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Bio-IT World April 2007 Kevin Davies |
The Human Metabolome Project Motivated by the absence of a metabolomic equivalent of GenBank that could provide information and possibly even samples of metabolites, researchers secured $7.5 million funding from Genome Canada in 2005 for the "Human Metabolome Project." |
Scientific American February 28, 2005 Gunjan Sinha |
The Diet That Fits With the understanding that some diseases such as obesity are metabolic syndromes in which multiple biochemical pathways interact to cause complex symptoms, metabolic testing offers a way to gauge health over a lifetime. |
Chemistry World April 21, 2008 Pete Mitchel |
The hunt for metabolic biomarkers In the largest metabonomics study ever carried out, researchers have discovered strong correlations between individuals' blood pressure and the levels of certain metabolites in their urine. |
Scientific American June 2008 Melinda Wenner |
Jeremy Nicholson's Gut Instincts: Researching Intestinal Bacteria The body and its intestinal flora produce chemicals with hidden health information, Jeremy Nicholson has found. Someday treating disease may mean treating those bacteria. |
Bio-IT World April 15, 2003 Malorye Branca |
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? |
Chemistry World July 2010 Anna Lewcock |
Medicine made to measure Healthcare tailored to suit the genetic makeup of the patient is finally coming to fruition. |
Bio-IT World August 13, 2002 Malorye Branca |
The Proteomics Odyssey Efforts to map the constellation of protein interactions in humans gather momentum as companies vie to provide tools to capitalize on the potential of proteomics. But can proteomics prevail where some feel genomics has failed? |
Industrial Physicist Jennifer Ouellette |
Bioinformatics moves into the mainstream An explosion of data is being tamed with new systems |
Scientific American November 14, 2005 Gunjan Sinha |
Bugs and Drugs Gut bacteria could determine how well medicines work. |
Bio-IT World May 2006 John Russell |
Metabolon's Bet on Biochemistry CEO of biopharma Metabolon is betting on metabolomics to provide a better approach to new drug discovery. |
Chemistry World January 27, 2011 Elinor Richards |
Diet affects cholesterol drug Copper and zinc in the diet could impair the action of statin drugs, compounds prescribed to lower cholesterol, say US scientists. |
Chemistry World March 7, 2011 Russell Johnson |
Breathe out for personalised medicine A method to analyse drug levels in the body could allow people with epilepsy to avoid weeks of blood tests, claim scientists from Switzerland. |
Bio-IT World July 11, 2002 Malorye Branca |
Deep Sequence Diving Like sailors of old, genomic data miners dream of discovering riches and fame. Given the recent improvements in analytics -- and a little more time -- they just might succeed. |
Chemistry World November 15, 2012 Laura Howes |
Imperial launches second phenome centre Imperial College London, UK, is launching a new clinical phenome center at St Mary's Hospital London, to analyze the phenotypes of patient's samples. The phenotype includes all external products of genes and environment, from hair colour to chemical markers of disease states. |
Chemistry World July 2010 Hayley Birch |
Special Report: Health breakthroughs of the decade New discoveries have been made with cancer vaccines, genomics, statin drugs, allosteric modulators, and RNA interference during the last decade. |
Chemistry World August 1, 2012 Patrick Walter |
Phenomenal Olympic science legacy (or is that sustainability?) What do you do with a lab set up solely to catch Olympic drug cheats once the games are over? In the case of the London 2012 games, the answer is to turn it into a state of the art analytical lab. |
Bio-IT World February 2006 John Russell |
Inside BG Medicine Think Intel Inside, but instead of microprocessors, think industrial-strength experimental platforms, focused on all things omic, designed and even run by a third party, but living deep inside biopharmaceutical companies. This is BM Medicine's CEO Pieter Muntendam's strategy. |
Fast Company November 2009 David H. Freedman |
The Gene Bubble: Why We Still Aren't Disease-Free When the human genome was first sequenced nearly a decade ago, the world lit up with talk about how new gene-specific drugs would help us cheat death. Well, the verdict is in: Keep eating those greens. |
Chemistry World September 30, 2010 Andrew Turley |
Bacteria factories for Taxol precursors Researchers have engineered bacteria to produce precursors of Taxol (paclitaxel), one of the most widely used cancer drugs. |
Bio-IT World April 15, 2003 Mark D. Uehling |
Target Elimination Industry and FDA scientists turn to databases, applications software, and laboratory chips to move the safest, most effective molecules into clinical trials. |
Bio-IT World November 12, 2002 Michael Goldman |
A Virtual Pharmacopeia Computational modeling of disease pathways, organs --- even patients --- could transform drug discovery. Does salvation exist in silico? |
Wired April 21, 2008 Rachel Swaby |
Chromosome, Proteome ... Decoding the DNA of '-omes' The genome alone can't explain how our bodies work. We need to decode a lot of other complex biological systems that regulate how we develop. |
Chemistry World April 11, 2007 Victoria Gill |
A Dog's Life A group of dogs that enjoyed long lives on carefully planned diets has provided researchers with a unique life-long metabolic profile. The data reveal the relationship between diet, disease and longevity. |
Bio-IT World November 12, 2002 James Golden |
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success. |
Salon.com May 1, 2000 Arthur Allen |
Listening to DNA The genome project is getting the buzz. But the real breakthroughs may come from labs out of the limelight, like Gene Logic. |
Bio-IT World September 2006 John A. Wass |
Integrating Knowledge The results of new mathematical routines have the potential to save pharmaceuticals millions of dollars in drug development. And yet the flow of successful drugs is dwindling. The problem goes beyond bureaucracy and lies in the complexity of the problem. |
Bio-IT World October 10, 2003 Donna Mendrick |
Microarrays That Make Drugs Safe Using DNA chips to discover potential toxicity in new drug compounds -- a key application of toxicogenomics -- can predict adverse effects before they occur, enabling safer clinical trials. |
Chemistry World September 24, 2013 Jennifer Newton |
Plants and microorganisms are the original synthetic chemists Greg Challis is a professor of chemical biology at the University of Warwick in the UK. Research in the Challis group encompasses the discovery, biosynthesis, bioengineering and mechanism of action of bioactive natural products. |
Bio-IT World January 21, 2005 |
Defining 'Integrative Genomics' Five experts from academia and industry discuss the burgeoning field of integrative genomics. |
Bio-IT World July 14, 2004 Malorye A. Branca |
The Pathways Promise By using the right tools, even a modest genomic data set can generate a good view into a particular biological pathway. Now, a range of new technologies is arising from academia as well as the commercial sector to meet this need. |
Bio-IT World September 2005 Kristen Amuzzini |
A More Efficient Approach to Biostatistical Data Analysis Using an efficient, integrated approach, data from many different sources can easily be acquired, massaged to ensure its integrity, and then combined into single tables that biostatisticians can use to search for patterns regardless of the source of the data. |
Chemistry World November 2, 2015 Charlie Quigg |
Biomarkers identify stroke victims with cognitive problems Scientists in China have pinpointed three metabolites that indicate if a stroke victim has suffered cognitive damage. |
Knowledge@Wharton |
From Skin Creams to Life Insurance to Medical Care, Biosciences Are the New Frontier of Business Opportunity Research in the biological sciences holds the potential for breakthroughs that could transform the world. But scientific advances also can be baffling and more than a little intimidating, especially for business people... |
Bio-IT World Jul/Aug 2006 Eric K. Neumann |
Combining Drug Toxicity Knowledge Nearly half the drugs entering clinical trials will fail because of some form of serious toxicity that was missed in preclinical studies. These failures should not happen at such a late stage in the process. So what can be done? |
Bio-IT World January 13, 2003 John Dodge |
Talent Fuels Drug Pipeline in Swiss Time The functional genomics group has emerged as a critical link in the drug discovery chain at Novartis Pharmaceuticals Corp. While it employs a multidisciplinary approach to drug discovery, the four-year-old group's goals could not be simpler: Find novel drug targets. |
Bio-IT World May 2006 Robert M. Frederickson |
A New (Bio)Spin on NMR Applications Bruker BioSpin recently announced several introductions to improve throughput, sensitivity, and versatility of its systems for nuclear magnetic resonance applications starting with the SampleJet, a robotics system for high-throughput transfers of NMR sample tubes into the NMR spectrometer. |
Bio-IT World February 10, 2003 Salvatore Salamone |
Made in Manhattan A talk with the new head of the Computational Biology Center at Memorial Sloan-Kettering. |
Managed Care August 2004 Thomas Morrow |
10,000 Cells on a Chip Signal Start of New Era of Diagnosis Diseases will soon be defined by biochemical pathways and genetic interactions. Biochips may identify patients likely to respond to therapeutic agents. All of this is a big deal for health plans. |
Bio-IT World December 15, 2003 Zachary Zimmerman |
Learning the Language of Systems Biology Geneticist par excellence David Botstein talks about his philosophy, science, his mission for integrative science, and what he deems a success for systems biology. |
Bio-IT World October 14, 2004 Zachary Zimmerman |
Follow the Pathway to Increased ROI Although this software has been commercially available for only a year, Ingenuity claims nine of the top 10 pharmaceutical companies as customers, including Pfizer, Wyeth, GlaxoSmithKline, and Aventis. |
Wired August 2000 Jennifer Hillner |
Area 22 The inside story of the first fully sequenced chromosome. |
HHMI Bulletin Aug 2010 Sarah C.P. Williams |
Switching Plants' Reproductive Methods The shipments of seeds that farms rely on at the beginning of each growing season could soon be a relic of the past. Scientists have discovered how to coax plants to clone themselves by altering their reproductive methods. |
Bio-IT World May 2006 Kevin Davies |
Interpreting Genes and Genomes From microarrays to sequencing technology, molecular diagnostics to the interactome, this year's Bio-IT World Conference showcased exciting advances in genome technology applications, in which software analysis and data management play critical roles. |
Chemistry World June 14, 2011 |
A New Spin on Protein NMR A new technique will allow researchers to study protein structure in greater detail using NMR. |
BusinessWeek June 13, 2005 John Carey |
The NIH's Roadmap for Research Charting the human genome was just the beginning. Now the focus is creating pathways that will lead to practical applications. |
Bio-IT World July 2005 Robert M. Frederickson |
Amassing Mass Spectrometry Tools Mass spectrometry is a key tool in the effort to identify protein biomarkers of human disease. Manufacturers have met major challenges in adapting this technology to protein discovery, both qualitatively and quantitatively. |
Chemistry World May 17, 2006 Bea Perks |
Biochemists Reveal Hidden Drug Effects Researchers have identified unexpected drug activities by probing biochemical pathways inside living cells. |
Fast Company September 2000 John Ellis |
The Secret of Life The mapping of the human genome, says Craig Venter, will change science, research, medicine, politics, health insurance, and the way biology looks at the last 3 billion years of evolution. And that's just the beginning. |
The Motley Fool December 10, 2004 Rich Duprey |
Scientists Play Chicken An international scientific consortium decodes the chicken genome. This information may be of use to companies such as Tyson, Pilgrim's Pride, Cal-Maine or even Buffalo Wild Wings. |
Chemistry World May 1, 2014 James Urquhart |
Ancient oceans' metals mimicked metabolism Primitive metabolism of sugar phosphates may have started spontaneously in ancient oceans around 4 billion years ago and given rise to life, according to UK researchers. |