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Chemistry World
June 14, 2009
Hayley Birch |
New technique probes Alzheimer's aggregates US and UK researchers have used a new technique to identify what they think could be the primary toxic species in the development of Alzheimer's disease   |
Chemistry World
September 12, 2014
Hayley Simon |
Coated nanoparticles show Alzheimer's promise Nanoparticles coated in an amino acid polymer have been found to prevent the formation of amyloid fibrils -- incorrectly folded protein fibers associated with the development of neurodegenerative diseases. |
Chemistry World
November 2006
Philip Ball |
Opinion: The Crucible Here are some of the latest instalments in the ongoing story of how protein misfolding causes neurodegenerative diseases -- a story that is not solely about developing clinical treatments or preventative medicines, but which goes to the heart of proteins' role as the stuff of life. |
Chemistry World
June 17, 2012
Jon Evans |
Anti-social amino acids gang up Previously thought to be purely the preserve of proteins and peptides, scientists have discovered that the amino acid phenylalanine can form the toxic amyloid fibrils that are a hallmark of diseases such as Alzheimer's and Parkinson's. |
Chemistry World
April 30, 2007
Victoria Gill |
Amyloid Protein Seen to Zip Together Amyloid proteins' long, complicated structure makes them tricky to study, but U.S. researchers have found that they share a common feature that could provide a drug target for an array of incurable conditions. |
Chemistry World
March 16, 2014
Simon Hadlington |
Short peptides self-assemble into a catalyst Researchers in the US have created catalysts from peptide chains that are only seven amino acids long. |
Chemistry World
September 21, 2006
Michael Gross |
Alzheimer's Alphabet Alzheimer's researchers are now closer to understanding the natural function of one of the two enzymes that cut A out of APP, and have recreated the process by which fibril formation begins in vivo. |
Chemistry World
April 2009
Philip Ball |
Column: The crucible Unwinding protein fibrils could give a glimpse of how peptides survived on early Earth |
Chemistry World
July 6, 2012 |
Protein power Tom Muir, professor of chemistry and molecular biology, Princeton University, US, is an expert in protein engineering and its application to studying cellular signalling networks. |
Chemistry World
November 15, 2010
Manisha Lalloo |
pH prompts protein structure US researchers studying the naturally-occurring amyloid protein Pmel17 have discovered that pH plays an important role in its structure, helping the body control its aggregation. |
Chemistry World
September 13, 2012
Andy Merritt |
Chemical biology comes of age Historically strongest in the US, chemical biology has become increasingly important worldwide, but for many years researchers at the chemistry -- biology interface have struggled to establish their discipline |
HHMI Bulletin
Fall 2012
Halleh B. Balch |
Like a Chinese Finger Trap In neurodegenerative diseases like Alzheimer's, the needle-like fibers that accumulate in the brain are not the real damage-doers. The culprits are intermediate protein structures, called small amyloid oligomers, made of a few proteins that misfold and aggregate. |
Chemistry World
July 22, 2009
Phil Taylor |
New drug turns Alzheimer's theory on its head Researchers have been left puzzled by data showing that the antihistamine dimebolin, a drug with promising activity in improving Alzheimer's symptoms, actually seems to increase levels of the toxic protein beta amyloid. |
Chemistry World
January 2008
Gurney & Adams |
Comment: How Good is UK Chemistry? Using bibliometrics as the key measure, the author compares the publication output of different countries. |
HHMI Bulletin
Nov 2011
Sarah C.P. Williams. |
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. |
Bio-IT World
September 2006
Nat Goodman |
Getting a Handle on Systems Biology Systems biology is squarely an experimental field that eats, drinks, and breathes data. To do systems biology, you need an experimental system that is amenable to large-scale experimentation. |
Chemistry World
July 30, 2008
Sarah Houlton |
A metal trap to stop Alzheimer's Trapping metals could prove a key to curing Alzheimer's disease, according to the promising results of early clinical trials on a compound called PBT2. |
