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Chemistry World April 2007 Derek Lowe	Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?
Chemistry World March 22, 2012 Ross McLaren	Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule.
Chemistry World September 2008 Derek Lowe	Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful'
Chemistry World June 19, 2013 John Hayward	Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide.
Chemistry World November 28, 2013	Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity.
Chemistry World August 2007 Derek Lowe	Opinion: In the Pipeline Process chemists just don't get the credit they deserve.
Chemistry World March 2012	Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug
Chemistry World July 10, 2013 Karl Collins	An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort.
Chemistry World March 21, 2007 Alison Stoddart	Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products.
Chemistry World May 22, 2015 Jason Woolford	Organic chemistry's complexity conundrum Process chemists in the US have developed a tool to generate a unique index they have termed a molecule's 'current complexity', which also accounts for changes over time due to the impact of new technologies.
Chemistry World November 16, 2012 Yuandi Li	(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines.
Chemistry World September 20, 2007 Lewis Brindley	New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.
Chemistry World April 11, 2014	The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers
Chemistry World January 22, 2014 Eleanor Merritt	Designer esters for complex carbohydrates Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates.
Chemistry World November 2, 2015	Batzelladine B Of all the diverse substances that nature produces, the alkaloids -- small molecules containing basic nitrogen -- have had the greatest impact on human history and health.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World January 18, 2010 Phillip Broadwith	Bending the rules for arynes Two teams of synthetic and computational chemists in the US have developed complementary explanations for the unusual selectivity observed in reactions of indolynes.
Chemistry World August 22, 2012 Philip Ball	The automatic chemist Bartosz Grzybowski of Northwestern University -- who has already established himself as one of our most inventive chemists -- has unveiled a 'chemo-informatic' scheme, Chematica, that can stake a reasonable claim to being paradigm-changing.
Chemistry World November 3, 2008 Simon Hadlington	Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?
Chemistry World May 29, 2013 Paul Docherty	Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.
Chemistry World June 11, 2008 James Mitchell Crow	New Hope for Anticancer Agent The mode of action of a rare natural product with promising cytotoxic activity has been revealed by scientists in the US while a UK group have come up with a particularly efficient chemical synthesis.
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World July 7, 2011 Elinor Richards	Eight Steps to Foil Antibiotic Resistant Bacteria U.S. scientists have synthesised by a new route a key intermediate for the production of synthetic analogues of natural antibiotic tetracyclines that could be used as potential new drugs to combat the growing ranks of antibiotic resistant bacteria.
Chemistry World July 23, 2012 Melissae Fellet	RNA wrapper protects small molecules Step aside benzene rings, there's a new protecting group in town. Dutch researchers have used a strand of RNA to cover portions of a complex small molecule. They then chemically modified a portion of the molecule not covered by the RNA.
Chemistry World March 2011 Paul Docherty	Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction.
Chemistry World August 1, 2013 James Urquhart	Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions.
Chemistry World November 1, 2007 Richard Van Noorden	Step Change for Organic Synthesis US chemists discovered how to attack a complex molecule's unreactive carbon-hydrogen bonds, without resorting to wasteful synthetic aids like protecting and directing groups.
Chemistry World January 7, 2010 Rajendrani Mukhopadhyay	Chemists slam Science paper A paper published in the prestigious journal Science has caused a commotion in the chemistry community, with the synthetic processes discussed in the paper dismissed as nonsense and accusations of a failure in Science's peer review system.
Chemistry World May 2009 Paul Docherty	Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products
Chemistry World November 26, 2013 Paul Docherty	Gone to completion Where is the art of total synthesis headed?
Chemistry World June 2010 Paul Docherty	Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.
Chemistry World May 8, 2014	Mandelalide A The recent synthesis of the proposed structure of mandelalide A is a good example of a well-designed route that seamlessly integrates some cutting-edge chemistry.
Chemistry World November 2007 Dylan Stiles	Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.
Chemistry World November 27, 2008 Lewis Brindley	Bryostatin Synthesis Made Simple US chemists have dramatically shortened the synthesis of byrostatin 16, one of a family of natural products that show promising activity against cancer but can't easily be extracted from nature or made artificially.
Chemistry World August 10, 2007 Richard Van Noorden	Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists.
Chemistry World July 2008 Kevin Rogers	What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril
Chemistry World July 17, 2014 Karl Collins	Organic chemistry: a mechanistic approach Aimed at undergraduate chemistry students, this relatively succinct text begins with the fundamentals of molecular structure and introduces the concept of molecular orbitals early.
Chemistry World August 2011 Paul Docherty	Column: Totally Synthetic Yuanhuapin, a fabulously complex member of the daphnane diterpene orthoester class of natural products, bears an astonishing twelve contiguous stereogenic centres around its seven rings (look closely!).
Chemistry World November 28, 2006 Michael Gross	Synthesis Success After 30 Years Chemists at Harvard have succeeded in synthesizing the antibiotic moenomycin A from scratch. They hope that by providing easier access to this molecule and its variants, they might aid the development of new antibiotics based on its structure.
Chemistry World January 2008 Philip Ball	Column: The Crucible Does chemical space limit a chemists' creativity?
Chemistry World June 2011	Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.
Chemistry World October 12, 2011 Joanne Thomson	Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry.
Chemistry World January 15, 2015 Katrina Kramer	Chemistry's toughest total synthesis challenge put on hold by lack of funds How many chemists does it take to synthesize a molecule? The answer is 20, at least when it comes to maitotoxin, quite possibly the toughest total synthesis challenge around.
Chemistry World May 2012 Paul Docherty	Column: Totally Synthetic Hopeanol and hopeahainol A
Reactive Reports September 2007 David Bradley	Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps.
Information Today July 2, 2015	Thieme Chemistry Updates Synthetic Organic Chemistry Resource Thieme Chemistry rolled out the newest release of its Science of Synthesis 4.1, which is a full-text resource for methods and experimental procedures in synthetic organic chemistry.
Chemistry World July 22, 2015 James Morey	Organic synthesis: state of the art -- 2011--2013 This book would be ideal for those needing to be on top of the literature in synthetic organic chemistry, but who don't have the time to read the ever-increasing body of pertinent articles.
Chemistry World July 1, 2012 Paul Docherty	Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity.
Chemistry World December 3, 2009 Simon Hadlington	C-H Bond Activation Takes the Relaxing Route Chemists have uncovered a key factor that helps determine the reactivity of a C-H bond to oxidation.
Chemistry World October 31, 2012 Paul Docherty	Epicoccin G The class of natural products known as 2,5-diketopiperazines is both broad and synthetically well-trodden. An important sub-class of these targets are found with a sprinkling of sulfur atoms, and seem particularly well-suited to pathogen-bashing.