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Chemistry World December 23, 2015 Karl Collins	Scratching chiral surfaces There are numerous challenges to developing reactions that exploit chiral surfaces, or employ molecular modifiers (ligands) to create a chiral surface environment and control the stereoselectivity of a transformation.
Chemistry World April 1, 2014 Karl Collins	Reduced to clear Reducing amides to primary alcohols may instinctively seem like a simple functional group transformation. But as undergraduate chemists soon find out, this unfortunately isn't the case.
Chemistry World February 27, 2012 Phillip Broadwith	Bending carbonyl reactivity rules Belgian chemists have uncovered a method to bypass the standard reactivity hierarchy of carbonyl compounds, allowing a ketone or ester to be reduced in the presence of a more reactive aldehyde.
Chemistry World June 2008 Paul Docherty	Column: Totally Synthetic Harvard University's David Evans is renowned for his prowess with an aldol reaction, and he has used the endlessly flexible transformation to make a diverse range of natural products.
Chemistry World May 30, 2013 Andy Extance	Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity.
Chemistry World March 2011 Paul Docherty	Column: Totally Synthetic Discovered independently by two chemists in the 1870s, it's remarkable that 140 years later, science is still tweaking and improving the aldol reaction.
Chemistry World February 21, 2008 Lewis Brindley	Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals.
Chemistry World November 7, 2014 Katrina Kramer	Stressed ligands switch catalysis selectivity Researchers have discovered that enantioselectivity in palladium-catalyzed reactions depends on the ligand's intramolecular strain.
Chemistry World July 26, 2007 Tom Westgate	Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds.
Chemistry World May 9, 2010 Phillip Broadwith	Iron catalyst breaks the mold An iron catalyst that is not only greener than many of its precious metal competitors, but also catalyses reactions that they can't, could open new avenues in transition metal catalysis, say Chinese researchers.
Chemistry World January 8, 2014 Karl Collins	Oxidation station Small molecules are making significant inroads -- with reactivity and selectivity approaching levels previously thought unachievable.
Chemistry World March 24, 2015 Karl Collins	Back to basics for silylation While silicon is probably most familiar in organic synthesis as part of protecting groups, its utility extends much further.
Chemistry World September 22, 2015 Andy Extance	Firming COFs up takes Michael reaction catalysis forward By making formerly fragile covalent organic frameworks resistant to harsh conditions, researchers have created what they think could be a powerful new catalyst concept.
Chemistry World September 2011 Paul Docherty	Column: Totally Synthetic Corey Stephenson of Boston University is an expert a type of reaction called photochemical reduction-oxidation. He has charmed photons into performing many chemical tricks, but one is a photoredox dehalogenation using blue light and a ruthenium bipyridyl catalyst.
Chemistry World April 25, 2014 Derek Lowe	Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.
Chemistry World January 2012 Paul Docherty	Column: Totally Synthetic What a Japanese team demonstrates in this synthesis of dragmacidin D is the state of the art, uniting all the key fragments using C-H bond couplings.
Chemistry World November 2010 Paul Docherty	Column: Totally Synthetic Perhaps the most familiar (and dull - they do say that familiarity breeds contempt.) chemical reaction to medicinal chemists is the amide bond formation.
Chemistry World August 22, 2014 Derek Lowe	Death of a reagent Anyone who's been practicing organic chemistry for a while can think back to reactions and reagents that were once in far wider use than they are today.
Chemistry World May 29, 2013 Paul Docherty	Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.
Chemistry World July 2008 Paul Docherty	Column: Totally Synthetic The target is hypocrellin A, which couldn't look much less like last month's callipeltoside A. Even a casual glance reveals one intriguing feature of this target - the fact it exists in equilibrium with an isomer.
Chemistry World September 4, 2008 Fred Campbell	Two catalysts better than one US researchers have cracked a long standing problem in chemical synthesis - the catalytic alpha-alkylation of aldehydes - by combining two catalysts in one pot.
Chemistry World January 2009 Paul Docherty	Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.
Chemistry World June 2010 Paul Docherty	Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.
Chemistry World August 2, 2013 Amy Middleton-Gear	Homogeneous catalyst made to act more like an enzyme Homogeneous catalytic systems which display selectivity in a mixture of similar substrates are rare. Now scientists have shown that encapsulating a homogeneous catalyst in a supramolecular host can give it a more discerning nature.
Chemistry World June 13, 2008 Richard Van Noorden	Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers.
Chemistry World June 19, 2008 Hepeng Jia	Chemistry dominates list of China's most influential papers The Thomson Reuters Research Fronts Award recognized a total of 24 key journal articles - including seven chemistry papers and two from the material sciences - for their outstanding contribution to international R&D.
Chemistry World February 2012 Paul Docherty	Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World March 8, 2011 Jon Cartwright	Carbon nanotubes - a boon for chiral catalysts Researchers in China have created a new catalyst that could help in the production of chiral molecules for medical drugs. The catalyst, which consists of platinum nanoparticles encapsulated in carbon nanotubes, is the most active of its type ever reported.
Chemistry World January 25, 2013 Derek Lowe	Name reactions: how does the label stick? Some of these names go back to the 19th century, and many more of them come from the first decades of the 20th. Once in a while, I wonder if the tradition is dying out. Are we still naming chemical reactions after their discoverers?
Chemistry World January 18, 2010 Phillip Broadwith	Bending the rules for arynes Two teams of synthetic and computational chemists in the US have developed complementary explanations for the unusual selectivity observed in reactions of indolynes.
Chemistry World March 10, 2006	Dual Organometallics Enhance Zinc Reactivity Chemists have synthesised organometallic compounds that enable zinc to participate in directed metalation of organic substrates.
Chemistry World July 30, 2013 Paul Docherty	Melotenine A Chirality, where would we be without you? Often the bane of the synthetic chemist's life, the challenge of asymmetry is perhaps what makes total synthesis so endlessly intriguing.
Chemistry World October 2009	Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions
Chemistry World October 1, 2012 Paul Docherty	Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.