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Bio-IT World
September 2006
Kevin Davies |
Pfizer's Global Survey of Pharmacological Space The pharma blends knowledge, computational chemistry and research informatics to build a unified database. Gathering all the data in one place offered greater control for indexing and data retrieval and management, enabling Pfizer scientists to perform global mapping.   |
Chemistry World
March 4, 2015
Philip Ball |
Program ready to weed out tough drug leads A method for reliably predicting how well a candidate drug molecule will bind to its target receptor would allow libraries of molecules to be screened on the computer, without having to synthesize them all. |
Bio-IT World
December 10, 2002
Hillel Alpert |
Bio-IT Shines Bright in Israel Companies such as Quark and Pharmos are still flourishing as other industries decline in this country torn by conflict. |
Chemistry World
September 29, 2015 |
Navigating chemical space How big is chemistry? I don't mean how important is it, or how many people do it, but rather, how many molecules are there that we could make? |
Bio-IT World
April 2007
Vicki Glaser |
Software Solutions for Medicinal Chemistry Driven by advances in chemical synthesis, instrumentation, and high-throughput and high-content screening technology, medicinal chemistry's transition from an art to a science is benefiting from a wealth of new software products, spanning both bio- and cheminformatics. |
Bio-IT World
November 12, 2002
James Golden |
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success. |
Chemistry World
December 2008 |
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. |
Bio-IT World
June 17, 2004
John Garvey |
Rational Decisions As companies in the computationally guided rational drug design sector mature, they should be more sure of the boundaries that surround their proprietary technologies. |
Chemistry World
January 19, 2011
Jon Cartwright |
Modified protein binders give shortcut to drugs The method, which involves attaching polypeptides to the binders, could help reduce the work required to develop protein binders into safer drugs. |
Bio-IT World
December 15, 2004
Kevin Davies |
Into the Valley of Innovation An interview with president and CEO Curt Carlson of research hothouse SRI International on new technology and accelerating drug development. |
Chemistry World
November 2, 2009
Simon Hadlington |
New way to find drugs' unintended targets Researchers in the US have devised a new way to predict 'off-target' effects for pharmaceutical drugs. |
Bio-IT World
October 10, 2003
Jeffrey Skolnick |
Protein Structure Prediction in Drug Discovery Indications are that structure prediction can assist in the automated assignment of proteins to known pathways. |
Reactive Reports
Issue 41
David Bradley |
Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip. |
Bio-IT World
August 18, 2004
Kevin Davies |
In Praise of Chemical Diversity How to build better small-molecule libraries. |
Chemistry World
July 26, 2012
Derek Lowe |
Screen shots You might not think that the makeup of a compound screening collection could set off many arguments, but there are a few issues there that will do the trick almost every time. |
Chemistry World
June 23, 2015
Derek Lowe |
Missing the target There are enzymes that no mustard has ever cut, to steal a phrase from science fiction author James Blish. Phosphatases, the flip side of kinase activity, are a perfect example. |
Chemistry World
April 25, 2013
Andreas Barth |
Chemical bibliometrics Counting compounds instead of publications and citations opens new perspectives for data-based scientific discovery and it can complement and stimulate both experimental and theoretical research. |
Bio-IT World
September 11, 2003
Mark D. Uehling |
Fishing Chips The next generation of protein microarrays from the likes of Protometrix and Molecular Staging may threaten the early leads of Biacore and Ciphergen -- and work so well that drug companies won't want them. |
Chemistry World
December 2007
Derek Lowe |
Column: In the Pipeline The challenge of biologics. |
Bio-IT World
June 12, 2002
Karen Hopkin |
Computational Biologists Join the Fold CASP5 competitors compare the best algorithms for modeling the 3-D structure of proteins -- an exercise that could lead to new insights into the pathogenesis and treatment of disease. |
Chemistry World
October 2008
Derek Lowe |
Column: In the pipeline The author seeks a cure for 'compound bloat' |
Bio-IT World
August 15, 2005
Robert M. Frederickson |
What's 'Post' About Postgenomic? Bioinformatics tools can help organize and study genomic sequences that were discovered in the '90s. The tools help with tasks like analyzing gene expression, predicting protein structure and function, and establishing networks of interacting protein in cells. |
Bio-IT World
August 18, 2004
John Russell |
A Dozen Sparkling Gems A snapshot of deserving Best Practices Awards entries: Locus Pharmaceuticals... Children's Memorial Hospital, Chicago... XOMA... University of Texas Health Science Center... etc. |
HHMI Bulletin
February 2011
Michele Solis |
Right Before Your Eyes Coupling protein sequence to function, thousands of variants at a time. |
