World March 14, 2012 Helen Bache	Diabetes reduces antioxidant benefits Scientists in China have discovered that the blood plasma proteins of type II diabetes patients reduce the beneficial effects of dietary polyphenols.
Chemistry World July 6, 2007 Michael Gross	Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail.
Chemistry World January 19, 2010 Simon Hadlington	New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions.
Chemistry World June 2009 Michael Gross	Bubble-wrapped frogs Tropical frogs create remarkable protein foams to protect their spawn. Exploration of the underlying chemistry has only just begun
HHMI Bulletin Feb 2012	An Intentional Life Scientists have identified a number of genes associated with familial forms of ALS, and Arthur Horwich has homed in on one of them.
Bio-IT World May 19, 2004	Special Delivery TAT tagging has aroused keen interest in biotech.
Chemistry World October 24, 2008 Hayley Birch	Proteins swap partners UK researchers have discovered that proteins which use metal cofactors can be surprisingly promiscuous metal binders, happily taking up the 'wrong' metal.
Chemistry World February 3, 2010 Simon Hadlington	New 'hook' for reversibly binding molecules to proteins UK chemists have found a simple new 'hook' that allows molecules to be attached to proteins and later removed, something that is currently difficult to achieve.