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Chemistry World
September 29, 2015
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make? mark for My Articles similar articles
Chemistry World
November 28, 2013
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity. mark for My Articles similar articles
Bio-IT World
April 2007
Vicki Glaser
Software Solutions for Medicinal Chemistry Driven by advances in chemical synthesis, instrumentation, and high-throughput and high-content screening technology, medicinal chemistry's transition from an art to a science is benefiting from a wealth of new software products, spanning both bio- and cheminformatics. mark for My Articles similar articles
Chemistry World
April 25, 2013
Andreas Barth
Chemical bibliometrics Counting compounds instead of publications and citations opens new perspectives for data-based scientific discovery and it can complement and stimulate both experimental and theoretical research. mark for My Articles similar articles
Chemistry World
February 8, 2006
Jon Evans
To Boldly go Where no Chemist Has Gone Before Studying the interactions between different molecular fragments is taking researchers to the uncharted regions of chemical space. mark for My Articles similar articles
Chemistry World
August 22, 2012
Philip Ball
The automatic chemist Bartosz Grzybowski of Northwestern University -- who has already established himself as one of our most inventive chemists -- has unveiled a 'chemo-informatic' scheme, Chematica, that can stake a reasonable claim to being paradigm-changing. mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Reactive Reports
September 2007
David Bradley
Insecticidal Synthesis The efforts of 40 PhD chemistry students and many others have found a way to construct azadirachtin -- a natural insecticide from the neem tree -- in a total synthesis of 64 individual chemical reaction steps. mark for My Articles similar articles
Chemistry World
October 9, 2013
Emma Stoye
Computational chemists take Nobel prize The 2013 Nobel prize in chemistry has been awarded to Martin Karplus of Harvard University, US, Michael Levitt of Stanford University, US, and Arieh Warshel of the University of Southern California, US, for "the development of multi-scale models for complex chemical systems." mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
Chemistry World
July 3, 2014
Tami Spector
Of atoms and aesthetics Molecular aesthetics means many things to a few people. For some it means tangible aspects of compounds; for others yet, the ways that chemists represent molecules. mark for My Articles similar articles
Information Today
September 10, 2001
Robert E. Buntrock
CAS Announces New Features and Improvements at Recent ACS Meeting Although these developments are of primary importance to chemists, I should point out that chemistry is indeed "the central science." Both the science and its unique information-handling challenges are relevant to applications and technologies affecting all of us... mark for My Articles similar articles
Chemistry World
October 2010
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery mark for My Articles similar articles
Bio-IT World
August 18, 2004
Kevin Davies
In Praise of Chemical Diversity How to build better small-molecule libraries. mark for My Articles similar articles
Reactive Reports
November 2005
David Bradley
Peter Murray-Rust An interview with the scientific software developer, originally a crystallographer with a DPhil from Oxford, on how he is now helping to establish novel software and Web technologies for chemists and other scientists underpinned by the concept of open source. mark for My Articles similar articles
Chemistry World
May 31, 2009
Nina Notman
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. mark for My Articles similar articles
Bio-IT World
February 10, 2003
Malorye Branca
Conquering Infinity with Chemical Genetics Harvard superchemist Stuart Schreiber defines the convergence of chemistry and biology. Now the field of chemical genetics is heading toward the clinic. mark for My Articles similar articles
Chemistry World
March 21, 2007
Alison Stoddart
Synthesis Strategy Offers no Protection A radically different approach to constructing complex molecules could help to tap the pharmaceutical potential of natural products. mark for My Articles similar articles
Chemistry World
May 20, 2015
Katrina Kramer
Taking the lead on drug discovery Researchers from the UK have developed a straightforward strategy for making compounds that have the potential to become clinical drugs. mark for My Articles similar articles
Chemistry World
May 29, 2015
Derek Lowe
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. mark for My Articles similar articles
Chemistry World
January 15, 2010
Andy Extance
Quantum computer hits hydrogen bullseye A basic quantum computer has successfully tackled one of the most challenging tasks facing chemists today - calculating molecular energy from basic scientific principles. mark for My Articles similar articles
Chemistry World
March 5, 2015
Emma Stoye
Forgotten synthetic PhD theses set to be given new lease of life A team of researchers have amassed a digital collection of more than 75,000 compounds from PhD theses that might otherwise have mouldered in obscurity. mark for My Articles similar articles
Chemistry World
July 10, 2013
Karl Collins
An 'Aye' for details Today, using methods developed by masters of their trade, the modern greats of total synthesis demonstrate that almost any molecule can be prepared given time and effort. mark for My Articles similar articles
Chemistry World
August 1, 2013
James Urquhart
Total synthesis outshines biotech route to anticancer drug US scientists have developed the first efficient and scalable route for the total synthesis of ingenol -- a plant-derived diterpenoid used to treat precancerous skin legions. mark for My Articles similar articles
Reactive Reports
Issue 64
David Bradley
A Chemist's Thoughts on Computational Power and the Future of 'The Chemical Web' Interview with Steven Bachrach, a chemist with a flare for physics. mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C. P. Williams
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. mark for My Articles similar articles
Chemistry World
March 2011
Column: The crucible Chemistry cannot all be reduced to physics, argues Philip Ball mark for My Articles similar articles
Bio-IT World
September 2006
Kevin Davies
Pfizer's Global Survey of Pharmacological Space The pharma blends knowledge, computational chemistry and research informatics to build a unified database. Gathering all the data in one place offered greater control for indexing and data retrieval and management, enabling Pfizer scientists to perform global mapping. mark for My Articles similar articles
Chemistry World
December 2007
Richard Van Noorden
Surfing Web2O The rapid evolution of the world wide web is creating fresh opportunities - and challenges - for chemistry. mark for My Articles similar articles
Chemistry World
November 3, 2008
Simon Hadlington
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? mark for My Articles similar articles
Chemistry World
July 2008
Mark Peplow
Editorial: There's plenty of room in the middle Today, chemists and biologists are looking at the space between their own disciplines and asking big questions about where science at the interface might lead them. mark for My Articles similar articles
Bio-IT World
April 15, 2003
Mark D. Uehling
Target Elimination Industry and FDA scientists turn to databases, applications software, and laboratory chips to move the safest, most effective molecules into clinical trials. mark for My Articles similar articles
ONLINE
Sep/Oct 2007
Svetla Baykoucheva
A New Era in Chemical Information: PubChem, DiscoveryGate, and Chemistry Central How the emergence of PubChem, DiscoveryGate and Chemistry Central are changing the field of chemical information. mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C.P. Williams.
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. mark for My Articles similar articles
Chemistry World
November 30, 2012
Andy Extance
Chemists cull compounds using 'intuition' Medicinal chemists might be using far fewer parameters to choose candidate fragments for a screening collection than they think they do. Their choices can be mimicked based on just one or two properties, a team led by researchers at Swiss-headquarted pharmaceutical firm Novartis has found. mark for My Articles similar articles
Chemistry World
November 25, 2014
James Urquhart
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. mark for My Articles similar articles
Chemistry World
May 13, 2013
Philip Ball
The name's (quadruple) bond? The nature of C 2 is still imperfectly understood and has recently sparked extensive debate in the chemical literature. The question seems simple: how are the two atoms bonded? mark for My Articles similar articles
Chemistry World
June 2008
Philip Ball
The Crucible By investigating how far a carbon vertex can be bent before it spontaneously flies apart, chemists can gain some understanding of the parameters within which such frameworks must operate. mark for My Articles similar articles
Information Today
December 16, 2010
CAS Introduces SciFinder Enhancements The enhancements will accelerate researchers' workflow and are especially valuable for synthetic chemists and other researchers who are engaged in lab preparations and synthesis planning. mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Chemistry World
December 2007
Alasdair Maclean
Comment: Before the Taps Run Dry Population growth, climate change and pollution are placing huge pressures on the global supply of clean water. Chemists can help. mark for My Articles similar articles
Chemistry World
August 2011
Column: The crucible Philip Ball wonders to what extent molecular structures are metaphorical and philosophical. mark for My Articles similar articles
Chemistry World
June 1, 2012
Derek Lowe
Peace, love and understanding You'd think that the chemists and biologists working in drug discovery would understand each other pretty well by now. You would be wrong about that. mark for My Articles similar articles
Chemistry World
August 13, 2015
Exploiting the data mine Chemists must embrace open data to allow us to collectively get the best out of the masses of new knowledge we unearth, reports Clare Sansom mark for My Articles similar articles
Reactive Reports
December 2006
David Bradley
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database. mark for My Articles similar articles
Chemistry World
January 29, 2015
Santiago Alvarez
What we mean when we talk about bonds The chemical bond is still a matter of lively debate among chemists, even a century after Gilbert Lewis introduced his electron pair bonding concept. mark for My Articles similar articles
Reactive Reports
November 2007
David Bradley
Organic Uranium The first ever uranium methylidyne molecule has been synthesized by US chemists despite the reactivity of the heavy, heavy metal. mark for My Articles similar articles
Chemistry World
August 10, 2007
Richard Van Noorden
Azadirachtin Sees First Total Synthesis A complex natural product has finally succumbed to its first total synthesis after 22 years of attempts by eminent organic chemists. mark for My Articles similar articles