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Wired July 2001 Oliver Morton |
Gene Machine IBM took a dare: Build a supercomputer that predicts the invisible process of protein folding. Spend $100 million, increase processing speed 100-fold, and revolutionize the field. Then convince the biologists it matters... |
Bio-IT World August 13, 2002 Salvatore Salamone |
Think Blue ... Again: It's in the Genes IBM has big plans for a new petaflop supercomputer -- Blue Gene -- designed primarily for the life sciences. |
Chemistry World July 6, 2007 Michael Gross |
Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail. |
Industrial Physicist Jennifer Ouellette |
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems |
Chemistry World September 29, 2010 Hayley Birch |
Protein folding: knotted or not A new study may help scientists unravel the complex problem of protein folding. The study suggests knotted proteins, which present a particular challenge to folding experts, could be untied with a couple of well-targeted tugs. |
Bio-IT World December 10, 2002 Kevin Davies |
Do Try This @ Home In the most impressive sign of distributed computing's awesome potential in biology thus far -- at least in peer-review literature -- researchers have simulated the folding of a mini-protein on a microsecond timescale. |
HHMI Bulletin Spring 2013 Nicole Kresge |
A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology. |
Chemistry World October 23, 2013 |
Models of success The 2013 Nobel prize in chemistry was awarded to three computational pioneers who combined quantum and classical mechanics. Emma Stoye learns about the latest laureates |
Bio-IT World February 10, 2003 Salvatore Salamone |
Made in Manhattan A talk with the new head of the Computational Biology Center at Memorial Sloan-Kettering. |
Chemistry World October 20, 2013 David Bradley |
Will the sky fall as Dr says no to strong 'bond' Just how strong are non-covalent interactions that control supramolecular complexes and protein structure? Perhaps not as strong as chemists previously thought, according to UK chemists. |
Chemistry World November 23, 2006 Simon Hadlington |
Unfolding Peptide Watched in Real Time Researchers have observed a peptide molecule changing shape in real time. The ultrafast process was monitored using a technique called transient two-dimensional infrared spectroscopy. |
Bio-IT World June 12, 2002 Karen Hopkin |
Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease. |
Bio-IT World February 2007 |
Bio*IT World's Coming Attractions 2007 Bio-IT World Conference & Expo preview -- Meet the Keynotes... Oracle Users... Systems are Go... Candid Camera... A Vital IT Alliance... Next Generation Informatics... etc. |
Chemistry World February 2012 |
Column: The crucible To understand the chemical choreography of the cell, we must acknowledge the bustling biomolecular ballroom in which it takes place, says Philip Ball |
Chemistry World March 16, 2011 |
Inspirational science Seong Keun Kim is head of the Molecular Reaction Dynamics Laboratory at Seoul National University, Korea. He uses spectroscopic, microscopic and computational methods to investigate a wide range of subjects from molecular physics and nanoscience to cell biology. |
Chemistry World July 6, 2012 |
Protein power Tom Muir, professor of chemistry and molecular biology, Princeton University, US, is an expert in protein engineering and its application to studying cellular signalling networks. |
Bio-IT World June 12, 2002 Mark D. Uehling |
Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts? |
Bio-IT World September 2006 Nat Goodman |
Getting a Handle on Systems Biology Systems biology is squarely an experimental field that eats, drinks, and breathes data. To do systems biology, you need an experimental system that is amenable to large-scale experimentation. |
HHMI Bulletin Winter 2013 Nicole Kresge |
A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure. |
Chemistry World March 4, 2015 Philip Ball |
Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all. |
Bio-IT World March 17, 2004 |
Systems Biology: Top-Down or Bottom-Up? Systems biology involves the representation and analysis of an intact biological system. Like many of the technological developments over the past 20 years, such as genomics, proteomics, combinatorial chemistry, and bioinformatics, pharma and medical communities hold high hopes that systems biology will help move molecular research closer to the practice of medicine. |
Chemistry World May 8, 2014 Kai Kohlhoff |
The wisdom of clouds The next generation of scientists must be trained to use cloud resources whenever it makes sense. Then their work will be maintained and used indefinitely, and not end up abandoned in an office corner. |
Bio-IT World August 15, 2005 Robert M. Frederickson |
What's 'Post' About Postgenomic? Bioinformatics tools can help organize and study genomic sequences that were discovered in the '90s. The tools help with tasks like analyzing gene expression, predicting protein structure and function, and establishing networks of interacting protein in cells. |
Industrial Physicist Apr/May 2003 Jennifer Oullette |
Switching from physics to biology Physicists in transition help shape biological theory. |
Bio-IT World December 15, 2003 Zachary Zimmerman |
Learning the Language of Systems Biology Geneticist par excellence David Botstein talks about his philosophy, science, his mission for integrative science, and what he deems a success for systems biology. |
IEEE Spectrum February 2006 Samuel K. Moore |
Ajay Royyuru: Genographer In our genes: How this computational biologist traces the history of human migration through DNA data. |
Chemistry World January 15, 2010 Andy Extance |
Quantum computer hits hydrogen bullseye A basic quantum computer has successfully tackled one of the most challenging tasks facing chemists today - calculating molecular energy from basic scientific principles. |
Industrial Physicist Aug/Sep 2003 Ineke Malsch |
Protein research calls for advanced instruments The science of protein interactions is becoming a major tool in biomedical and drug development research. Carrying out and advancing such studies more efficiently and effectively, however, will require new, cutting-edge instrumentation. |
Food Processing February 2013 Claudia O'Donnell |
Understanding Protein as A Functional Ingredient Ingredient technology advances are providing a growing array of uniquely functional proteins. |
Chemistry World December 21, 2006 Henry Nicholls |
Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper. |
Chemistry World October 27, 2014 Tim Wogan |
Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability. |
Bio-IT World October 10, 2003 Jeffrey Skolnick |
Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways. |
Chemistry World June 1, 2012 Simon Hadlington |
Protein architecture with atomic precision Researchers have made a key breakthrough in designing and building geometrically defined nanostructures from proteins with unprecedented accuracy. |
Bio-IT World June 12, 2002 Beth Schachter |
Informatics Moves to the Head of the Class The race is on to increase the quantity and quality of bio-IT training programs as government and academia bet the need will be great. Will the job market back up that bet? |
Bio-IT World September 11, 2003 Mark D. Uehling |
Fishing Chips The next generation of protein microarrays from the likes of Protometrix and Molecular Staging may threaten the early leads of Biacore and Ciphergen -- and work so well that drug companies won't want them. |
Chemistry World June 14, 2011 |
A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR. |
Chemistry World June 25, 2013 Laura Howes |
Van der Waals forces between atoms measured Lucas Beguin and co-workers at the French National Centre for Scientific Research in Palaiseau, France, however, have developed a new way of measuring these forces. |
Bio-IT World November 19, 2004 Kevin Davies |
The Book on Bioinformatics Research director David Mount talks about his new book "Bioinformatics: Sequence and Genome Analysis," sequence analysis, and teaching bioinformatics |
Chemistry World February 18, 2011 Carol Stanier |
Speed dating for pharmaceuticals A simple analysis of hydrogen bond strengths finds the best crystallisation partners for drugs, say UK scientists. |
HHMI Bulletin February 2011 Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
Reactive Reports Issue 51 David Bradley |
Protein Crystals Trapped Researchers have developed a new technique for crystallizing proteins, which could open up a whole range of materials to this powerful analytical technique. |
InternetNews June 29, 2010 |
Microsoft PR Chief Aims to Settle a Few Scores Microsoft seems to take a healthy dose of abuse from tech pundits and critics in the media, so PR boss Frank Shaw offers a few numbers in defense of his company. |
Chemistry World June 23, 2015 Derek Lowe |
Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example. |
The Motley Fool March 15, 2011 Travis Hoium |
Shaw Group Shares Plunged and Recovered: What You Need to Know Shares of Shaw Group fell as much as 11% this morning, but the bigger news is shares rocketing higher to nearly flat as I am writing. |