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Chemistry World June 24, 2010 Phillip Broadwith |
Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists. |
Chemistry World November 3, 2011 David Bradley |
Faster Synthesis of Fluorine Radioisotope Imaging Agents A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging. |
Chemistry World August 24, 2010 Lewis Brindley |
A better way to add radioactive fluorine Making compounds that contain the useful radioisotope fluorine-18 ( 18F) could be much easier in future, say researchers in the UK and Finland. |
Chemistry World January 23, 2012 James Urquhart |
Simple One Stop Shop for Difluoromethylation A new process developed by researchers opens the way for adding difluoromethyl (CF 2H) groups to drugs and agrochemicals in order to enhance their properties. |
Chemistry World August 15, 2011 Simon Hadlington |
Trifluoromethylation Made Easy US researchers have discovered a simple, low-cost way to add fluorine atoms to heteroaromatic rings. |
Chemistry World March 19, 2009 Manisha Lalloo |
Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings |
Chemistry World August 29, 2008 Fred Campbell |
Breaking the bonds of global warming US scientists have managed to prise apart the highly unreactive carbon-fluorine bond at room temperature, potentially paving the way to the efficient disposal of hydrofluorocarbons -- highly stable and long-lived greenhouse gases. |
Chemistry World September 18, 2015 Tim Wogan |
Shining a light on amine synthesis A new method for site selective amination of aromatic organic compounds has been developed by researchers in the US. |
Chemistry World January 2011 |
Column: In the pipeline Some medicinal chemists can't get enough fluorines in their molecules. The love-hate relationship is explained. |
Chemistry World July 3, 2015 Andy Extance |
Copper catalysis overcomes double bond trouble Some carbon-carbon double bonds seem too unreactive for synthetic use -- but that's just how chemists in the US are now exploiting them. |
Chemistry World June 2008 Sarah Houlton |
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success |
Chemistry World January 11, 2013 Marie Cote |
Following her passion Veronique Gouverneur is professor of chemistry at the University of Oxford, UK. She investigates fluorine chemistry and is working on developing novel synthetic methodologies for the preparation of fluorinated targets. |
Chemistry World September 13, 2012 Ian Le guillou |
Fluorination via porphyrin A manganese porphyrin has been used to selectively fluorinate sp 3 carbon -- hydrogen bonds using silver fluoride as a source of fluorine. |
Chemistry World April 28, 2011 Simon Hadlington |
New method for aromatic coupling Chemists in Switzerland have developed a way to couple aromatic rings through the Friedel-Crafts mechanism - something many people would have believed impossible. |
Chemistry World May 31, 2009 Nina Notman |
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. |
Chemistry World June 23, 2011 Simon Hadlington |
Breaking the carbon-fluorine bond US chemists have discovered a new way to break the bond between carbon and fluorine atoms - the strongest carbon bond there is. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World June 14, 2006 Simon Hadlington |
Natural Metabolism of Fluorine Scientists have isolated a cluster of bacterial genes responsible for the biochemical processing of fluorine. The research follows the discovery of a unique enzyme that incorporates inorganic fluoride into organic metabolites. |
Chemistry World June 15, 2009 Matt Wilkinson |
Concert arranges billion dollar GSK deal US-based Concert Pharmaceuticals has inked its first commercialization deal granting GlaxoSmithKline access to six deuterium-modified drugs |
Chemistry World June 5, 2006 Simon Hadlington |
The Attraction of Gold for Gold Researchers are unravelling some of the fundamental chemistry surrounding a key but poorly understood aspect of the coordination chemistry of gold -- the weak `aurophilic' interactions between adjacent atoms of Au(I) in organic complexes. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World January 20, 2010 James Urquhart |
Disilicate synthesis success A compound containing a stable silicon-silicon bond between two negatively charged pentacoordinated silicon atoms - silicates - has been synthesized and isolated for the first time by Japanese researchers. |
Chemistry World March 2012 |
Column: In the pipeline Drug discovery requires experimentation, says Derek Lowe. But chemists can be reluctant to stray from the elements they know and love |
Chemistry World December 19, 2010 Simon Hadlington |
Novel route to key aromatics US chemists have found a new way to create aromatic compounds from straight chains of hydrocarbons by using an iridium-based catalyst. |
Chemistry World September 12, 2013 Andy Extance |
Sulfur difluoride dimer exposes bonding strangeness Calculations on unusual bonding in the sulfur difluoride dimer FSSF 3 have provided evidence to help explain why some compounds don't follow long-established chemical rules. |
Chemistry World September 28, 2015 Karl Collins |
A witches' brew for trifluoromethylation Trifluoromethylating phenols is one example of a reaction that would be incredibly useful when attempting to tune the chemical and biological properties of molecules for pharmaceutical and agrochemical research. |
Chemistry World December 15, 2010 Hayley Birch |
New technique probes electron properties of individual atoms A new, low voltage electron microscopy technique allows scientists to discriminate not just between atoms of different elements but between atoms of the same element in different electronic states. |
Chemistry World November 18, 2014 Katrina Kramer |
Molecules: the elements and the architecture of everything Molecules is a serious attempt to explain the world of chemical compounds to the reader without assuming previous science knowledge. |
Chemistry World April 15, 2010 Simon Hadlington |
Lead joins the aromatic ring club Scientists in Japan have successfully incorporated an atom of lead into an aromatic molecule - the heaviest metal so far to be 'aromatised'. |
Chemistry World March 3, 2010 Jon Cartwright |
Hydrocarbon turns superconductor Researchers in Japan have created the first superconducting material based on a molecule of carbon and hydrogen atoms. |
Chemistry World January 13, 2011 Sarah Corcoran |
Unclogging the problems of flow chemistry US scientists have found a way to stop solid byproducts clogging channels in continuous flow reactors, a problem that has hampered their progress for use in manufacturing pharmaceuticals. |
Chemistry World April 4, 2013 Phillip Broadwith |
A solution to fluoronium riddle The first evidence for hypervalent fluorine cations, or fluoronium ions, in solution has been found by US chemists. |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. |
Chemistry World August 2009 Derek Lowe |
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder |
Chemistry World May 28, 2015 Matthew Gunther |
Purely inorganic aromatic ion synthesized Scientists in the US have successfully synthesized an aromatic ion made from only nitrogen and phosphorus. The anion is a rare example of a stable aromatic species containing no carbon atoms. |
Chemistry World September 25, 2015 Derek Lowe |
Spice up your compounds You and your team are optimizing a lead compound, as medicinal chemists are wont to do -- varying its structure to improve its potency, selectivity and other properties. |
Chemistry World January 25, 2013 Derek Lowe |
Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers? |
Chemistry World July 16, 2009 Simon Hadlington |
Strange vibrations Researchers in Taiwan have shown that in a relatively simple molecular system the induced vibrations can inhibit the breaking of the bond and slow the reaction down. |
Chemistry World March 10, 2011 Kate McAlpine |
Aerosol data from BP spill Analysis of atmospheric data suggests that emissions of intermediate volatile organic compounds and semi-volatile organic compounds were low compared with those of volatile organic compounds. |
Chemistry World October 9, 2014 Katrina Kramer |
Largest Mobius molecule synthesized Researchers from Korea and Japan have put a new twist on aromaticity, synthesizing the largest Mobius aromatic molecule to date. |
Technology Research News May 4, 2005 |
Noisy Snapshots Show Quantum Weirdness Researchers have devised a relatively simple way to detect a pair of entangled, or linked atoms. The detection ability advances quantum computer and quantum communications research. |
Chemistry World July 11, 2012 Neil Withers |
Fluorine Finally Found in Nature Traces of elemental fluorine, F 2, have been found in calcium fluoride minerals by German chemists, who suggest that it's produced by uranium also found in the rock. |
Technology Research News August 11, 2004 |
Single gold atoms altered The gold atom, positioned on an ultrathin film of sodium chloride, remained stable during the operation, despite the change in charge. |