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Chemistry World March 4, 2015 Philip Ball	Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all.
Chemistry World December 12, 2011 Simon Hadlington	Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity.
Chemistry World March 5, 2012 Phillip Broadwith	Magnetic Levitation to Measure Protein Binding A simple device made from two magnets, some polymer beads and a tube of liquid can measure how strongly a protein binds to a ligand.
Chemistry World June 23, 2015 Derek Lowe	Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example.
Chemistry World February 13, 2014 Philip Ball	Ice core to antifreeze protein's inner workings The antifreeze protein that protects the winter flounder from sub-zero temperatures has been found to have an odd structure.
Chemistry World March 14, 2012 Helen Bache	Diabetes reduces antioxidant benefits Scientists in China have discovered that the blood plasma proteins of type II diabetes patients reduce the beneficial effects of dietary polyphenols.
Chemistry World December 2008	Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project.
Chemistry World July 29, 2014 Derek Lowe	The crystal ball that can tell lies X-ray crystallography has long had a sort of halo around it as the 'ground truth' of molecular structure, so many chemists are surprised to learn how rife with error it can be.
Chemistry World November 2, 2009 Simon Hadlington	New way to find drugs' unintended targets Researchers in the US have devised a new way to predict 'off-target' effects for pharmaceutical drugs.
Technology Research News January 14, 2004	Wet biochip preserves proteins Researchers from Kyushu University in Japan have produced a hydrogel material that makes it possible for proteins to survive aboard labs-on-a-chip.
Technology Research News March 23, 2005	Nanowires track molecular activity Researchers from Harvard University have found a way to use transistors made from silicon nanowires to gain information about how small molecules bind to proteins.
Chemistry World November 6, 2009 Phillip Broadwith	Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before.
Chemistry World November 27, 2011 James Mitchell Crow	Artificial enzymes close in on nature A synthetic metalloprotein that approaches the catalytic performance of a natural enzyme, despite its stripped-down structure, has been developed by a team of chemists in the US.
Chemistry World December 2007 Derek Lowe	Column: In the Pipeline The challenge of biologics.
Chemistry World August 6, 2012 Hayley Birch	Sensor a snug fit for glucose A simple approach to making sugar-binding molecules provides a route towards practical glucose-sensing devices.
Industrial Physicist	Biomimetic Nanotechnology Although biomimetic nanotechnology is in its infancy, with no applications yet reaching commercialization, the barriers in some cases lie mainly in scaling up production processes to industrial levels.
Bio-IT World September 11, 2003 Mark D. Uehling	Fishing Chips The next generation of protein microarrays from the likes of Protometrix and Molecular Staging may threaten the early leads of Biacore and Ciphergen -- and work so well that drug companies won't want them.
Chemistry World June 6, 2010 Philip Ball	Blood-like liquid protein formed A liquid form of the oxygen-binding protein myoglobin retains its biological function even though it seems virtually water-free, researchers have found.
Chemistry World September 7, 2008 Simon Hadlington	Coupled proteins to reveal drug hits Researchers in France have successfully attached an 'electrical switch' to a key class of membrane proteins targeted by many drugs.
Chemistry World June 9, 2008 Simon Hadlington	Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes.
Chemistry World June 6, 2014 Philip Ball	Chemistry gets strange at water's surface The attraction of opposite charges may get even stronger near the interface, say colleagues at Rensselaer Polytechnic Institute
Chemistry World October 27, 2014 Tim Wogan	Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability.
Chemistry World August 30, 2011 Laura Howes	G-quadruplexes take the strain in cancer drug search A new single molecule technique can provide greater insight into the interactions between G-quadruplexes and small-molecule ligands.
Chemistry World November 8, 2012 Laura Howes	Self-tying trefoil knot If knotting up molecules is so difficult why not take a tip from nature and get the molecules to do the work for you? This is what Cambridge University researchers found when one of their molecules did indeed tie itself in knots.
Chemistry World November 2006 Philip Ball	Opinion: The Crucible Here are some of the latest instalments in the ongoing story of how protein misfolding causes neurodegenerative diseases -- a story that is not solely about developing clinical treatments or preventative medicines, but which goes to the heart of proteins' role as the stuff of life.
Reactive Reports Issue 49 David Bradley	Hydrophobic Water? Researchers have found evidence to indicate that water molecules don't always want to bond to other water molecules, affecting the uniformity of water forming on metal surfaces.
Chemistry World September 25, 2009 Simon Hadlington	New MRI protein probe Researchers in Japan have invented a new way to detect the presence of proteins in cells and tissues by magnetic resonance imaging.
Technology Research News June 29, 2005	Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined.
Chemistry World October 24, 2008 Hayley Birch	Proteins swap partners UK researchers have discovered that proteins which use metal cofactors can be surprisingly promiscuous metal binders, happily taking up the 'wrong' metal.
Chemistry World September 3, 2008 Hayley Birch	Double emulsions could carry combination therapies US scientists have made nanoscale water-in-oil-in-water emulsions that could have important applications in drug delivery.
Chemistry World April 21, 2006 Philip Ball	In the Blink of an Eye Researchers have found that there's much more to tears than salty water. The liquid film that moistens the eyes has a coating similar to a cell membrane, which keeps debris and bugs out while holding water in, and is structured so that it doesn't get broken up each time we blink.
Chemistry World September 1, 2006 Tom Westgate	Whitesides wins Priestley Medal George Whitesides, professor of chemistry at Harvard University, is to be awarded the 2007 Priestley Medal for a lifetime of achievement in chemistry.
Chemistry World February 12, 2014 Amy Middleton-Gear	Neutralizing heparin without complications Recovering from operations could become easier thanks to a self-assembling multivalent heparin binding agent being developed by scientists in the UK, Italy and Spain.
Food Processing February 2013 Claudia O'Donnell	Understanding Protein as A Functional Ingredient Ingredient technology advances are providing a growing array of uniquely functional proteins.
Chemistry World July 23, 2012 Jennifer Newton	Delivering insulin in a skin cream Scientists in Japan have developed a way to administer insulin to patients through the skin.
Chemistry World October 3, 2013 Emily James	Water's viscosity down to its container - at least at the nanoscale Scientists in the US have discovered that water's viscosity is affected by the material its container is made from.
Chemistry World April 19, 2011 Simon Hadlington	Cell factories package drugs for delivery Scientists in Australia and Germany have used living cells as 'factories' to encapsulate particles such as drugs in biological membranes.
Chemistry World January 16, 2007 Michael Gross	Bioassays Work on Paper New analytical techniques with ever smaller volumes, multiple functionalities, and the ability to run masses of assays in parallel, tend to rely on ever more expensive materials and equipment. Chemists have now bucked this trend by developing a bioassay tool that can be printed on paper.
Chemistry World July 5, 2006 Jon Evans	Perfect Coating Won't Touch Water Imagine a container that can hold liquid without actually touching it. Just such a container could soon become reality following the development by two chemists of a perfectly hydrophobic surface.
Chemistry World January 25, 2012 Jon Evans	Water repellent polymer slows down drug delivery It turns out that superhydrophobic materials are very good at slowly releasing drugs over extended periods of time, from weeks to months.