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Chemistry World October 29, 2014	Lycopodium alkaloids Not all natural products are created equal. A glance at the total synthesis literature from the past decade is enough to discover that some molecules attract a lot more attention than others.
Chemistry World July 30, 2013 Paul Docherty	Melotenine A Chirality, where would we be without you? Often the bane of the synthetic chemist's life, the challenge of asymmetry is perhaps what makes total synthesis so endlessly intriguing.
Chemistry World January 29, 2014	Organic matter: Indoxamycins A, C and F In 2012, Erick Carreira's group in Zurich reported the total synthesis of indoxamycin B. 1 This 24-step organometallic tour de force resulted in a structural reassignment and set the bar rather high for future work on this family.
Chemistry World March 2012 Paul Docherty	Column: Totally Synthetic Ring strain is a fascinating phenomenon - one that is best understood with plastic modelling kits, wearing safety specs for ring sizes of four or less.
Chemistry World June 2011	Column: Totally Synthetic I've never heard of the Polonovski-Potier reaction, the keystone of a remarkable synthesis by a team led by Tohru Fukuyama at the University of Tokyo, Japan.
Chemistry World July 1, 2012 Paul Docherty	Vincorine Cage-structured natural products are some of the most appealing (if perhaps not appetising) targets for organic chemists -- perhaps due to their obvious intricacy of form, but also because of their structural rigidity.
Chemistry World May 2009 Paul Docherty	Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products
Chemistry World August 29, 2012 Paul Docherty	Amphidinolide F We're plunging into the marine depths to find natural products with prodigious biological activity. The amphidinolide family comprises over 30 members, varying in architecture but (almost) all featuring a complex and highly decorated macrolactone ring at the core.
Chemistry World August 30, 2007 James Mitchell Crow	Toxins' Synthesis Secret Cracked US chemists have discovered that using water instead of organic solvents is the key to understanding how algae make toxins called ladder polyethers.
Chemistry World November 27, 2012 Paul Docherty	Pentalenolactone A methyl ester One team that really gets the Pauson -- Khand reaction or the PKR and all its nuances is that led by Zhen Yang at Peking University in Beijing, China. They recently published a very neat synthesis of the intricate pentalenolactone
Chemistry World December 2009 Paul Docherty	Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A.
Chemistry World August 2008 Paul Docherty	Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses.
Chemistry World February 28, 2013 Paul Docherty	Lyconadin A Since its isolation from the clubmoss Lycopodium complanatum in 2001, lyconadina A has been party to three total syntheses. All that interest stems from anti-Alzheimer's activity attributed to the lycopodium family.
Chemistry World May 1, 2013 Paul Docherty	Kingianin A The capacity for nature to astonish me with architectural ingenuity has remained undimmed. One glance at the kingianin family of natural products did this again -- the remarkable and unusual cyclobutane functionality kindling thoughts of 'how the hell..?'
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World October 1, 2012 Paul Docherty	Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.
Chemistry World February 2010 Paul Docherty	Column: Totally Synthetic Palau'amine is an alkaloid which has stubbornly held off synthesis for over 15 years. Its nemesis comes in the form of Phil Baran at the Scripps Research Institute, La Jolla, US.
Chemistry World January 2, 2013 Paul Docherty	Flueggine A One of the most prolific sources of biologically active natural products is traditional medicines -- whose active components can be exceptionally potent. The Euphorbiaceae family of plants is a productive source of medicinal targets, including the Securinega alkaloids.
Chemistry World August 2011 Paul Docherty	Column: Totally Synthetic Yuanhuapin, a fabulously complex member of the daphnane diterpene orthoester class of natural products, bears an astonishing twelve contiguous stereogenic centres around its seven rings (look closely!).
Chemistry World May 29, 2013 Paul Docherty	Pactamycin A member of a 'rival' field stating that a molecule is 'inaccessible by synthetic organic chemistry' is like a red rag to the proverbial bull. This challenge surrounds analogs of pactamycin, a complex cyclopentane-based target with an exceptionally potent biological profile.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World February 2012 Paul Docherty	Column: Totally Synthetic Medium rings are a beguiling feature found in a host of natural products, owing to their behavioral oddities.
Chemistry World January 2009 Paul Docherty	Column: Totally Synthetic In the search for new biologically active natural products, sometimes a team isolating a new compound family will be lucky enough to find one active member.
Chemistry World July 14, 2011 Simon Hadlington	Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.
Chemistry World November 2011 Paul Docherty	Column: Totally Synthetic Gelsemoxonine has an extra four-membered azetidine ring, making for a considerable synthetic challenge.
Chemistry World August 25, 2011 David Barden	Rapid Route to Huperzine A US chemists have devised an efficient synthesis of a natural product with great potential as a protectant against chemical warfare agents and in the treatment of Alzheimer's disease.
Chemistry World July 23, 2012 Melissae Fellet	RNA wrapper protects small molecules Step aside benzene rings, there's a new protecting group in town. Dutch researchers have used a strand of RNA to cover portions of a complex small molecule. They then chemically modified a portion of the molecule not covered by the RNA.
Chemistry World March 2010 Paul Docherty	Column: Totally Synthetic Dimeric natural products are a common find, and represent a formidable challenge to synthetic chemists.
Chemistry World July 2008 Paul Docherty	Column: Totally Synthetic The target is hypocrellin A, which couldn't look much less like last month's callipeltoside A. Even a casual glance reveals one intriguing feature of this target - the fact it exists in equilibrium with an isomer.
Chemistry World October 2008 Paul Docherty	Column: Totally Synthetic Samuel Danishefsky of Columbia University (and the Sloan-Kettering Institute for cancer research), has focused on function rather than family. His many synthetic conquests are unified by their cancer-busting potential.
Chemistry World June 10, 2010 Simon Hadlington	Elusive intermediate snared Chemists in Germany have succeeded in trapping an elusive intermediate involved in a key synthetic reaction catalysed by an organic molecule.
Chemistry World April 2011 Paul Docherty	Column: Totally Synthetic Reactions in the synthesis of guanacastepene N. Discovered in fungi growing on trees in the Guanacaste conservation area in Costa Rica, several syntheses of this family have appeared in the decade since their isolation.
Chemistry World September 2010 Paul Docherty	Column: Totally Synthetic After a target has been synthesised, and the question of 'can we make this?' has been answered, perhaps the most important remaining question is 'how did nature make it?'
Chemistry World November 2010 Paul Docherty	Column: Totally Synthetic Perhaps the most familiar (and dull - they do say that familiarity breeds contempt.) chemical reaction to medicinal chemists is the amide bond formation.
Chemistry World November 2007 Dylan Stiles	Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.
Chemistry World August 2007 Derek Lowe	Opinion: In the Pipeline Process chemists just don't get the credit they deserve.
Chemistry World February 2007 Dylan Stiles	Bench Monkey There's a recurring problem in synthesis where functional groups in a molecule are prone to unwanted side reactions.
Chemistry World July 27, 2012 Paul Docherty	Marinomycin A Faced with the term 'polymer', most people would consider man-made materials, primarily plastics as typical examples. However, as in so many cases, nature was ahead of chemists, as oligomeric and polymeric materials abound in life.
Chemistry World August 2008	Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now?
Chemistry World April 2007 Derek Lowe	Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort?
Chemistry World March 2012	Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug
Chemistry World November 26, 2013 Paul Docherty	Gone to completion Where is the art of total synthesis headed?
Chemistry World October 28, 2013 Edward Anderson	More dead ends and detours en route to successful total synthesis In this book Miguel A Sierra and his co-authors revisit their 2004 coverage of 'tales of the unexpected' in complex molecule total synthesis.
Chemistry World July 7, 2011 Elinor Richards	Eight Steps to Foil Antibiotic Resistant Bacteria U.S. scientists have synthesised by a new route a key intermediate for the production of synthetic analogues of natural antibiotic tetracyclines that could be used as potential new drugs to combat the growing ranks of antibiotic resistant bacteria.