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Chemistry World May 23, 2013 Rachel Cooper |
The power of multivalency against cholera An international team of scientists has synthesized a cholera inhibitor that matches both the valency and target sugar of the cholera toxin. The molecule is 100,000 times better at trapping the cholera toxin than inhibitors based on the target sugar alone. |
Chemistry World December 3, 2013 Simon Hadlington |
Caged toxin for safer, better bacterial vaccines Researchers in the US have developed a new way of vaccinating against bacterial toxins by caging them in hybrid nanoparticles. |
Chemistry World June 24, 2014 Elisabeth Ratcliffe |
Human protein cleans drinking water Researchers in Japan have shown that they can remove Escherichia coli from drinking water using tiny tubes made of human serum albumin. |
Chemistry World February 12, 2014 Manisha Lalloo |
Synthetic strategy targets 'undruggable' small RNAs Chemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer. |
Chemistry World June 9, 2008 Simon Hadlington |
Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes. |
National Defense November 2010 Eric Beidel |
To Counter Bioterrorism, The Key is Boosting Immunity That's why Texas A&M University researchers are investigating ways to arm Americans against attacks involving toxins, viruses and bacteria. |
Chemistry World December 12, 2011 Simon Hadlington |
Zwitterion approach to stabilizing drug proteins Researchers in the US have discovered a new way to stabilize and protect protein molecules without affecting the protein's biological activity. |
Chemistry World June 23, 2015 Derek Lowe |
Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example. |
Chemistry World May 7, 2014 Emma Stoye |
Bacterium survives unnatural DNA transplant The first organism that can grow and replicate with an unnatural base pair in its DNA -- giving the cell six nucleotides instead of the usual four -- has been created by scientists in the US. |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions. |
The Motley Fool June 29, 2011 Brian Orelli |
4 Immunotherapies to Watch Just don't go all-in. |
Chemistry World September 2, 2007 Simon Hadlington |
Sweet Approach to Tackling Cancer A promising new 'slimline' cancer vaccine that triggers a powerful immune response against excessive sugar molecules has been unveiled by researchers. |
HHMI Bulletin Aug 2011 Richard Saltus |
T-Cell Booster Kits A bioengineer remodels cell surfaces to prod the immune system. |
Chemistry World July 21, 2011 Elinor Richards |
Cell Control to Change Cell Function US scientists can now control the reactions occurring inside cells. |
AskMen.com Jacob Franek |
New Cancer Therapies As cancer research explodes, the availability of new and innovative interventions is expanding almost daily. |
Chemistry World March 4, 2015 Philip Ball |
Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all. |
Chemistry World October 31, 2010 Michael Gross |
Kiss of death for cancer cells Scientists have deciphered the surprising structure of the perforin pore, which delivers the 'kiss of death' to virus-infected cells and cancer cells in the body. |
Chemistry World August 26, 2008 |
Photonic crystal drug detective A new high-throughput screening system based on photonic crystals could quickly and cheaply detect molecules that disrupt binding between proteins and DNA. |
Chemistry World November 25, 2013 Carla Pegoraro |
Steering cells towards biocomputers Bacterial toxins that undergo unique cell interactions have been used to perform logic functions by researchers in Germany. This innovation will help push the limits of synthetic biology. |
Chemistry World June 1, 2009 Phillip Broadwith |
Wider therapeutic possibilities for botulinum toxin Change to a single amino acid in botulinum toxin A causes it to target non-neuronal signalling proteins, potentially widening the product's therapeutic applications |
Chemistry World May 10, 2013 Michael Parkin |
Super Glue for cells Scientists in Canada have made a super-strong cell membrane adhesive and used it to stick red blood cells together. The polymer, based on the phospholipid head group phosphatidyl choline, could be used to secure cells in particular positions for tissue engineering and wound closure. |
Chemistry World February 13, 2014 Philip Ball |
Ice core to antifreeze protein's inner workings The antifreeze protein that protects the winter flounder from sub-zero temperatures has been found to have an odd structure. |
HHMI Bulletin May 2012 Elise Lamar |
Cells on the Move The biochemical signals that set cells on a journey are as diverse as the tissues they move through, but the engine is driven by constant remodeling of a protein network built from a box of cellular Legos. |
Bio-IT World July 15, 2003 Julia Boguslavsky |
'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry. |
Chemistry World March 21, 2014 Richard Massey |
Magnetic field and pH synergy controls therapeutic burst Australian researchers have shown how alternating magnetic fields could be used to localize the release of cancer-fighting drugs to cancer cells, limiting side effects in the rest of the body. |
Chemistry World May 5, 2009 Phillip Broadwith |
Don't FRET over broken polymers Fluorescent proteins could one day help identify microscopic cracks and damage in polymer materials, allowing them to be monitored to prevent failure in load-bearing applications such as in aerospace and biomedical devices. |
Chemistry World August 2, 2012 Philip Ball |
Polymer replacement for the hydration shell The sheath of water molecules, called a hydration shell, that gives protein molecules the flexibility to do their catalytic job can be replaced by polymers, according to Adam Perriman of the University of Bristol and his coworkers. |
Technology Research News June 29, 2005 |
Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined. |
Chemistry World November 27, 2013 Jennifer Newton |
A cytochrome from scratch Artificial proteins could be closer to participating in natural biochemical pathways after researchers show that bacteria will process amino acid sequences entirely unrelated to any natural protein to produce a fully functioning cytochrome. |
Chemistry World October 2, 2012 Fiona McKenzie |
Protein sorting within cells US scientists have used magnetic nanoparticles with specific ligands to latch on to and visualize specific proteins in living cells. |
Chemistry World July 1, 2013 James Urquhart |
Antibiotic research hits a sweet spot UK researchers have found a way to weaken the molecular armour of Escherichia coli to allow the host's immune system to attack and kill the pathogen. |
Chemistry World July 29, 2015 Thadchajini Retneswaran |
Antifreeze polymer protects cells as they thaw Researchers have synthesized a polymer that limits ice crystal growth in frozen red blood cells as they thaw. |
Chemistry World March 5, 2012 Harriet Brewerton |
Picturing Bacteria on Your Phone US scientists have developed a device that, when attached to a mobile phone, can detect small amounts of Escherichia coli in liquid samples. |
Chemistry World July 24, 2012 Rachel Cooper |
Light speeds up new cell growth Scientists from Singapore have combined a photovoltaic polymer with a biocompatible polymer to make a nanofiber-based scaffold that can grow cells for skin regeneration. |
Chemistry World September 30, 2010 Andrew Turley |
Bacteria factories for Taxol precursors Researchers have engineered bacteria to produce precursors of Taxol (paclitaxel), one of the most widely used cancer drugs. |
HHMI Bulletin May 2010 Sarah C.P. Williams |
Lab-Grown Liver New cell culture system solves problem of growing liver cells. |
Chemistry World September 19, 2007 Lewis Brindley |
Cell Destruction by Gel Implosion Scientists in Hong Kong have shown that creating a gel inside bacterial cells can stunt their growth. This research is a step towards developing novel treatments that would target rapidly-reproducing cells such antibiotic-resistant superbugs. |
Chemistry World December 11, 2008 Hayley Birch |
Protein threading paves the way for nanomachines A team of Dutch and Italian researchers has discovered how proteins are threaded through pores in cell membranes. |
Reactive Reports Issue 56 Jeffrey Krise |
A Basic Approach to Chemotherapy Chemists have found a way to attack malignant cells with an anticancer drug, while sparing healthy cells. |
Chemistry World March 17, 2009 Phillip Broadwith |
Electronic 'nose' could shed light on sense of smell Korean researchers have combined human smell receptors with nanotechnology to create a new kind of 'bio-electronic nose' |
Chemistry World February 18, 2008 John Bonner |
Flicking the Acetyl Switch A strain of Escherichia coli that can produce proteins containing an acetylated version of the amino acid lysine could help to reveal how acetylation changes the function of hundreds of proteins inside cells. |
Pharmaceutical Executive July 30, 2007 |
Tomorrow's Drugs A look at the seven top therapies and technologies vying to deliver the next generation of drugs. |
Scientific American July 3, 2006 Jeneen Interlandi |
An Immune Portal Protein may be a key to autoimmune disorders |
Chemistry World June 20, 2013 Jennifer Newton |
Students develop antivenom in high school lab A US high school teacher and nine of his students have made nanoparticles that can neutralize venom from one of the most dangerous snakes in Africa. These nanoparticles could offer a way to make cheaper and more practical antivenoms. |
Chemistry World December 2007 Derek Lowe |
Column: In the Pipeline The challenge of biologics. |
Chemistry World February 24, 2012 Simon Hadlington |
Botox 'bodyguard' gives protein protection Researchers have discovered how one of the most potent toxins known to man can survive in the human stomach and digestive tract. |
Popular Mechanics January 28, 2010 Cassie Rodenberg |
Next-Gen Transplant Techniques Can Stop Organ Rejection About 77 organ transplants are performed each day in the U.S., and more than 101,000 people are on a wait list for body parts such as hearts, skin and veins, according to the Mayo Clinic. |
Chemistry World April 23, 2010 Lewis Brindley |
Ricin antidote on the horizon For the first time, compounds that protect against ricin poisoning have been identified by French researchers. |
Science News January 15, 2005 Christen Brownlee |
The Beef about UTIs E. coli from beef cattle or other livestock may be causing drug-resistant urinary tract infections in women. |
Chemistry World July 28, 2009 Michael Gross |
DNA to direct and switch off chemo Researchers in the US have developed a new approach to cancer chemotherapy using short DNA strands to help target delivery of the drug directly to cancer cells, and 'call it off' should problems arise. |