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Chemistry World October 2, 2006 Bea Perks |
RNAi Pioneers Win Nobel Prize for Medicine Molecular biologists Andrew Fire and Craig Mello have been awarded this year's Nobel prize in physiology or medicine for their discovery of RNA interference. |
Chemistry World January 31, 2008 John Bonner |
RNAi Scores Victory Against Crohn's Disease in Mice Thousands of people suffering from the debilitating gut condition Crohn's disease could experience relief from their symptoms through a technique that blocks production of a key protein in the inflammation process. |
HHMI Bulletin Winter 2013 Sarah C.P. Williams |
Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Chemistry World November 2006 Bea Perks |
Call That Chemistry? This year's Nobel prize in chemistry was a tour de force for crystallography, underscoring the vital role chemistry plays across the sciences. |
Chemistry World April 20, 2009 James Urquhart |
New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought. |
Chemistry World November 27, 2007 James Mitchell Crow |
A Flare for Gene Silencing US scientists have developed nanoparticle probes coated with DNA that release fluorescent 'flares' when they silence genes inside cells. |
Bio-IT World December 15, 2004 William Marshall |
Applications of RNAi RNA interference is a highly coordinated gene regulatory mechanism that appears to be highly conserved across all metazoans studied thus far. |
Scientific American June 2005 JR Minkel |
RNA to the Rescue The spectacular discovery that a species of plant can summon up genes its parents have lost highlights biologists' increasing recognition of RNA as a more versatile and important molecule in its own right. |
Bio-IT World December 15, 2004 David A. Bumcrot |
Identifying RNAi Drug Candidates Breakthroughs in understanding RNA's extensive role in essential cellular processes have opened up the potential for a whole new class of drugs based on RNAi. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
Chemistry World April 28, 2008 Victoria Gill |
Gene silencing gets fat A team of researchers in the US has developed fat-like nanoparticles that can carry fragments of RNA into cells, bring treatments based on gene silencing a step closer. |
The Motley Fool July 11, 2007 Brian Orelli |
Everybody Loves RNAi Roche is the latest firm to (over)pay for the hottest new drug technology. Alnylam announced that it licensed some of its intellectual property to Roche for $331 million. Investors, take note. |
Chemistry World October 4, 2006 Bea Perks |
Good Year for RNA Roger Kornberg, professor of structural biology at Stanford University, has been awarded the 2006 Nobel prize in chemistry for his work on the molecular basis of transcription. |
Chemistry World January 25, 2010 Hayley Birch |
Stabilising RNAs enhances gene silencing in tumours South Korean scientists have found a way to stabilise therapeutic RNA molecules, using chemical modifications, so that they can be more smoothly trafficked into cells. |
Chemistry World March 21, 2010 Simon Hadlington |
Nanoparticles successfully deliver RNA interference in cancer patients The system aims to exploit the phenomenon of RNA interference, where short sequences of double-stranded RNA, called small interfering RNA or siRNA, can trigger the disruption of the manufacture of certain proteins in a cell. |
Chemistry World August 8, 2012 |
Protein Coat for Gene Therapy Kenneth Woycechowsky's group at the University of Utah has modified a non-viral protein so that it will carry RNA. |
The Motley Fool October 5, 2006 Ralph Casale |
RNAi: Nobel Prize-Winning Biotechnology While drugs based on RNAi knockdown technology may have the potential to become the next big thing in biotechnology, they are still a long way from becoming FDA-approved marketable entities. But it's never too soon to start keeping an eye on the future. Investors, take note. |
Bio-IT World July 15, 2003 Malorye Branca |
Silence Is Golden RNA interference's scientific, therapeutic, and economic potential is unquestionable, but some sticky questions still remain. |
Chemistry World November 5, 2007 Lewis Brindley |
Silencing the Pests Two teams of scientists have uncovered a new way to protect crops from two serious insect pests. The teams made use of a process called RNA interference to silence critical genes in the bodies of the insect larvae and stopped them growing. |
The Motley Fool September 28, 2007 Brian Orelli |
RNAi Doesn't Kill Mice After All From Merck, to AstraZeneca, to Novartis, big pharma continues to pump hundreds of millions of dollars into unproven RNAi technology. Investors, take note. |
Scientific American November 2007 Ed Regis |
The Forgotten Code Cracker In the 1960s Marshall W. Nirenberg deciphered the genetic code, the combination of the A, T, G and C nucleotides that specify amino acids. So why do people think that Francis Crick did it? |
HHMI Bulletin February 2011 Mitzi Baker |
When Worlds Collide The right time and place led to a new RNAi-like pathway in bacteria for biochemist Jennifer Doudna and geobiologist Jill Banfield. |
Chemistry World January 20, 2011 Hayley Birch |
Programmable RNA promising for bio-compatible therapies Programmable nanostructures based on ribonucleic acid could be used as vessels for shipping therapeutic molecules into cells, according to US scientists. |
Chemistry World October 31, 2008 Manisha Lalloo |
DNA-rewinding protein discovered US scientists have found an enzyme that rewinds sections of DNA whose strands have mistakenly come apart. |
Bio-IT World December 15, 2004 Nancy Weil |
Running Interference The revolution in RNA interference has galvanized basic research. Now, some biopharmas are pushing the technology from the laboratory to the clinic. |
Chemistry World August 7, 2008 Simon Hadlington |
RNA stops HIV in its tracks Scientists have successfully used a biochemical Trojan horse to smuggle killer sequences of RNA into immune cells to mug invading HIV, stopping infection in its tracks |
Technology Research News March 12, 2003 |
RNA forms nanomotor Researchers from Purdue University have constructed a tiny motor from DNA and RNA molecules. The device, fueled by ATP, which powers our own movements, could eventually power nanomachines. |
Pharmaceutical Executive October 1, 2008 |
The other half of an HIV mystery is solved When HIV infects a human immune cell, which of the cell's own genes play a role? |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Skin Sense An early question about aging skin led to answers on how cells code for their location. |
Bio-IT World July 2005 Kevin Davies |
MicroRNAs Alter Cancer Scene MicroRNAs (miRNAs) are tiny RNA molecules of about two-dozen nucleotides in length. While there have been hints that miRNAs might be associated with certain cancers, the new studies unequivocally show that to be the case. |
HHMI Bulletin Winter 2013 Megan Scudellari |
Tunneling Out A research team including HHMI investigator Melissa Moore at the University of Massachusetts Medical School has discovered an alternative passageway used by RNA -- protein complexes to exit the nucleus. |
Technology Research News June 16, 2004 |
Genes Automate DNA Machines Researchers have taken a step toward automating nanomachines with a method that allows instructions for a DNA-based machine to be contained in a gene, or another stretch of DNA. |
Chemistry World February 1, 2008 Lewis Brindley |
Genetic Code Read Directly From RNA Scientists have directly read the genetic code from a single strand of RNA for the first time, using a combination of powerful microscopes and laser spectroscopy techniques. |
HHMI Bulletin Aug 2011 Cassandra Willyard |
A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice. |
Bio-IT World April 15, 2003 Malorye Branca |
Beyond the Blueprint How will the wealth of data emanating from the human genome and allied technologies impact research on health and disease? |
Technology Research News January 12, 2005 |
RNA Tiles Form Nanopatterns Researchers have developed a method of coaxing artificial RNA molecules to self-assemble into specific shapes, much like a jigsaw puzzle automatically assembling. The structures could eventually be used as templates for nanochips, nanocircuits and nanocrystals |
Bio-IT World July 2005 David M. Evans |
Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior. |
Chemistry World November 16, 2006 Simon Hadlington |
Gene-Reading Enzyme Catapulted by Scrunch Power Two teams of researchers have solved a conundrum that has baffled molecular biologists for 20 years -- how the enzyme responsible for `reading' genes can release itself from the portion of DNA to which it initially binds extremely tightly. |
Chemistry World September 23, 2009 Simon Hadlington |
Direct route to RNA sequences Scientists in the US appear to have cracked a major problem in molecular biology: how to sequence single molecules of RNA directly. |
Bio-IT World February 18, 2004 |
Pathology Goes Molecular New technologies are enabling clinical diagnostic laboratories to pave the way toward more personalized cancer therapies |
Chemistry World February 27, 2006 Michael Gross |
A DNA Switch for RNA Folding Researchers have equipped a large RNA domain with a DNA switch, which they say can fold or unfold the RNA molecule at will. |
Pharmaceutical Executive July 30, 2007 |
Tomorrow's Drugs A look at the seven top therapies and technologies vying to deliver the next generation of drugs. |
Scientific American January 2006 Charles Q. Choi |
Un-Killing the Messenger Processing bodies do more than serve as RNA trash bins in cells. Research now suggests that these P-bodies are less like junkyards and more like office centers, where messages are amassed, silenced and reactivated. |
HHMI Bulletin Spring 2013 Sarah C.P. Williams |
Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases. |
Chemistry World February 2011 |
My hero: The greatest influences of chemistry Nobel laureates Aaron Ciechanover, who won the 2004 Nobel prize in chemistry with Avram Hershko and Irwin Rose for the discovery of ubiquitin-mediated protein degradation, talks about Charles Darwin. |
Chemistry World June 12, 2013 Sarah Houlton |
No small success Chad Mirkin has been the driving force behind four spin-out nanotechnology companies, and has more than 850 patents to his name. Yet he describes himself as something of an accidental chemist. He is particularly proud of spherical nucleic acids. |
Chemistry World July 2010 Hayley Birch |
Special Report: Health breakthroughs of the decade New discoveries have been made with cancer vaccines, genomics, statin drugs, allosteric modulators, and RNA interference during the last decade. |
Chemistry World June 9, 2008 Simon Hadlington |
Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes. |
Chemistry World May 17, 2007 Richard Van Noorden |
Bacterial Navigation Reprogrammed U.S. scientists have forced bacteria to follow new chemical signals by tweaking the bugs' natural guidance system. |