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Scientific American January 2006 Charles Q. Choi |
Un-Killing the Messenger Processing bodies do more than serve as RNA trash bins in cells. Research now suggests that these P-bodies are less like junkyards and more like office centers, where messages are amassed, silenced and reactivated. |
HHMI Bulletin Winter 2013 Sarah C.P. Williams |
Cellular Search Engine Craig Mello's lab has now uncovered the reason piRNA molecules are so ubiquitous and exist in so many forms in C. elegans: so they can pair with essentially any genetic sequence they encounter during their endless scanning. |
Chemistry World August 8, 2012 |
Protein Coat for Gene Therapy Kenneth Woycechowsky's group at the University of Utah has modified a non-viral protein so that it will carry RNA. |
Chemistry World October 2, 2006 Bea Perks |
RNAi Pioneers Win Nobel Prize for Medicine Molecular biologists Andrew Fire and Craig Mello have been awarded this year's Nobel prize in physiology or medicine for their discovery of RNA interference. |
Chemistry World April 19, 2011 Simon Hadlington |
Cell factories package drugs for delivery Scientists in Australia and Germany have used living cells as 'factories' to encapsulate particles such as drugs in biological membranes. |
HHMI Bulletin May 2012 Nicole Kresge |
Locating a Genetic Glitch A team of 41 scientists led by HHMI investigator Louis Ptacek has pinpointed the gene responsible for a rare disease that causes sudden, uncontrollable movements. The culprit is a little known protein that may be responsible for communication between neurons. |
HHMI Bulletin Spring 2013 Sarah C.P. Williams |
Sounding the Alarm Details on how cells detect and respond to foreign DNA may provide clues to autoimmune diseases. |
Chemistry World June 9, 2008 Simon Hadlington |
Artificial virus silences genes Scientists in Korea have created an artificial virus that can target the nucleus of cancer cells and knock out specific genes. |
Chemistry World September 1, 2008 James Mitchell Crow |
Drug discovery on a chip Scientists in the US have, for the first time, used microfluidics to discover drug leads. The team's lab-on-a-chip device revealed inhibitors of a key membrane-bound protein in hepatitis C virus |
Technology Research News March 12, 2003 |
RNA forms nanomotor Researchers from Purdue University have constructed a tiny motor from DNA and RNA molecules. The device, fueled by ATP, which powers our own movements, could eventually power nanomachines. |
Chemistry World March 21, 2010 Simon Hadlington |
Nanoparticles successfully deliver RNA interference in cancer patients The system aims to exploit the phenomenon of RNA interference, where short sequences of double-stranded RNA, called small interfering RNA or siRNA, can trigger the disruption of the manufacture of certain proteins in a cell. |
Chemistry World July 17, 2012 Simon Perks |
Synthetic nanozymes silence hepatitis C Researchers at the University of Florida, US, have discovered that an artificial nanoparticle complex, known as a nanozyme, can help to treat viral infections by 'shutting off' their genetic material. |
Reactive Reports October 2006 David Bradley |
RNA Chemistry Zips Up Nobel Prize If Watson and Crick unlocked the mystery of DNA's structure, then Stanford University's Roger Kornberg and his team unzipped the secret of how the cell converts DNA into the RNA needed to make proteins. |
HHMI Bulletin February 2011 Sarah C.P. Williams |
Enforcing Order Changing the spatial arrangement of molecules in a cell can alter their functions. |
Chemistry World November 27, 2007 James Mitchell Crow |
A Flare for Gene Silencing US scientists have developed nanoparticle probes coated with DNA that release fluorescent 'flares' when they silence genes inside cells. |
Chemistry World August 7, 2008 Simon Hadlington |
RNA stops HIV in its tracks Scientists have successfully used a biochemical Trojan horse to smuggle killer sequences of RNA into immune cells to mug invading HIV, stopping infection in its tracks |
HHMI Bulletin February 2012 Sarah C. P. Williams |
Force Factor In the context of cells, forces are required to move molecules. Quantifying these forces gives scientists a way to compare and contrast different molecular motors. |
Wired August 2005 Jonathon Keats |
The Deadly Art of Viral Cinema Her studio is a biophysics lab, her camera a microscope. And she's changing the way we see - and fight - disease. Zhuang uses lasers, a microscope, and pair of hi-res digicams to capture viral infection in action. |
Managed Care November 2003 Thomas Morrow |
Making Sense of Antisense and Interference Treatments that interfere with protein synthesis at the cellular level will soon be debated in medical policy committee meetings. |
Chemistry World October 1, 2014 Michael Gross |
Viruses melt 'glassy' DNA US Researchers have identified the factors that enable viral DNA to turn from solid to liquid, which allows them to infect host cells. They say the process could become a target for new antiviral therapies. |
HHMI Bulletin Aug 2011 Cassandra Willyard |
A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice. |
Chemistry World June 27, 2010 Simon Hadlington |
Nanoparticles allow remote control of cells In an experiment reminiscent of the mind-control rays that featured prominently in B-movies from the 1950s, scientists in the US have used a magnetic field to alter the behavior of an animal. |
Chemistry World October 21, 2010 |
Studies Probe Key Flu Protein New details about the structure of an influenza protein that is a key drug target have been revealed in separate studies by groups in the US. The two studies provide insights into the workings of the protein machinery that the virus needs to infect cells. |
HHMI Bulletin Spring 2013 Nicole Kresge |
Use It or Lose It HHMI investigator Catherine Dulac of Harvard University has uncovered a small molecule that plays a big role in the process of tuning olfactory neurons to the environment. |
Chemistry World May 12, 2008 Simon Hadlington |
'Super-yeast' tackles unnatural proteins Researchers in the US have engineered yeast cells to produce large amounts of proteins containing unnatural amino acids (UAAs) - a feat that has previously only been possible with bacteria. |
Chemistry World April 20, 2009 James Urquhart |
New method reveals small molecule-RNA conjugates US scientists using novel chemical screening methods have discovered a new class of small molecules connected to RNA, suggesting that cellular RNA may be more chemically diverse than previously thought. |
Technology Research News January 12, 2005 |
RNA Tiles Form Nanopatterns Researchers have developed a method of coaxing artificial RNA molecules to self-assemble into specific shapes, much like a jigsaw puzzle automatically assembling. The structures could eventually be used as templates for nanochips, nanocircuits and nanocrystals |
Chemistry World February 12, 2014 Manisha Lalloo |
Synthetic strategy targets 'undruggable' small RNAs Chemists in the US have found a way to predict small molecules that can target short pieces of RNA involved in some diseases, such as cancer. |
HHMI Bulletin Spring 2013 Nicole Kresge |
A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology. |
Chemistry World October 31, 2010 Michael Gross |
Kiss of death for cancer cells Scientists have deciphered the surprising structure of the perforin pore, which delivers the 'kiss of death' to virus-infected cells and cancer cells in the body. |
HHMI Bulletin Winter 2013 Nicole Kresge |
A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure. |
Chemistry World September 23, 2009 Simon Hadlington |
Direct route to RNA sequences Scientists in the US appear to have cracked a major problem in molecular biology: how to sequence single molecules of RNA directly. |
Chemistry World October 20, 2008 Hayley Birch |
RNA computers built in yeast US scientists have assembled ribonucleic acids into an adaptable logic system that can be programmed to sense and respond to molecules inside living yeast cells. |
Chemistry World August 10, 2015 Kira Welter |
Peptide glue may have held first protocell components together Electrostatic interactions induced by short, positively charged, hydrophobic peptides are all it takes to attach RNA to vesicle membranes. |
IEEE Spectrum August 2006 Schoenbach et al. |
Zap Extreme voltage could be a surprisingly delicate tool in the fight against cancer. The list of effects that scientists have achieved using nanoseconds-long pulses is growing rapidly, though their actual use as a medical treatment is still years away. |
HHMI Bulletin February 2012 Nicole Kresge |
Protein Precision in the Brain with CSF Two causes of autism arise from opposite cellular mechanisms. Too much or too little protein production at the synapse between neurons can cause autism and intellectual disability. |
Chemistry World October 4, 2006 Bea Perks |
Good Year for RNA Roger Kornberg, professor of structural biology at Stanford University, has been awarded the 2006 Nobel prize in chemistry for his work on the molecular basis of transcription. |
Popular Mechanics September 2006 Ben Harder |
Seeking Immunity Pathogens like West Nile virus show no respect for borders. But a new class of vaccines may soon keep them in check. |
The Motley Fool July 11, 2007 Brian Orelli |
Everybody Loves RNAi Roche is the latest firm to (over)pay for the hottest new drug technology. Alnylam announced that it licensed some of its intellectual property to Roche for $331 million. Investors, take note. |
Scientific American June 2005 JR Minkel |
RNA to the Rescue The spectacular discovery that a species of plant can summon up genes its parents have lost highlights biologists' increasing recognition of RNA as a more versatile and important molecule in its own right. |
Chemistry World December 5, 2007 Ananyo Bhattacharya |
Structural Snapshot Shows Monster Protein A structural snapshot of a protein capsule has revealed details of the largest cellular component ever imaged by x-ray crystallography. |
Chemistry World January 20, 2011 Hayley Birch |
Programmable RNA promising for bio-compatible therapies Programmable nanostructures based on ribonucleic acid could be used as vessels for shipping therapeutic molecules into cells, according to US scientists. |
Chemistry World January 11, 2008 John Bonner |
DNA Nanoparticles Detect Gene Expression US scientists have made nanoparticles from DNA that they say could be used to identify the genes being expressed in a single cell. |
HHMI Bulletin Aug 2010 Richard Saltus |
Three-Dimensional Cell Cultures Thinking big but starting small, Sangeeta Bhatia is closing in on her ambitious goal: growing human livers in the lab from scratch. |
Chemistry World November 2006 Bea Perks |
Call That Chemistry? This year's Nobel prize in chemistry was a tour de force for crystallography, underscoring the vital role chemistry plays across the sciences. |
IEEE Spectrum March 2011 Lucks & Arkin |
Synthetic Biology's Hunt for the Genetic Transistor How genetic circuits will unlock the true potential of bioengineering |
Chemistry World January 31, 2008 John Bonner |
RNAi Scores Victory Against Crohn's Disease in Mice Thousands of people suffering from the debilitating gut condition Crohn's disease could experience relief from their symptoms through a technique that blocks production of a key protein in the inflammation process. |
Chemistry World March 21, 2013 Phillip Broadwith |
AstraZeneca partners with Moderna for $240 million Moderna has developed a way to use messenger RNA (mRNA), the molecule cells use to turn DNA into proteins, to stimulate the production of specific proteins in cells where disease has diminished or eliminated their ability to do so. |
Chemistry World August 15, 2007 John Bonner |
Chemists Claim Biological Alchemy South Korean chemists say they have turned muscle cells from the sole of a human foot into something akin to stem cells, using a simple molecule called neurodazine. |
Chemistry World July 6, 2007 Michael Gross |
Predicting How Proteins Fold Researchers in Italy and the UK have now developed a computational approach that can simulate the folding of membrane proteins in atomic detail. |