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Chemistry World January 4, 2007 Henry Nicholls |
Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell. |
Chemistry World July 21, 2011 Elinor Richards |
Cell Control to Change Cell Function US scientists can now control the reactions occurring inside cells. |
HHMI Bulletin Winter 2013 Sarah C.P. Williams |
One Foot in Front of the Other In every type of living cell, materials jet around in a similar variety of manners. The way cellular cargo travels depends on its size, where it's headed, how quickly it must arrive, and how much energy is available. |
HHMI Bulletin May 2012 Elise Lamar |
Cells on the Move The biochemical signals that set cells on a journey are as diverse as the tissues they move through, but the engine is driven by constant remodeling of a protein network built from a box of cellular Legos. |
HHMI Bulletin Nov 2011 Sarah C. P. Williams |
Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems. |
HHMI Bulletin Spring 2013 Nicole Kresge |
A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology. |
Chemistry World October 9, 2011 Simon Hadlington |
New probe throws light on cellular lipids Scientists in the US have developed a new sensor that can track and measure lipids in living cells. |
Chemistry World |
Fishing for Chemical Answers to Biological Questions James K. Chen talks about chemical biology, his love for the outdoors and fly fishing. |
Chemistry World November 25, 2013 Carla Pegoraro |
Steering cells towards biocomputers Bacterial toxins that undergo unique cell interactions have been used to perform logic functions by researchers in Germany. This innovation will help push the limits of synthetic biology. |
HHMI Bulletin Feb 2011 |
DNA Curtains How proteins behave in such a crash test gives scientists data about their structural integrity, how they attach to DNA, and how they behave in a cell. |
HHMI Bulletin Winter 2013 Amber Dance |
A Trick of Light When miniSOG protein takes in blue light, it converts ordinary oxygen into a short-lived, excited state called singlet oxygen, which reacts with and changes the molecules around it. The singlet oxygen destroys the mitochondria's delicate machinery. |
IEEE Spectrum August 2006 Schoenbach et al. |
Zap Extreme voltage could be a surprisingly delicate tool in the fight against cancer. The list of effects that scientists have achieved using nanoseconds-long pulses is growing rapidly, though their actual use as a medical treatment is still years away. |
HHMI Bulletin February 2011 Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
HHMI Bulletin Winter 2013 Nicole Kresge |
A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure. |
HHMI Bulletin February 2012 Sarah C. P. Williams |
Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
HHMI Bulletin May 2012 John Roach |
Tiny Breathing Plant Mouths Keiko Torii was drawn from an interest in cancer research to a career in plant biology, but keeps her eyes open for relevance in both areas. |
Bio-IT World July 15, 2003 Julia Boguslavsky |
'Fingerprinting' a Single Cell Single-cell proteomics is finally within reach, thanks to a professor of analytical chemistry. |
Chemistry World December 21, 2006 Henry Nicholls |
Silent SNPs Serve up a Structural Surprise The sequence of amino acids no longer dictates the structure and function of a protein according to a surprising new paper. |
HHMI Bulletin May 2012 Nicole Kresge |
Locating a Genetic Glitch A team of 41 scientists led by HHMI investigator Louis Ptacek has pinpointed the gene responsible for a rare disease that causes sudden, uncontrollable movements. The culprit is a little known protein that may be responsible for communication between neurons. |
Chemistry World April 19, 2011 Simon Hadlington |
Cell factories package drugs for delivery Scientists in Australia and Germany have used living cells as 'factories' to encapsulate particles such as drugs in biological membranes. |
Bio-IT World May 19, 2004 |
Special Delivery TAT tagging has aroused keen interest in biotech. |
HHMI Bulletin February 2012 Sarah C.P. Williams |
The Twists and Turns of Immunity Fred Alt has built a career making sense of the immune system -- specifically, the diverse antibodies that fight off invading molecules, from viruses to cancer cells to pollen. |
Chemistry World October 1, 2008 Hayley Birch |
Chemical Knockout for Chlamydia US scientists have used chemical inhibitors to block proteins that Chlamydia produces as it invades cells. |
Chemistry World July 6, 2012 |
Protein power Tom Muir, professor of chemistry and molecular biology, Princeton University, US, is an expert in protein engineering and its application to studying cellular signalling networks. |
HHMI Bulletin Aug 2011 Janelle Weaver |
Leading a Double Life with CSF Lucky for us, the organs in our bodies come with a self-repair kit. Though regularly bombarded by harmful bacteria, more often than not they manage to heal themselves. How this happens has puzzled scientists, but now there may be some answers. |
HHMI Bulletin Aug 2010 Richard Saltus |
Three-Dimensional Cell Cultures Thinking big but starting small, Sangeeta Bhatia is closing in on her ambitious goal: growing human livers in the lab from scratch. |
Scientific American July 3, 2006 Jeneen Interlandi |
An Immune Portal Protein may be a key to autoimmune disorders |
Chemistry World May 12, 2008 Simon Hadlington |
'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria. |
Wired August 2003 Jennifer Kahn |
The End of Cancer (As we Know it) Diagnosis. Chemotherapy. Radiation. Slow painful death. No more. A new era of cancer treatment is dawning. Meet three scientists who are using the revelations of the Human Genome Project to reshape medicine. |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Releasing the Brakes on Cell Fate Converting one cell type directly into another is a kind of modern-day alchemy, an ultimate goal in biological research. But unlike turning base metals into gold, changing a cell's identity is feasible, new research shows. |
Chemistry World September 7, 2008 Simon Hadlington |
Coupled proteins to reveal drug hits Researchers in France have successfully attached an 'electrical switch' to a key class of membrane proteins targeted by many drugs. |
Chemistry World April 26, 2009 Simon Hadlington |
Glowing protein in 'animal photosynthesis' Scientists have discovered that a glowing protein found in some exotic marine animals and used widely as a 'marker' in molecular biology has another remarkable property |
Chemistry World August 12, 2011 Manisha Lalloo |
Unraveling cell membranes to understand drugs Researchers in Sweden have found a way to create flattened cell membranes, known as supported lipid bilayers, out of real cell structures. |
Chemistry World February 28, 2013 Andy Extance |
Chemical transport defines 'Goldilocks' cell size A US team has suggested molecular movement as an answer to the question of why cells are the size they are. A question that they say 'still awaits an answer from first principles'. |
Bio-IT World June 12, 2002 Mark D. Uehling |
Putting Proteins in Their Place Will a 'periodic table' of proteins help classify the ungainly beasts? |
Chemistry World June 9, 2008 Simon Hadlington |
Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes. |
HHMI Bulletin Winter 2013 Megan Scudellari |
Tunneling Out A research team including HHMI investigator Melissa Moore at the University of Massachusetts Medical School has discovered an alternative passageway used by RNA -- protein complexes to exit the nucleus. |
Chemistry World October 25, 2007 |
Elusive Drug Target Finally Seen Scientists have captured an atomic-scale picture of a receptor protein from a family that is the target of thousands of drugs. |
Chemistry World May 26, 2011 Russell Johnson |
Hunting elusive green fluorescent proteins After a 40 year hunt, scientists have tracked down the genes responsible for fluorescent proteins in Obelia medusa - a type of jellyfish. Knowledge of these genes could lead to new fluorescent protein tags for use in cell biology. |
Chemistry World August 2, 2011 Kate McAlpine |
Hacking into chemical cell phone calls US researchers have made a nanodevice that can eavesdrop on a cell's mutterings, and they say it could be adapted to listen in on conversations between cells. |
HHMI Bulletin Aug 2011 Cassandra Willyard |
A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice. |
Chemistry World September 10, 2008 Simon Hadlington |
Failed anxiety drug could treat cancer Scientists believe they have solved the mystery of how a drug originally developed for treating anxiety can kill cancer cells. |
Chemistry World May 12, 2014 David Bradley |
Elemental discoveries at the cellular level A combination of two high-power analytical techniques -- synchrotron radiation microscopy and atomic force microscopy -- has allowed Italy scientists to map vital elements in a single cancer cell. |
Pharmaceutical Executive October 1, 2008 |
The other half of an HIV mystery is solved When HIV infects a human immune cell, which of the cell's own genes play a role? |
Chemistry World May 5, 2011 Simon Hadlington |
Revolutionary new single-cell labelling method Researchers in the US and Canada have combined mass spectrometry with a technique called flow cytometry to follow dozens of biochemical markers on individual cells simultaneously. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Chemistry World July 28, 2009 Michael Gross |
DNA to direct and switch off chemo Researchers in the US have developed a new approach to cancer chemotherapy using short DNA strands to help target delivery of the drug directly to cancer cells, and 'call it off' should problems arise. |
Chemistry World October 24, 2008 Hayley Birch |
Proteins swap partners UK researchers have discovered that proteins which use metal cofactors can be surprisingly promiscuous metal binders, happily taking up the 'wrong' metal. |
Chemistry World April 27, 2006 |
`Sticky Trees' Glue Molecules to Proteins Researchers have developed a chemical glue that binds molecules to proteins without compromising protein function. The method could be used to modify a wide range of proteins for a variety of purposes, such as in the development of new protein-based therapies. |