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Chemistry World December 8, 2011 Sarah Farley |
Capturing Compounds in Cages for Chemical Control Scientists from the UK have used a molecular capsule to control the reactivity of an organic compound. |
Chemistry World August 22, 2012 Philip Ball |
The automatic chemist Bartosz Grzybowski of Northwestern University -- who has already established himself as one of our most inventive chemists -- has unveiled a 'chemo-informatic' scheme, Chematica, that can stake a reasonable claim to being paradigm-changing. |
Chemistry World March 2012 |
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Reactive Reports Issue 60 David Bradley |
Mark Leach Interview with the owner of Meta-Synthesis, a company aimed to reveal the inner secrets of chemistry to as wide an audience as possible. |
Chemistry World June 19, 2013 John Hayward |
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide. |
Chemistry World March 19, 2009 Manisha Lalloo |
Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World July 10, 2013 Karl Collins |
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort. |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database. |
Chemistry World February 8, 2006 Jon Evans |
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space. |
Information Today June 17, 2014 |
Wiley Enhances Its Science Solutions Wiley acquired SimBioSys, a scientific software provider of tools used in the drug discovery process. |
Chemistry World August 3, 2007 Simon Hadlington |
Making Light Work of Drug Release UK researchers have borrowed a technique from organic synthetic chemistry to develop a new type of drug-release system that is activated by light. |
Chemistry World August 10, 2007 Richard Van Noorden |
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists. |
Chemistry World March 10, 2006 |
Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates. |
Chemistry World May 13, 2009 James Urquhart |
Insight into RNA origins UK researchers have offered new insight into the origins of RNA and possibly life itself. |
Chemistry World August 2007 Derek Lowe |
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. |
Chemistry World September 26, 2012 Derek Lowe |
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run? |
Chemistry World November 2007 |
Book Reviews A review of books on: good clinical & laboratory practices, green chemistry, environmental chemistry, organic reactions in water, universal asymmetry, and molecular models for fluids. |
Chemistry World July 17, 2014 Andy Extance |
Linguistic statistics enable synthetic prophetics 'Modern computational linguistics is pattern recognition,' explains Bartosz Grzybowski, whose team has integrated the approach into Chematica, a synthetic pathway discovery tool scheduled for a November or December launch. |
Chemistry World December 2007 Richard Van Noorden |
Surfing Web2O The rapid evolution of the world wide web is creating fresh opportunities - and challenges - for chemistry. |
Chemistry World December 3, 2009 Simon Hadlington |
C-H Bond Activation Takes the Relaxing Route Chemists have uncovered a key factor that helps determine the reactivity of a C-H bond to oxidation. |
Chemistry World September 9, 2011 James Mitchell Crow |
High-throughput catalyst screening for the masses Using nothing more than the standard chemistry lab equipment, researchers in the US have successfully turned the discovery of new catalytic reactions into a high-throughput process. |
Chemistry World October 12, 2011 Joanne Thomson |
Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry. |
Reactive Reports Issue 49 |
Star Picks Chemogenesis is an e-book that goes in depth into chemical reactions and reactivity... Check out the Wiki books on chemistry for an open source chemistry textbook... |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. |
Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis. |
Chemistry World April 2007 Derek Lowe |
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? |
Chemistry World November 1, 2007 Richard Van Noorden |
Step Change for Organic Synthesis US chemists discovered how to attack a complex molecule's unreactive carbon-hydrogen bonds, without resorting to wasteful synthetic aids like protecting and directing groups. |
Chemistry World September 12, 2010 Simon Hadlington |
Isotope effect seen on single molecule The isotope effect - where the rate of a reaction is altered depending on the presence of a given isotopic atom in the reactant - is a key tool for elucidating reaction mechanisms |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World January 29, 2008 Richard Van Noorden |
Microsoft Ventures Into Open Access Chemistry Computational chemists have secured funding from computing giant Microsoft to showcase how chemistry can benefit from open access data sharing on the internet. |
Information Today July 2, 2015 |
Thieme Chemistry Updates Synthetic Organic Chemistry Resource Thieme Chemistry rolled out the newest release of its Science of Synthesis 4.1, which is a full-text resource for methods and experimental procedures in synthetic organic chemistry. |
Chemistry World October 5, 2006 Mark Peplow |
Boron Shows Its Negative Side A molecule that hosts a negatively-charged boron atom could prove to be an exciting addition to the chemist's toolbox, according to researchers who have isolated the anion as its lithium salt. |
Chemistry World October 6, 2010 Simon Hadlington |
Trio share Nobel for palladium-catalysed cross-coupling Richard Heck of the University of Delaware in Newark, US, Ei-ichi Negishi of Purdue University, US, and Akira Suzuki of Hokkaido University in Japan, independently developed palladium-catalysed cross-coupling reactions as a way to forge new carbon-carbon bonds with precision |
Chemistry World July 17, 2014 Karl Collins |
Organic chemistry: a mechanistic approach Aimed at undergraduate chemistry students, this relatively succinct text begins with the fundamentals of molecular structure and introduces the concept of molecular orbitals early. |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World May 25, 2007 Richard Van Noorden |
Keeping it Green Some chemistry enthusiastically labeled as green may be nothing of the kind, warn researchers who worry that mediocre -- if well-meaning -- science is damaging their subject. |
Chemistry World September 15, 2011 David Bradley |
Sound Approach to Unclicking Click Chemistry Ultrasound can be used to physically release a triazole from a polymer-companies. |
Chemistry World October 28, 2013 Edward Anderson |
More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis. |
Chemistry World March 21, 2007 Alison Stoddart |
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. |
Chemistry World September 2008 Derek Lowe |
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' |
Chemistry World June 12, 2013 Kirsty Muirhead |
An end to chasing molecules that were never there? Ariel Sarotti from the Rosario National University, Argentina, has developed a new, computationally inexpensive method combining calculated and experimental 13C NMR data to flag up incorrect structures. |
Reactive Reports September 2007 David Bradley |
Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps. |
Chemistry World February 27, 2012 Phillip Broadwith |
Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde. |
Chemistry World March 20, 2008 James Mitchell Crow |
Surfactants Help Reactions Work in Water Scientists have discovered a surfactant that allows the catalytic organic reactions commonly used to assemble organic structures such as drug molecules to be run in water. |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan. |
Chemistry World July 14, 2009 Phillip Broadwith |
Multicomponent reactions step up a gear Dutch chemists have taken multicomponent reactions to the next level, combining a total of eight different starting materials in a single flask, bringing together three different multicomponent reactions and making nine new bonds in a single step. |
Chemistry World February 11, 2008 Lewis Brindley |
Oxidation Goes Green A new 'green' strategy for making useful nitrogen-based chemicals has been announced by chemists in the UK. |