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Bio-IT World October 10, 2003 Jeffrey Skolnick |
Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways. |
Chemistry World October 27, 2014 Tim Wogan |
Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability. |
Bio-IT World June 12, 2002 Mark D. Uehling |
Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts? |
Wired July 2001 Oliver Morton |
Gene Machine IBM took a dare: Build a supercomputer that predicts the invisible process of protein folding. Spend $100 million, increase processing speed 100-fold, and revolutionize the field. Then convince the biologists it matters... |
Wired John Bohannon |
Gamers Unravel the Secret Life of Protein A look at the protein chemistry world's biennial World Series, a competition to see who can predict the shape a protein will fold into, knowing nothing more than the sequence of its constituent parts. |
Chemistry World April 29, 2013 Caryl Richards |
Protein origami sets scene for designer structures A world first in the art of protein origami has been attained with a novel method of folding a polypeptide chain into a three-dimensional tetrahedron. |
HHMI Bulletin February 2011 Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
Chemistry World November 13, 2014 Katrina Kramer |
Persuading proteins to form porous polyhedra Researchers in the US have designed a hollow cube out of naturally occurring proteins, something that was previously only possible with DNA. |
Bio-IT World December 10, 2002 Kevin Davies |
Do Try This @ Home In the most impressive sign of distributed computing's awesome potential in biology thus far -- at least in peer-review literature -- researchers have simulated the folding of a mini-protein on a microsecond timescale. |
Industrial Physicist Jennifer Ouellette |
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems |
Chemistry World October 27, 2006 Richard Van Noorden |
Synthetic Origami Folds Like Natural Enzymes Researchers have synthesised a large organic molecule that folds up like a small protein, though its backbone is entirely non-biological. The achievement is a step along the path to producing truly synthetic enzymes in the laboratory. |
Bio-IT World November 2006 John Russell |
On the CASP of a DREAM A meeting to evaluate the results of the CASP (Critical Assessment of Techniques for Protein Structure Prediction) 7 predictions is scheduled for this month. |
Chemistry World November 2006 Philip Ball |
Opinion: The Crucible Here are some of the latest instalments in the ongoing story of how protein misfolding causes neurodegenerative diseases -- a story that is not solely about developing clinical treatments or preventative medicines, but which goes to the heart of proteins' role as the stuff of life. |
Chemistry World June 1, 2012 Simon Hadlington |
Protein architecture with atomic precision Researchers have made a key breakthrough in designing and building geometrically defined nanostructures from proteins with unprecedented accuracy. |
HHMI Bulletin Feb 2012 |
An Intentional Life Scientists have identified a number of genes associated with familial forms of ALS, and Arthur Horwich has homed in on one of them. |
HHMI Bulletin May 2010 Richard Saltus |
A Silver Lining Sure, some prions can cause diseases, but others are turning out to be beneficial. |
Chemistry World December 21, 2006 Henry Nicholls |
Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper. |
Chemistry World February 3, 2013 Andy Extance |
Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores. |
HHMI Bulletin Winter 2013 Nicole Kresge |
A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure. |
Chemistry World April 2009 Philip Ball |
Column: The crucible Unwinding protein fibrils could give a glimpse of how peptides survived on early Earth |
Chemistry World November 27, 2013 Jennifer Newton |
A cytochrome from scratch Artificial proteins could be closer to participating in natural biochemical pathways after researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome. |
Wired April 2001 David Ewing Duncan |
The Protein Hunters Step One: Crack the genome. Step Two: Unlock the molecular structure of amino acids. Step Three: Get ready for the robo-fast, custom-drug future... |
Chemistry World February 13, 2014 Philip Ball |
Ice core to antifreeze protein's inner workings The antifreeze protein that protects the winter flounder from sub-zero temperatures has been found to have an odd structure. |
Chemistry World September 29, 2010 Hayley Birch |
Protein folding: knotted or not A new study may help scientists unravel the complex problem of protein folding. The study suggests knotted proteins, which present a particular challenge to folding experts, could be untied with a couple of well-targeted tugs. |
HHMI Bulletin Fall 2012 Ingfei Chen |
Same But Not Equal A code within the genetic code explains why identical proteins are produced at varying speeds. |
Chemistry World June 25, 2013 Michael Gross |
A foaming protein from the horse's mouth Researchers in the UK have solved the structure of this protein, yielding tantalizing hints to a novel kind of surface activity and to evolutionary connections to other examples. |
Chemistry World August 26, 2008 Fred Campbell |
High-throughput protein microarrays on the way A new method to rapidly generate protein microarrays has been developed by UK researchers at the University of Manchester. |
HHMI Bulletin Spring 2013 Nicole Kresge |
A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology. |
HHMI Bulletin Fall 2012 Halleh B. Balch |
Like a Chinese Finger Trap In neurodegenerative diseases like Alzheimer's, the needle-like fibers that accumulate in the brain are not the real damage-doers. The culprits are intermediate protein structures, called small amyloid oligomers, made of a few proteins that misfold and aggregate. |
Chemistry World October 8, 2008 Sarah Houlton |
Artificial protein chemistry licensed to industry UK researchers are licensing to industry their method of making artificial proteins by chemically modifying individual amino acid structures. |
Bio-IT World April 15, 2003 Malorye Branca |
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? |
Chemistry World July 6, 2007 Michael Gross |
Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail. |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. |
Prepared Foods February 2008 Sharon Book |
Article: Protein Ingredients for Health and Texture A variety of soy, dairy and egg proteins are available for the food formulator to obtain the desired texture in a food or beverage. |
Chemistry World June 2009 Michael Gross |
Bubble-wrapped frogs Tropical frogs create remarkable protein foams to protect their spawn. Exploration of the underlying chemistry has only just begun |
HHMI Bulletin February 2012 Sarah C. P. Williams |
Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors. |
Chemistry World February 7, 2007 Bea Perks |
Protein's Non-Natural Alternative Beta peptides are of interest because of what they can tell researchers about protein folding in general. Now, chemical biologists have built what they say is a 'remarkably protein like' structure from beta peptides. |
Bio-IT World November 2006 |
Briefs Supercomputer vs Superbug... Clinphone Buys; Phase Forward Thrives... Illumina Wins Amgen Deal... CASP's Protein Prodigals... |
Bio-IT World August 15, 2005 Robert M. Frederickson |
What's 'Post' About Postgenomic? Bioinformatics tools can help organize and study genomic sequences that were discovered in the '90s. The tools help with tasks like analyzing gene expression, predicting protein structure and function, and establishing networks of interacting protein in cells. |
Bio-IT World June 2006 Kevin Davies |
David Shaw: No Hedging on Future of Computer Simulations The computational scientist who founded the world's largest alternative investment firm says he is two years away from building a new breed of computer that could be a major breakthrough in structural biology -- simulating the process of protein folding and protein-drug interactions. |
Chemistry World March 23, 2012 Michael Gross |
Molecular chaperones caught on film Researchers have combined thousands of snapshots of the barrel-shaped protein GroEL to create a series of films that follow its movement and binding events. |
Chemistry World March 16, 2014 Simon Hadlington |
Short peptides self-assemble into a catalyst Researchers in the US have created catalysts from peptide chains that are only seven amino acids long. |
Science News October 14, 2006 Ivars Peterson |
Knots in Proteins Knotted proteins are rare, but more than just random occurrences. The secret of spontaneous knotting lies in the mathematics of self-avoiding random walks. |
Chemistry World January 12, 2015 Emma Stoye |
Protein mutant libraries to probe diseases' genetic link quickly and cheaply Researchers in the US have developed a faster and less costly way to investigate the effects of genetic mutations on proteins, which should offer new insights into hereditary diseases. |
Industrial Physicist Aug/Sep 2003 Ineke Malsch |
Protein research calls for advanced instruments The science of protein interactions is becoming a major tool in biomedical and drug development research. Carrying out and advancing such studies more efficiently and effectively, however, will require new, cutting-edge instrumentation. |
Technology Research News January 1, 2003 Eric Smalley |
Altered protein orders metal bits Researchers from NASA, the SETI Institute and Argonne National Laboratory have genetically modified a bacteria that lives in geothermal hot springs in order to make a microscopic scaffolding that produces a high-tech material. |
Reactive Reports Issue 51 David Bradley |
Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique. |
Technology Research News March 24, 2004 |
DNA has nano building in hand Researchers from Ludwig Maximilians University in Germany have built a simple molecular machine from DNA that can bind to and release single molecules of a specific type of protein. |
Chemistry World September 14, 2011 Laura Howes |
Aspirin Still Has Some Secrets Left to Give up The overlooked stereoelectric effect in aspirin makes the molecule less polar, which may improve the drug's bioavailability. |
Chemistry World July 31, 2012 David Bradley |
Hydrogels can release drugs one at a time A hydrogel that can be programmed to release different protein drugs one after the other rather than all at once could simplify the delivery of complex therapeutic regimens for various diseases. |