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Chemistry World May 6, 2008 James Mitchell Crow |
Building Peptides From the Wrong End UK chemists have cracked a long-standing problem in peptide synthesis that has prevented amino acid chains being grown from both ends. The insight could open up efficient ways to make peptide-based drugs. |
Chemistry World July 2, 2014 Tim Wogan |
Miller's forgotten experiments point to primitive protein genesis Stanley Miller's experiments are still adding to our understanding of prebiotic Earth. |
Chemistry World August 2, 2011 Phillip Broadwith |
Protein synthesis hijacked to turn out cyclic peptides Japanese researchers have developed a way of reprogramming the genetic code and using bacteria to make and screen huge libraries of cyclic peptides using unnatural amino acids. |
Chemistry World March 16, 2014 Simon Hadlington |
Short peptides self-assemble into a catalyst Researchers in the US have created catalysts from peptide chains that are only seven amino acids long. |
Geotimes October 2004 Laura Stafford |
Volcanic gas and early life Researchers have combined carbonyl sulfide with free amino acids in a reaction that created di-, tri- and tetra-peptides. The experiment was conducted under a variety of conditions meant to simulate Earth's early atmosphere. |
Chemistry World February 7, 2007 Bea Perks |
Protein's Non-Natural Alternative Beta peptides are of interest because of what they can tell researchers about protein folding in general. Now, chemical biologists have built what they say is a 'remarkably protein like' structure from beta peptides. |
Chemistry World July 26, 2007 Richard Van Noorden |
Shortcut Protein Synthesis Ditches Amino Acids Chinese chemists have demonstrated a speedy way to make polypeptides by avoiding the costly tedium of linking together amino acids. |
Chemistry World June 17, 2013 Eleanor Merritt |
Switching chirality in amino acids An international team of scientists has developed a purely chemical approach to interconvert L- and D-amino acids. This method could rival enzymatic routes used in industry, and enable cheaper production of some pharmaceuticals. |
Chemistry World October 16, 2008 Hayley Birch |
Miller's legacy: new clues to origins of life Scientists have re-examined dried residues in 50-year-old vials from classic 'primordial soup' experiments to glean new information about how life originated on Earth. |
Chemistry World October 9, 2006 Michael Gross |
Miniature Microbicides Researchers have created miniature antimicrobial peptides that contain only four (as opposed to the usual 12-50) amino acid residues combined with a fatty acid. |
Chemistry World June 11, 2009 James Urquhart |
Enzyme-free assembly of DNA-like molecules US scientists have developed a simple peptide nucleic acid system that self-assembles and adapts to new instructions without enzymes. |
Chemistry World September 12, 2010 Mike Brown |
Comet shockwaves helped stimulate life on Earth The shock waves caused as comets hit the early Earth could have helped promote the formation of amino acids and the early building blocks of life, say US researchers. |
Chemistry World March 17, 2015 Andy Extance |
Reaction map suggests meteorite chemistry route to life UK chemists have found a reaction network that they believe shows that 'pretty much everyone' working on life's molecular origins is wrong -- but also 'right, in a sense'. |
Chemistry World January 19, 2010 Simon Hadlington |
New 'click' reaction to modify proteins Chemists in the US have discovered a new way to attach small molecules to proteins and peptides under mild, aqueous reaction conditions. |
Chemistry World January 10, 2013 Laura Howes |
Rotaxane mimics ribosome to spin out peptides The field of molecular machines has taken a new bio-inspired turn to assemble another molecule, in this case linking up individual amino acids into a peptide. |
Chemistry World June 4, 2008 Lewis Brindley |
Peptide printer goes into overdrive Synthesizing arrays of short peptides could soon be as easy as printing them out - thanks to the development of a modified laser printer that uses amino acids instead of colored ink. |
Chemistry World September 7, 2014 Michael Gross |
Bringing chemical synthesis to the masses The promise of a novel approach to building chemical libraries, which only requires simple building blocks in water, without any additional reagents or sample preparation, is inspired by nature. |
Chemistry World May 12, 2008 Simon Hadlington |
'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria. |
Chemistry World September 16, 2014 Patrick Walter |
Computer simulations point to formamide as prebiotic intermediate in 'Miller' mixtures Formamide may have played a key role in the genesis of life |
Chemistry World March 21, 2011 Michael Gross |
Origin of life experiments revisited Modern analysis of forgotten samples has given chemists in the US additional insights the origins of life on Earth. |
Chemistry World March 2, 2007 Philip Ball |
Giving Life a Hand Why are proteins left-handed and nucleic acids right-handed? Once offered only a few sketchy theories, scientists have found more alternatives for creating homochirality. |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Chemistry World August 28, 2011 Simon Hadlington |
Synthetic self-assembling collagen for tissue engineering US researchers have succeeded in making the most realistic synthetic collagen to date. |
Chemistry World November 1, 2009 Hayley Birch |
How light gave life a helping hand A new theory for how 'handedness' in organic molecules evolved has been proposed by Dutch scientists. |
Chemistry World August 13, 2015 Heather Powell |
Study probes role of chemical corruption in origin of life Researchers are incorporating what they describe as defective compounds into their experiments to help them understand how the first molecules of life formed. |
Chemistry World April 8, 2008 Mark Peplow |
Meteorite Source for Life's Handedness Scientists have long speculated that life's preference for left-handed amino acids may have been triggered by compounds brought to Earth by meteorites. Now they've shown exactly how two crucial steps in this process could happen. |
Chemistry World February 11, 2013 Philip Ball |
A (chemical) potential theory of life's origin This theory says that life arose at hydrothermal vents, not merely because these provide heat and the ingredients for making complex organics but because they create sustained gradients of ion concentration. |
Chemistry World August 20, 2008 |
Spying on Self-Assembly Proteins attaching to gold nanoparticles don't mill around randomly, but organise into clusters, according to UK scientists who say they have for the first time spied in detail peptides assembling on a surface. |
Chemistry World October 8, 2008 Sarah Houlton |
Artificial protein chemistry licensed to industry UK researchers are licensing to industry their method of making artificial proteins by chemically modifying individual amino acid structures. |
Chemistry World January 13, 2012 Helen Potter |
Mineral regulates early metabolism Chinese scientists have taken a step towards further understanding the reactions that led to the origin of life by showing that a crucial metabolic process can be photocatalysed on the surface of a common mineral. |
Chemistry World November 26, 2010 Amaya Camara-Campos |
Enriching the origin of life theory An enantioenrichment of the amino acid valine, which could shed light on the origin of chirality on Earth, has been achieved by scientists in Spain. |
Chemistry World March 30, 2011 Hayley Birch |
Amino acid synthesis hints at how the genetic code expanded The detailed pathway for the biosynthesis of pyrrolysine - the 22nd and latest amino acid to be discovered - has been outlined by US researchers. |
Chemistry World June 16, 2014 James Urquhart |
Handshake assembles new emulsions All it takes to make new stable emulsions with tuneable and novel properties is to give a simple mixture of water, solvent and peptide derivatives a quick shake by hand. |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. |
Chemistry World August 7, 2011 Phillip Broadwith |
Possible Origin of Chirality in the Rna World Given a tiny push one way or the other, simple racemic precursors can lead to the chiral building blocks of RNA using a combination of chemical and physical factors. |
Chemistry World December 8, 2008 Hayley Birch |
Meteorites hitting oceans may have kick-started life Japanese scientists have done laboratory experiments to test the idea. |
Chemistry World May 12, 2010 Phillip Broadwith |
Tying up spider silk's loose ends The way spider silk proteins can be stored as a fluid but spun instantly into fibres is all down to their end parts, European scientists have discovered. |
Chemistry World December 20, 2007 Richard Van Noorden |
Off-the-Peg Organic Synthesis Goes Commercial Chemists have created an efficient way to make small molecules by repeatedly using just one coupling reaction to clip together pre-prepared chemical fragments is going commercial. |
Chemistry World April 12, 2012 Alisa Becker |
Nanoscale engineering of wound beds A collagen-binding peptide with applications in wound healing has been developed by scientists in the US. |
Chemistry World October 14, 2009 James Urquhart |
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts. |
Chemistry World February 3, 2012 Simon Hadlington |
Toxic mushroom behind Chinese deaths unmasked Chinese scientists believe they have identified the toxic assassins responsible for the mysterious deaths of hundreds of people in one of the country's provinces over the past 30 years. |
Chemistry World October 26, 2006 Victoria Gill |
Volcanoes Reveal the Secret of the Origin of Life Life began with a chemical reaction under the sea over four billion years ago. That is the claim of a German scientist whose team has recreated a crucial part of the reaction, synthesizing all the necessary ingredients for a living organism. |
Chemistry World November 5, 2015 Emma Stoye |
Unnatural nanoreactor puts click reaction in the spotlight A protein 'nanoreactor' that can monitor a click chemistry reaction at the level of single molecules has been created by adding an unnatural amino acid to a nanopore. |
Geotimes November 2004 Jay Chapman |
Impacting the Origin of Life Impact events and meteorite strikes are often associated with mass extinctions and widespread devastation. But, despite this destructive reputation, impact events may have played a role in the evolution of life, according to several new studies. |
Chemistry World September 25, 2014 Simon Hadlington |
First interstellar sighting of a branched alkyl molecule The radiotelescope in Atacama, Chile, has found the first branched molecule ever seen in interstellar space |
Pharmaceutical Executive November 1, 2006 |
Thoughtleader: Making Things Stick Ambrx has created the "glue" that allows researchers to attach activity-enhancing molecules to amino acids where they couldn't before. |
Chemistry World December 20, 2012 Laura Howes |
Cutting edge chemistry in 2012 This year saw more work probing the nature of bonding. In Germany, Holger Braunschweig found that reacting a bis(N-heterocyclic carbene)-stabilized tetrabromodiborane with sodium naphthalene gave diborene or diboryne compounds with the world's first stable boron -- boron triple bond. |
Chemistry World October 27, 2014 Tim Wogan |
Folding rules used to build unnatural proteins Scientists in the UK and US have designed and synthesized unnatural protein structures, using theoretical calculations to explore the factors affecting protein folding and stability. |
Chemistry World March 4, 2011 Russell Johnson |
Tracking the early stages of Alzheimer's disease UK researchers can track the early steps of formation of peptide clumps linked to Alzheimer's disease using the peptide's fluorescent ability. This could help design effective therapies for the disease at an early stage. |
Chemistry World June 17, 2012 Jon Evans |
Anti-social amino acids gang up Previously thought to be purely the preserve of proteins and peptides, scientists have discovered that the amino acid phenylalanine can form the toxic amyloid fibrils that are a hallmark of diseases such as Alzheimer's and Parkinson's. |