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Chemistry World November 2010 |
Carbon Couplers Take the Prize Three giants of organic chemistry, who pioneered palladium-catalysed cross coupling reactions, have shared this year's Nobel prize. |
Chemistry World October 6, 2010 Simon Hadlington |
Trio share Nobel for palladium-catalysed cross-coupling Richard Heck of the University of Delaware in Newark, US, Ei-ichi Negishi of Purdue University, US, and Akira Suzuki of Hokkaido University in Japan, independently developed palladium-catalysed cross-coupling reactions as a way to forge new carbon-carbon bonds with precision |
Chemistry World February 6, 2011 Laura Howes |
Cells as test tubes Chemists have used living cells as test tubes to carry out chemical reactions never before seen within living cells. |
Chemistry World May 24, 2007 James Mitchell Crow |
Palladium Coupling in Fewer Steps Look out Suzuki - Canadian chemists have successfully joined up simple benzene ring-like aromatics without any pre-activation. |
Chemistry World August 16, 2009 Tom Bond |
Catalyst free carbon-carbon bond formation The method offers an environmentally friendly way to form one of the most important bonds in organic synthesis. |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World April 12, 2012 Simon Hadlington |
Recruiting electrophiles for organic cross-coupling Chemists in the US have taken an unconventional approach to carbon cross-coupling and in doing so have potentially opened the door to the rapid and efficient synthesis of a wide range of organic compounds. |
Chemistry World June 2007 Dylan Stiles |
Opinion: Bench Monkey This PhD student takes an organic chemist's tour around the periodic table. |
Chemistry World June 21, 2012 Laura Howes |
Chemistry nobel laureate William Knowles dies Knowles shared the Nobel prize in Chemistry in 2001 with Ryoji Noyori and Barry Sharpless, for their work in asymmetric catalysis. Noyori and Knowles shared half the prize for their work on asymmetric hydrogenation reactions. |
Chemistry World August 2008 |
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? |
Chemistry World June 24, 2010 Phillip Broadwith |
Aryl rings get a fluorine fix A mild and effective method for coupling trifluoromethyl groups on to aryl rings has been developed by US chemists. |
Chemistry World August 11, 2010 Simon Hadlington |
Non-metal-catalysed C-C coupling Chinese chemists have successfully coupled aromatic molecules without the use of a transition metal catalyst - something that people have been trying to do for years with little success. |
Chemistry World August 22, 2014 Derek Lowe |
Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today. |
Chemistry World January 25, 2013 Derek Lowe |
Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers? |
Chemistry World March 20, 2008 James Mitchell Crow |
Surfactants Help Reactions Work in Water Scientists have discovered a surfactant that allows the catalytic organic reactions commonly used to assemble organic structures such as drug molecules to be run in water. |
Chemistry World April 7, 2015 Hugh Cowley |
The Goldilocks of heterogeneous catalysis An international team of scientists has tethered palladium to a metal -- organic framework support using thiol groups normally associated with catalyst poisoning |
Chemistry World July 17, 2014 Karl Collins |
Organic chemistry: a mechanistic approach Aimed at undergraduate chemistry students, this relatively succinct text begins with the fundamentals of molecular structure and introduces the concept of molecular orbitals early. |
Chemistry World June 1, 2012 Mike Sutton |
A reluctant chemist A century after Francois Auguste Victor Grignard's Nobel prize, organic chemists are still using the reagents he developed. |
Chemistry World May 8, 2012 Phillip Broadwith |
Keep stirring that Suzuki The shape of your reaction vessel can influence the behavior of organotrifluoroborate compounds in Suzuki cross-coupling reactions, say chemists in the UK. |
Chemistry World November 2007 |
Book Reviews A review of books on: good clinical & laboratory practices, green chemistry, environmental chemistry, organic reactions in water, universal asymmetry, and molecular models for fluids. |
Reactive Reports December 2006 David Bradley |
Dick Wife An interview with the chemical IT scientist and co-founder of SORD, a scientific publishing company that seeks to solve the problem of organizing the myriad of undocumented chemistry and the chaotic mess of the commercial database. |
Chemistry World December 18, 2013 Emma Stoye |
Chemistry Nobel winner John Cornforth dies Sir John Cornforth, joint winner of the 1975 Nobel prize in chemistry, has died aged 96. He is best known for his work on the stereochemistry of enzyme-catalyzed reactions, including the biosynthesis of cholesterol. |
Chemistry World March 19, 2009 Manisha Lalloo |
Copper catalysts give meta aromatics UK Researchers have discovered that, simply by using a copper catalyst, they are able to perform tricky substitution reactions at a difficult position on benzene rings |
Chemistry World June 8, 2014 David Bradley |
Carbon--carbon couplings go 3D Chemists have devised a new stereospecific coupling reaction for electron-rich aromatics using secondary and tertiary boronic esters that works under mild conditions. |
Chemistry World April 10, 2008 Mark Peplow |
'Pot-in-a-Pot' Technique Makes Impossible Cascade Reactions Easy A simple technique that nests a series of reaction vessels could help chemists avoid the tedium and expense of purifying organic compounds after each step of a long synthesis. |
Chemistry World April 29, 2015 Emma Stoye |
Wieland's chemistry Nobel to be sold at auction The chemistry Nobel prize awarded to German chemist Heinrich Wieland in 1927 has been put up for auction at Nate D Sanders in Los Angeles, US, with a starting price of $325,000. |
Chemistry World July 9, 2012 Phillip Broadwith |
'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom. |
Chemistry World September 18, 2015 Tim Wogan |
Shining a light on amine synthesis A new method for site selective amination of aromatic organic compounds has been developed by researchers in the US. |
Chemistry World September 26, 2012 Derek Lowe |
Under pressure Someone interviewing for a synthetic chemistry position had better know his or her organic chemistry. It's fair to ask questions that will make sure of that. But does a candidate need to know the curly-arrow details of reactions that they'll never run? |
Chemistry World June 7, 2009 Phillip Broadwith |
Pd(III) catalysis insight The discovery of a bimetallic palladium(III) complex that can catalyse the formation of carbon-heteroatom bonds adds a new facet to our understanding of the chemistry of one of the most widely-used metals in catalysis, say US chemists. |
Chemistry World November 25, 2014 James Urquhart |
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. |
Chemistry World March 22, 2012 Ross McLaren |
Back to the future: old reactions to help the new Researchers from the US have delved into the history of organic chemistry to help chemists better predict the effect that functional groups will have on one another within a molecule. |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. |
Chemistry World June 19, 2013 John Hayward |
Science of synthesis workbench edition: water in organic synthesis If a chemist is looking to do chemistry in (or on) water at the bench, Water in organic synthesis by Shu Kobayashi will be their guide. |
Chemistry World May 22, 2015 James Urquhart |
Complex amines made easy (and cheap) Phil Baran's lab at the Scripps Research Institute, La Jolla, has come up with a protocol that repurposes two readily available and inexpensive feedstock building blocks; olefins and nitroarenes, via iron-catalysed cross-coupling. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World November 2007 Derek Lowe |
Column: In the Pipeline Chemists are finally going with the flow. |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. |
Chemistry World June 2011 |
Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan. |
Chemistry World February 2, 2011 Elinor Richards |
Gold going it alone Spanish scientists have proved that gold alone can catalyse cross-coupling reactions following a claim made last year that palladium impurities in the gold are essential for the catalysis. |
Chemistry World April 30, 2015 Rebecca Trager |
Anton Toutov: The power of potassium Toutov says the potassium catalyst he has developed costs only about $30 per mole, or less. 'It is safer and non-toxic, and a lot more cost-effective,' he states. |
Chemistry World July 1, 2012 Paul Docherty |
Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity. |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries. |
Chemistry World March 2006 |
Flashback 60 Years Ago: US chemist Gilbert Newton Lewis died... 90 Years Ago: Christian Boehmer Anfinsen was born in Pennsylvania... 95 Years Ago: Jacobus Henricus van't Hoff died... etc. |
Chemistry World October 12, 2011 Joanne Thomson |
Hot Chemistry Temperature played a crucial role in David MacMillan's decision to study chemistry. |
Chemistry World September 4, 2008 Fred Campbell |
Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot. |
Chemistry World December 13, 2009 Lewis Brindley |
Breaking the strongest bonds Chemists have uncovered a way to sever two of the strongest bonds in chemistry - in dinitrogen and carbon monoxide - and make useful organic compounds. |
Chemistry World September 9, 2011 James Mitchell Crow |
High-throughput catalyst screening for the masses Using nothing more than the standard chemistry lab equipment, researchers in the US have successfully turned the discovery of new catalytic reactions into a high-throughput process. |
Chemistry World November 1, 2012 Laura Howes |
Shining new light on the Ullmann reaction Ullmann C -- N coupling -- a copper mediated carbon -- nitrogen coupling reaction used to create arylamines -- is one of the most widely used reactions in the pharmaceutical industry. |