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Chemistry World May 5, 2015 James Urquhart |
Ancient RNA enzymes formed from freeze-thaw cycles UK researchers have shown repeated cycles of freezing and thawing could have allowed the first complex RNA enzymes, or ribozymes, to form on early Earth -- a key step for the evolution of life. |
Chemistry World October 18, 2012 Andy Extance |
RNA teams up to beat selfish rivals A team from Portland State University has shown that cooperative ribozymes -- RNA enzymes -- outdo 'selfish' autocatalytic competitors for the same building blocks. |
Chemistry World April 20, 2009 James Urquhart |
New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought. |
Chemistry World April 7, 2011 Laura Howes |
Long chains give new life to RNA world hypothesis The so-called RNA world hypothesis has gained fresh momentum with the synthesis of the longest lab grown RNA strands made using an enzyme that is itself made of RNA, an 'RNAzyme'. |
Chemistry World April 19, 2012 Andy Extance |
Polymers perform non-DNA evolution Scientists have found that six polymer alternatives to DNA can pass on genetic information, and have evolved one type to specifically bind target molecules. |
Chemistry World March 15, 2007 Henry Nicholls |
The Mother of All Enzymes Scientists have uncovered the three-dimensional structure of what might be biology's first enzyme. This sheds light on the chemistry at a key moment in the origin of life, they argue. |
Chemistry World May 20, 2013 Emma Stoye |
RNA world hypothesis strengthened by iron The RNA world hypothesis has gained another boost after research shows that RNA is more catalytically active under conditions similar to those on Earth billions of years ago. |
Chemistry World September 23, 2009 Simon Hadlington |
Direct route to RNA sequences Scientists in the US appear to have cracked a major problem in molecular biology: how to sequence single molecules of RNA directly. |
Chemistry World January 9, 2009 James Urquhart |
Chemists edge closer to recreating early life A test tube based system of chemicals that exhibit life-like qualities such as indefinite self-replication, mutation, and survival of the fittest, has been created by US scientists. |
Chemistry World May 13, 2009 James Urquhart |
Insight into RNA origins UK researchers have offered new insight into the origins of RNA and possibly life itself. |
Chemistry World May 1, 2014 James Urquhart |
Ancient oceans' metals mimicked metabolism Primitive metabolism of sugar phosphates may have started spontaneously in ancient oceans around 4 billion years ago and given rise to life, according to UK researchers. |
Chemistry World August 7, 2011 Phillip Broadwith |
Possible Origin of Chirality in the Rna World Given a tiny push one way or the other, simple racemic precursors can lead to the chiral building blocks of RNA using a combination of chemical and physical factors. |
Chemistry World January 8, 2012 David Bradley |
The TNA world that came before the RNA one Once it was recognised that DNA is key to the molecular self-replication that underpins life, chemists have sought to understand the origins of this double-helical molecule in that primordial age. |
Chemistry World February 27, 2006 Michael Gross |
A DNA Switch for RNA Folding Researchers have equipped a large RNA domain with a DNA switch, which they say can fold or unfold the RNA molecule at will. |
Technology Research News January 12, 2005 |
RNA Tiles Form Nanopatterns Researchers have developed a method of coaxing artificial RNA molecules to self-assemble into specific shapes, much like a jigsaw puzzle automatically assembling. The structures could eventually be used as templates for nanochips, nanocircuits and nanocrystals |
Scientific American March 2009 W. Wayt Gibbs |
Evolution in a Bottle: Synthetic Life Oozes Closer to Reality Self-replicating RNAs advance science another step toward artificial life |
Scientific American October 2008 Heather Wax |
Using Math to Explain How Life on Earth Began How did self-replicating molecules come to dominate the early earth? Using the mathematics of evolutionary dynamics, Martin A. Nowak can explain the change from no life to life |
Chemistry World March 8, 2010 Lewis Brindley |
Molecular midwives helped birth of DNA 'Molecular midwives' - are compounds that played a crucial role in combining small nucleotide fragments into the first genetic polymeric material. |
Chemistry World August 10, 2015 Kira Welter |
Peptide glue may have held first protocell components together Electrostatic interactions induced by short, positively charged, hydrophobic peptides are all it takes to attach RNA to vesicle membranes. |
Technology Research News June 29, 2005 |
Self-assembly: the natural way to make things In biology, there are a few different ways DNA molecules can be replicated and combined. |
Chemistry World September 7, 2009 |
Bolt-on MOF catalysts Chemists in the US have shown that a class of hugely porous materials called metal-organic frameworks (MOFs) can have catalytic functions bolted onto the structure after it has been constructed to produce efficient catalysts that can be easily recovered and cycled many times. |
Chemistry World July 23, 2012 Melissae Fellet |
RNA wrapper protects small molecules Step aside benzene rings, there's a new protecting group in town. Dutch researchers have used a strand of RNA to cover portions of a complex small molecule. They then chemically modified a portion of the molecule not covered by the RNA. |
Chemistry World October 8, 2013 Hayley Birch |
RNA mimic destined for synthetic genome US scientists have taken another step towards the goal of creating self-replicating molecules like those thought to have spawned life on Earth. The researchers made RNA-like polymers capable of copying short sections of genetic code that they suggest could act as genomes in synthetic cells. |
Scientific American June 2005 JR Minkel |
RNA to the Rescue The spectacular discovery that a species of plant can summon up genes its parents have lost highlights biologists' increasing recognition of RNA as a more versatile and important molecule in its own right. |
Chemistry World January 28, 2011 David Barden |
Chips make short work of RNA synthesis Chinese scientists have developed a much easier way to make the short strands of RNA that are an essential tool in understanding what genes do. |
Chemistry World December 20, 2011 Laura Howes |
Cutting edge chemistry in 2011 With the help of an expert panel of journal editors Chemistry World reviews the ground breaking research and important trends in this year's crop of chemical science papers. |
Scientific American November 2007 Ed Regis |
The Forgotten Code Cracker In the 1960s Marshall W. Nirenberg deciphered the genetic code, the combination of the A, T, G and C nucleotides that specify amino acids. So why do people think that Francis Crick did it? |
Chemistry World June 11, 2009 James Urquhart |
Enzyme-free assembly of DNA-like molecules US scientists have developed a simple peptide nucleic acid system that self-assembles and adapts to new instructions without enzymes. |
Chemistry World November 2007 Philip Ball |
Column: The Crucible It is inevitable that the origins of life on Earth will be forever shrouded in mystery. |
Chemistry World March 14, 2012 James Urquhart |
Catalysis at the flick of a switch German researchers have created a molecular nanoswitch that can be reversibly and repeatedly turned on and off to control a chemical reaction. |
Chemistry World October 2, 2006 Bea Perks |
RNAi Pioneers Win Nobel Prize for Medicine Molecular biologists Andrew Fire and Craig Mello have been awarded this year's Nobel prize in physiology or medicine for their discovery of RNA interference. |
Chemistry World February 1, 2008 Lewis Brindley |
Genetic Code Read Directly From RNA Scientists have directly read the genetic code from a single strand of RNA for the first time, using a combination of powerful microscopes and laser spectroscopy techniques. |
Chemistry World August 2, 2011 Phillip Broadwith |
Protein synthesis hijacked to turn out cyclic peptides Japanese researchers have developed a way of reprogramming the genetic code and using bacteria to make and screen huge libraries of cyclic peptides using unnatural amino acids. |
Chemistry World February 12, 2014 Manisha Lalloo |
Synthetic strategy targets 'undruggable' small RNAs Chemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer. |
Chemistry World October 1, 2010 Hayley Birch |
On-off catalyst mimics enzyme function US and Japanese researchers have created an enzyme-like catalyst whose activity can be switched on or off using small molecules. |
HHMI Bulletin February 2012 Sarah C. P. Williams |
Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors. |
Chemistry World June 4, 2008 Simon Hadlington |
Man-made protocell hosts DNA synthesis US researchers have taken a step towards creating a synthetic cell in the laboratory that could resemble the first primitive stirrings of life on Earth. |
Chemistry World January 20, 2011 Hayley Birch |
Programmable RNA promising for bio-compatible therapies Programmable nanostructures based on ribonucleic acid could be used as vessels for shipping therapeutic molecules into cells, according to US scientists. |
Chemistry World November 2006 Bea Perks |
Call That Chemistry? This year's Nobel prize in chemistry was a tour de force for crystallography, underscoring the vital role chemistry plays across the sciences. |
Reactive Reports Apr/May 2005 David Bradley |
At Last, the Structure of DNA Researchers have made a significant advance in our understanding of life's main molecule, using X-ray crystallography to determine the three-dimensional structures of nearly all the possible sequences of a macromolecule. |
HHMI Bulletin Winter 2013 Sarah C.P. Williams |
Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning. |
Technology Research News May 5, 2004 Kimberly Patch |
DNA Bot Targets Cancer Researchers from Israel have constructed a molecular-size computer that is programmed to find signs of cancer cells, and when they are present, dispense DNA molecules designed to eradicate those cells. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
Chemistry World October 4, 2006 Bea Perks |
Good Year for RNA Roger Kornberg, professor of structural biology at Stanford University, has been awarded the 2006 Nobel prize in chemistry for his work on the molecular basis of transcription. |
Scientific American January 2006 Charles Q. Choi |
Un-Killing the Messenger Processing bodies do more than serve as RNA trash bins in cells. Research now suggests that these P-bodies are less like junkyards and more like office centers, where messages are amassed, silenced and reactivated. |
Chemistry World September 5, 2011 David Bradley |
Spiders, Grubbs' and polymer-powered nanomotors A chemical spider that spins a polymer thread using a simple catalyst could drive a nanomotor, according to researchers at Pennsylvania State University, US. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Chemistry World July 17, 2012 Simon Perks |
Synthetic nanozymes silence hepatitis C Researchers at the University of Florida, US, have discovered that an artificial nanoparticle complex, known as a nanozyme, can help to treat viral infections by 'shutting off' their genetic material. |
Chemistry World January 11, 2008 John Bonner |
DNA Nanoparticles Detect Gene Expression US scientists have made nanoparticles from DNA that they say could be used to identify the genes being expressed in a single cell. |
Bio-IT World December 15, 2004 David A. Bumcrot |
Identifying RNAi Drug Candidates Breakthroughs in understanding RNA's extensive role in essential cellular processes have opened up the potential for a whole new class of drugs based on RNAi. |