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HHMI Bulletin Winter 2013 Nicole Kresge	A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure.
HHMI Bulletin Spring 2013 Nicole Kresge	A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology.
Chemistry World October 31, 2010 Michael Gross	Kiss of death for cancer cells Scientists have deciphered the surprising structure of the perforin pore, which delivers the 'kiss of death' to virus-infected cells and cancer cells in the body.
Chemistry World November 2009	Biology's Nobel molecule factory Three scientists who revealed the structure and workings of the ribosome have shared the 2009 Nobel prize in chemistry.
Chemistry World October 25, 2007	Elusive Drug Target Finally Seen Scientists have captured an atomic-scale picture of a receptor protein from a family that is the target of thousands of drugs.
Chemistry World December 6, 2006 Jessica Ebert	Structure of Key Influenza A Protein Revealed The crystal structure of a molecule important for the replication of the influenza A virus has been solved. Now that scientists know what the protein looks like they can design drugs that block its action and prevent viral spread through the body.
Chemistry World October 7, 2009 Sarah Houlton	Chemistry of life wins Nobel This year's chemistry Nobel prize has been awarded to scientists working on the chemistry of life - the translation of DNA information into proteins by the ribosome.
Chemistry World August 8, 2012	Protein Coat for Gene Therapy Kenneth Woycechowsky's group at the University of Utah has modified a non-viral protein so that it will carry RNA.
Chemistry World November 25, 2009 Simon Hadlington	Virus shells traps multiple proteins Scientists in The Netherlands have devised a way to pack large numbers of proteins into the empty shell of a virus.
Chemistry World November 13, 2014 Katrina Kramer	Persuading proteins to form porous polyhedra Researchers in the US have designed a hollow cube out of naturally occurring proteins, something that was previously only possible with DNA.
Chemistry World May 12, 2008 Simon Hadlington	'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria.
Chemistry World February 3, 2010 Simon Hadlington	New 'hook' for reversibly binding molecules to proteins UK chemists have found a simple new 'hook' that allows molecules to be attached to proteins and later removed, something that is currently difficult to achieve.
Chemistry World September 24, 2007 Simon Hadlington	Viral Nanoreactor Captures Single Molecules Researchers in the Netherlands have created a biochemical nanoreactor by cracking open a virus, removing its contents then reassembling the virus's protein coat around a single molecule of enzyme.
Chemistry World August 26, 2014 Andy Extance	No-frills coats set a trend for designer viruses Dutch scientists have built a simple model of viruses' protective coats in an attempt to create viral mimics that could fight diseases, as opposed to causing them.
Chemistry World March 6, 2007 Michael Gross	Nature's Supramolecular Chemistry Researchers studying a bacterial molybdenum-storage protein have teamed up with inorganic chemists to resolve the structure of the storage protein's central cavity.
Chemistry World October 19, 2007 Richard Van Noorden	Building Tomorrow's Nanofactory UK scientists have been granted 2.5 million pounds to invent a nanomachine that can build materials molecule by molecule. Such a robot doesn't -- and may never -- exist, though it has been imagined for over half a century.
Chemistry World March 23, 2012 Michael Gross	Molecular chaperones caught on film Researchers have combined thousands of snapshots of the barrel-shaped protein GroEL to create a series of films that follow its movement and binding events.
Reactive Reports Issue 51 David Bradley	Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique.
Chemistry World April 30, 2007 Victoria Gill	Amyloid Protein Seen to Zip Together Amyloid proteins' long, complicated structure makes them tricky to study, but U.S. researchers have found that they share a common feature that could provide a drug target for an array of incurable conditions.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World June 14, 2007 James Mitchell Crow	Young-Ish Giants Party On Chemist Fraser Stoddart celebrated his 65th birthday in scholarly style last week, with a group of chemistry's rising stars that raised a glass - and a slide or two - in his honor.
Chemistry World October 21, 2010	Studies Probe Key Flu Protein New details about the structure of an influenza protein that is a key drug target have been revealed in separate studies by groups in the US. The two studies provide insights into the workings of the protein machinery that the virus needs to infect cells.
HHMI Bulletin Winter 2013 Amber Dance	A Trick of Light When miniSOG protein takes in blue light, it converts ordinary oxygen into a short-lived, excited state called singlet oxygen, which reacts with and changes the molecules around it. The singlet oxygen destroys the mitochondria's delicate machinery.
Chemistry World October 8, 2008 Sarah Houlton	Artificial protein chemistry licensed to industry UK researchers are licensing to industry their method of making artificial proteins by chemically modifying individual amino acid structures.
Bio-IT World July 15, 2003 Julia Boguslavsky	'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry.
Chemistry World October 16, 2006 Michael Gross	Brief Encounter Observing fleeting interactions between molecules in solution requires extremely sophisticated methods. NMR spectroscopists have now developed tools that let them watch the transient encounter between two proteins before a well-defined complex is formed.
HHMI Bulletin February 2012 Sarah C. P. Williams	Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors.
Chemistry World June 14, 2011	A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR.
Chemistry World August 2, 2012 Philip Ball	Polymer replacement for the hydration shell The sheath of water molecules, called a hydration shell, that gives protein molecules the flexibility to do their catalytic job can be replaced by polymers, according to Adam Perriman of the University of Bristol and his coworkers.
Bio-IT World October 10, 2003 Jeffrey Skolnick	Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways.
Chemistry World March 8, 2013 David Bradley	The next big thing in mass spectrometry Researchers have used quadrupole time-of-flight native MS to investigate intact capsids from a bacteriophage. While there is theoretically no upper limit on the mass of a particle that might be analyzed, the work is far from trivial in breaking the record.
Chemistry World March 27, 2013 Akshat Rathi	Molecular cages to end crystallization nightmare X-ray crystallography has shaped modern chemistry. It is a powerful tool for molecular structural analysis. But it suffers from one big drawback: it can only analyze materials that form well-defined crystals. This may now be about to change.
Chemistry World February 3, 2013 Andy Extance	Enzyme draws nanopore protein sequencing nearer US scientists at the University of California, Santa Cruz, have made a key step towards nanopore protein sequencing, thanks to an 'unfoldase' enzyme. Mark Akeson's team exploited this enzyme to unravel proteins and pull them through nanopores.
Chemistry World July 6, 2012	Protein power Tom Muir, professor of chemistry and molecular biology, Princeton University, US, is an expert in protein engineering and its application to studying cellular signalling networks.
HHMI Bulletin February 2011 Michele Solis	Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time.
Pharmaceutical Executive November 1, 2006	Thoughtleader: Making Things Stick Ambrx has created the "glue" that allows researchers to attach activity-enhancing molecules to amino acids where they couldn't before.
Chemistry World January 4, 2007 Henry Nicholls	Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell.
Chemistry World June 1, 2012 Simon Hadlington	Protein architecture with atomic precision Researchers have made a key breakthrough in designing and building geometrically defined nanostructures from proteins with unprecedented accuracy.
HHMI Bulletin Winter 2013 Megan Scudellari	Tunneling Out A research team including HHMI investigator Melissa Moore at the University of Massachusetts Medical School has discovered an alternative passageway used by RNA -- protein complexes to exit the nucleus.
HHMI Bulletin May 2010 Richard Saltus	A Silver Lining Sure, some prions can cause diseases, but others are turning out to be beneficial.
Chemistry World June 6, 2010 Philip Ball	Blood-like liquid protein formed A liquid form of the oxygen-binding protein myoglobin retains its biological function even though it seems virtually water-free, researchers have found.
Chemistry World January 19, 2011 Jon Cartwright	Modified protein binders give shortcut to drugs The method, which involves attaching polypeptides to the binders, could help reduce the work required to develop protein binders into safer drugs.
Chemistry World July 23, 2012 Jennifer Newton	Delivering insulin in a skin cream Scientists in Japan have developed a way to administer insulin to patients through the skin.
Chemistry World March 29, 2009 Lewis Brindley	Gene gels pump out proteins Gels made with genes incorporated into the structure could soon make protein production cheaper and easier, according to researchers in the US.
Chemistry World October 8, 2014	Super-resolution light microscopy wins chemistry Nobel The 2014 chemistry Nobel prize has been given to three pioneers of biomedical imaging, whose work has enabled nanoscale features within cells to be captured in exquisite detail.
Chemistry World December 21, 2006 Henry Nicholls	Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper.
Chemistry World July 6, 2007 Michael Gross	Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail.
Chemistry World April 26, 2009 Simon Hadlington	Glowing protein in 'animal photosynthesis' Scientists have discovered that a glowing protein found in some exotic marine animals and used widely as a 'marker' in molecular biology has another remarkable property
HHMI Bulletin February 2011 Sarah C.P. Williams	Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions.
Chemistry World December 19, 2007 Simon Hadlington	Snapshot of Proteins Linked to Autism Researchers in France and the US have caught on camera the gentle embrace between two proteins that sit on either side of the junction between nerve cells. It's this short circuit that has thought to cause some types of autism.