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Chemistry World August 2007 Derek Lowe	Opinion: In the Pipeline Process chemists just don't get the credit they deserve.
Chemistry World October 2009	Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions
Chemistry World August 2008	Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World June 24, 2010 Phillip Broadwith	Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists.
Chemistry World October 15, 2012 Melissae Fellet	Synthesis by mass spectrometry Chemists have used mass spectrometry, commonly used to analyze molecules, to synthesize them on the microscale.
Chemistry World July 14, 2009 Phillip Broadwith	Multicomponent reactions step up a gear Dutch chemists have taken multicomponent reactions to the next level, combining a total of eight different starting materials in a single flask, bringing together three different multicomponent reactions and making nine new bonds in a single step.
Chemistry World March 2012	Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug
Chemistry World September 20, 2007 Lewis Brindley	New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.
Chemistry World June 1, 2012 Derek Lowe	Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that.
Chemistry World July 30, 2015 Derek Lowe	A precision instrument? How much do medicinal chemists and their biology colleagues really trust each other's data? In the end, they have to, because drug discovery is a team sport.
Chemistry World September 28, 2015 Karl Collins	A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research.
Chemistry World September 9, 2011 James Mitchell Crow	High-throughput catalyst screening for the masses Using nothing more than the standard chemistry lab equipment, researchers in the US have successfully turned the discovery of new catalytic reactions into a high-throughput process.
Chemistry World September 26, 2012 Derek Lowe	Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run?
Chemistry World October 29, 2009 Phillip Broadwith	Two metals are better than one UK chemists have developed reagents that can metallate ethers and ethene at room temperature without them disintegrating.
Chemistry World April 2007 Derek Lowe	Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?
Chemistry World July 10, 2013 Karl Collins	An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort.
Chemistry World February 2008 Dylan Stiles	Column: Bench Monkey Cast a skeptical eye over new ideas in chemistry.
Chemistry World November 2010	Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize.
Chemistry World January 13, 2011 Sarah Corcoran	Unclogging the problems of flow chemistry US scientists have found a way to stop solid byproducts clogging channels in continuous flow reactors, a problem that has hampered their progress for use in manufacturing pharmaceuticals.
Chemistry World March 8, 2009 Nina Notman	Polymer Crossroads Act as Tiny Reactors Scientists in the US have taken inspiration from a Dutch painter to create ultrasmall chemical reactors at the junctions of overlapping polymer nanofibres
Chemistry World June 18, 2009 Lewis Brindley	Chemical speed-dating even faster Researchers in the US have adapted a DNA amplification technique to develop a simpler way to rapidly screen chemical reactions.
Chemistry World November 28, 2013	Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.
Chemistry World April 25, 2014 Derek Lowe	Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.
Chemistry World October 12, 2011 Joanne Thomson	Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry.
Chemistry World February 21, 2007 Tom Westgate	Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.
Chemistry World February 20, 2012 James Urquhart	Unusual kinetics of catalyst revealed US researchers have elucidated the unusual reaction kinetics of C-H activation by the palladium(II) catalyst (Pd(OAc) 2).
Chemistry World October 3, 2013 Laura Howes	Twisting molecules for faster reactions Physical chemists in Germany and Switzerland have combined two different techniques to investigate the reactivities of different conformers -- and found one reaction that went 50% faster for one conformer over the other.
Chemistry World March 20, 2008 James Mitchell Crow	Surfactants Help Reactions Work in Water Scientists have discovered a surfactant that allows the catalytic organic reactions commonly used to assemble organic structures such as drug molecules to be run in water.
Chemistry World February 20, 2008 Simon Hadlington	Chemists Tame Acetaldehyde German chemists have prevented acetaldehyde from running amok during the Mannich reaction, opening up new avenues in drug discovery.
Chemistry World September 2008 Derek Lowe	Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful'
Chemistry World November 3, 2008 Simon Hadlington	Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?
Chemistry World December 5, 2012 Phillip Broadwith	Chemical reactions in hot water Chinese and Japanese chemists have highlighted hot water's ability to promote unexpected reactions without any other reagents or catalysts. The work should expand our understanding of how to harness the physicochemical properties of water to potentially replace more complex reagents and catalysts.
Chemistry World January 19, 2010 Simon Hadlington	New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions.
Chemistry World May 31, 2009 Nina Notman	The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used.
Chemistry World March 21, 2007 Alison Stoddart	Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products.
Chemistry World April 10, 2008 Mark Peplow	'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis.
Chemistry World October 2010	Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery
Chemistry World April 12, 2012 Simon Hadlington	Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds.
Chemistry World December 20, 2007 Richard Van Noorden	Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial.
Chemistry World August 30, 2007 James Mitchell Crow	Toxins' Synthesis Secret Cracked US chemists have discovered that using water instead of organic solvents is the key to understanding how algae make toxins called ladder polyethers.
Chemistry World September 12, 2010 Simon Hadlington	Isotope effect seen on single molecule The isotope effect - where the rate of a reaction is altered depending on the presence of a given isotopic atom in the reactant - is a key tool for elucidating reaction mechanisms
Chemistry World June 2008	Column: In the pipeline The author, a medicinal chemist working on preclinical drug discovery, takes a look at the differences between chemists and biologists working on the same team.
Chemistry World January 25, 2007 Richard Van Noorden	Water Surprise for Atmospheric Scientists Lone water molecules can catalyze reactions between atmospheric gases, scientists have confirmed, throwing a wrench in the works of supposedly simple atmospheric chemistry.
Chemistry World August 16, 2009 Tom Bond	Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis.
Chemistry World June 2011	Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most.
Chemistry World February 6, 2011 Laura Howes	Cells as test tubes Chemists have used living cells as test tubes to carry out chemical reactions never before seen within living cells.
Chemistry World May 26, 2015	Catching the runaways I think each cohort of industrial chemists has a runaway industrial reaction that defines their generation.
Chemistry World September 30, 2009 Simon Haddlington	Porous networks trap reactive intermediates Chemists in Japan have shown how it is possible to take sequential x-ray snapshots of chemical reactions taking place within molecular-sized 'reaction chambers', capturing the crystal structures of short-lived reactive intermediates.
Chemistry World January 9, 2014 James Urquhart	Simple route to add nitrogen to drugs US researchers have discovered a simple one-pot, scaleable way to synthesize aziridines -- three-membered rings that are important building blocks for introducing nitrogen into more complex molecules, including medicinal drugs.