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Chemistry World January 17, 2014 Phillip Broadwith |
Plug and play redox enzymes With the constant drive to make chemical synthesis ever cleaner, more energy-efficient and generate less waste -- both in research and industrial processes -- more and more chemists are looking to harness enzyme catalysis. |
Chemistry World October 29, 2009 Lewis Brindley |
Cascading reactions in artificial cells Dutch researchers have started performing multi-step reactions inside artificial cells made from enzymes and polymers. |
Chemistry World October 16, 2015 Philippa Matthews |
One pot recipe for incompatible catalytic transformations Researchers from the US have demonstrated a new catalyst support structure allowing two incompatible catalysts to work in tandem. |
Chemistry World November 26, 2012 Laura Howes |
Protein coat prepares catalyst for cascades By protecting a transition metal catalyst with a protein coat, scientists have managed to couple up biocatalysts and chemical catalysts to perform a cascade reaction. |
Chemistry World June 17, 2010 Andrew Turley |
Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy. |
Chemistry World August 10, 2009 James Urquhart |
Stretching for reversible enzyme activation A new kind of biologically inspired nanomaterial that can be chemically turned on and off by mechanical stretching has been devised by French researchers. |
Chemistry World September 6, 2006 Michael Gross |
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. |
Chemistry World September 20, 2007 Lewis Brindley |
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. |
Chemistry World May 29, 2015 Derek Lowe |
Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways. |
Chemistry World January 3, 2012 Simon Hadlington |
One-pot synthesis creates anticancer candidates Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division. |
Chemistry World July 15, 2010 Simon Hadlington |
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. |
Chemistry World May 30, 2013 Andy Extance |
Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity. |
Chemistry World March 4, 2013 Harriet Brewerton |
Co-factoring on a chip makes biocatalysis easy Stephan Mohr and colleagues have designed an efficient microfluidic biocatalysis device that uses and regenerates an artificial mediator, dimethyl viologen, which is cheaper than co-factors used currently. |
Chemistry World January 6, 2010 Phillip Broadwith |
Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. |
Chemistry World January 30, 2015 Debbie Houghton |
Thin film approach to biocatalysis Taking an unconventional approach to biocatalysis has allowed scientists in Italy to improve enzyme recycling ability with a solvent-free reaction mixture |
Chemistry World February 21, 2007 Tom Westgate |
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. |
Chemistry World October 14, 2009 James Urquhart |
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts. |
Chemistry World March 25, 2011 Simon Hadlington |
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists. |
Chemistry World October 18, 2011 Steve Down |
Cofactor Control of Catalysis Enantioselectivity Scientists have used cofactors to control the enantioselectivity of supramolecular transition metal catalysts, enabling the asymmetric hydrogenation of a series of acrylates and related compounds with remarkably high selectivities. |
Chemistry World May 1, 2014 James Urquhart |
Ancient oceans' metals mimicked metabolism Primitive metabolism of sugar phosphates may have started spontaneously in ancient oceans around 4 billion years ago and given rise to life, according to UK researchers. |
Chemistry World February 21, 2008 Lewis Brindley |
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals. |
Chemistry World June 10, 2010 Phillip Broadwith |
A green and salty chiral catalyst An efficient, chiral, salt-based hypervalent iodine catalyst has been discovered by Japanese chemists that could replace toxic metal catalysts without generating the waste or explosion risks associated with hypervalent organo-iodine complexes. |
Chemistry World February 2011 |
Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential |
Chemistry World November 17, 2008 Simon Hadlington |
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions |
Chemistry World April 18, 2012 Elinor Richards |
Homogeneous Catalyst Recovery Made Easier Scientists have now found a way to recover homogeneous catalysts at the end of a chemical reaction that doesn't suffer from the slow reaction rates that affect current catalyst recovery systems. |
Technology Research News April 9, 2003 |
Alcohol powers fuel cell Researchers from St. University have developed a fuel cell that uses enzymes rather than metal and can be recharged by adding a few milliliters of alcohol. Biofuel cells could eventually be used as a replacement for any rechargeable power source, including laptop and PDA batteries. |
Chemistry World March 16, 2015 Elisabeth Ratcliffe |
Enzyme selectivity switch to benefit infant formula production Scientists in Austria who have redesigned the active site of an enzyme to switch its regioselectivity may have latched onto a new way to make molecules that are important for infant formula. |
Chemistry World October 31, 2013 Derek Lowe |
Natural born chemists Organic chemists may not seem like a humble group. But we should be, because we are humiliated every hour of the day by what nature accomplishes through enzyme catalysis. |
Chemistry World June 13, 2008 Richard Van Noorden |
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers. |
Chemistry World July 14, 2011 Simon Hadlington |
Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor. |
Chemistry World March 20, 2007 Tom Westgate |
Is Your Lab Ready to go Veggie? In a recently published review article, Geoffrey Cordell demonstrates that the greengrocer's could be an unexpected goldmine of sustainable, cheap reagents that would benefit chemistry in developing countries. |
Chemistry World March 31, 2014 Ian Randall |
Shifting fluids with fuel-free enzyme pumps Microscopic, non-mechanical pumps that are activated and powered by the fluids they move have been developed by researchers from the US, Russia and Puerto Rico. |
Chemistry World September 21, 2009 Hayley Birch |
Enzymes inspire new catalyst design for hydrogen production A novel enzyme-based catalyst developed by UK and US researchers hints at new ways of designing catalysts for the water-gas shift reaction, an important industrial reaction in the production of high grade hydrogen. |
Chemistry World January 27, 2010 Simon Hadlington |
Fruity route to control asymmetric syntheses Chemists in the UK have discovered a quick, cheap and easy way to make a key sulfide reagent that can mediate the formation of chirally selective molecules needed for complex organic syntheses. |
Chemistry World May 9, 2010 Phillip Broadwith |
Iron catalyst breaks the mold An iron catalyst that is not only greener than many of its precious metal competitors, but also catalyses reactions that they can't, could open new avenues in transition metal catalysis, say Chinese researchers. |
Chemistry World April 19, 2009 Hayley Birch |
Chiral metals shape up for catalysis Dutch and Israeli scientists have found a way to induce the chirality usually only found in organic materials in palladium. |
Chemistry World July 26, 2007 Tom Westgate |
Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds. |
Chemistry World November 3, 2008 Simon Hadlington |
Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple? |
Chemistry World October 2009 |
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions |
Chemistry World October 14, 2008 Simon Hadlington |
Enzymes hit with double punch US chemists have made a small molecule that simultaneously blocks two key enzymes involved in the growth of cancer cells. |
Chemistry World June 1, 2006 Michael Gross |
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions. |
Chemistry World March 8, 2011 Jon Cartwright |
Carbon nanotubes - a boon for chiral catalysts Researchers in China have created a new catalyst that could help in the production of chiral molecules for medical drugs. The catalyst, which consists of platinum nanoparticles encapsulated in carbon nanotubes, is the most active of its type ever reported. |
Chemistry World December 3, 2009 Hayley Birch |
Bio-Inspired Catalyst Design Could Rival Platinum French scientists have demonstrated the potential of a new fuel cell catalyst inspired by hydrogenase enzymes. |
Chemistry World April 25, 2014 Derek Lowe |
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. |
Chemistry World April 11, 2007 Richard Van Noorden |
Fuel Cells Guzzle Glycerol Fuel cells traditionally use oxidizing platinum catalysts to generate a flow of electrons from molecules like hydrogen or methanol. But such catalysts are expensive and can produce toxic byproducts. Now researchers are using microbial fuel cells. |
Chemistry World July 16, 2013 Harriet Brewerton |
Accelerating stereochemical analysis A chemosensor has been developed by scientists in the US to speed up the quantitative stereochemical analysis of chiral amino alcohols and diamines. |
Chemistry World September 19, 2007 Lewis Brindley |
Cell Destruction by Gel Implosion Scientists in Hong Kong have shown that creating a gel inside bacterial cells can stunt their growth. This research is a step towards developing novel treatments that would target rapidly-reproducing cells such antibiotic-resistant superbugs. |
Chemistry World February 1, 2006 Michael Gross |
Chiral Catalysis on a Chip Chiral catalysis and analytical separation of the resulting enantiomers can now be performed on a single chip. The process could be scaled up to serve in high throughput screening for new enantioselective catalysts, claim the chemists who developed the chip. |
Chemistry World March 23, 2009 Hayley Birch |
Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries. |
Chemistry World August 15, 2007 James Mitchell Crow |
From Genes to Kilos A biotechnology facility with a difference has opened on Teesside, UK - this one is open access. Its objective is to help turn bright biotech ideas into commercial success. |