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HHMI Bulletin Nov 2011 Jim Keeley	Getting Back to the Bench All Janelia Farm group leaders, fellows, and junior fellows actively engage in research. They work to discover the basic rules and mechanisms of the brain's information-processing systems and developing biological and computational techniques for creating and interpreting biological images.
HHMI Bulletin Nov 2010	New live action microscopy lets scientists follow the first days of a zebrafish embryo's development The promise of live embryo imaging is unquestionable. Light-sheet microscopy will allow scientists for the first time to describe in detail the processes of development in complex vertebrates
HHMI Bulletin Fall 2012 R. John Davenport	Hanchuan Peng: SmartScopes Even when he launched his career as an engineer and computer scientist, Hanchuan Peng was drawn to the beauty of biology. He is a leader in developing sophisticated ways to make sense of biological images.
HHMI Bulletin May 2011 Corinna Wu	Mouse Cam Tracking techniques offer a long-term view into the mouse brain.
HHMI Bulletin Aug 2010 Virginia Hughes	Glimpsing Inside a Moving Fruit Fly's Brain Vivek Jayaraman wants to capture, in real time, how the fly's brain responds to a changing environment. Ultimately, he hopes to uncover very basic patterns -- "algorithms" -- of fly brain activity that hold true in more complex brains including, presumably, ours.
HHMI Bulletin Nov 2011 Jennifer Michalowski	Have Microscope, Will Travel The Bessel beam plane illumination microscope is a high-speed, high-resolution, three-dimensional imaging technology that gives extraordinarily detailed views of cellular processes in action.
HHMI Bulletin Winter 2013 Nicole Kresge	A Structural Revolution Over the years, scientists and artists have used an assortment of techniques to showcase molecular structure.
HHMI Bulletin Aug 2010 Sarah C.P. Williams	Fruit Fly Cells Don't All Know What Sex They Are HHMI scientists have now found that many cells in male and female fruit flies not only look the same, they are more identical at a molecular level than was previously thought.
HHMI Bulletin Spring 2013 Nicole Kresge	A Structural Toolbox Natalie Strynadka wants to design a better antibiotic. Her strategy: learn about the molecules bacteria use to invade cells. Her tool: structural biology.
HHMI Bulletin Nov 2011 Sarah C. P. Williams	Living Chemistry Biologists understand better what chemists can bring to the table. And chemists understand better the questions that biologists really care about. This has led to a bigger impact of chemists on biological problems.
Chemistry World January 26, 2007 Richard Van Noorden	'Ultimate Microscope' in Sight Scientists have announced a breakthrough in x-ray microscopy which could be used to picture individual atoms in living cells without using a lens.
HHMI Bulletin Fall 2012 Elise Lamar	Push and Pull Jennifer Zallen, an HHMI early career scientist at Memorial Sloan-Kettering Cancer Center, studies how embryonic tissues stretch along an anterior-posterior axis using the fruit fly Drosophila melanogaster as a model system.
HHMI Bulletin May 2010 Robert Tjian	Biomolecular Crowdsourcing A generation of web-savvy entrepreneurs has found a relatively cheap and effective approach to solving complex problems and soliciting ideas: toss out a challenge into a vibrant digital community and watch what happens.
HHMI Bulletin Nov 2011 Mitch Leslie	Creating Internal Maps Combining complementary skills, a team of neuroscientists studies how flies navigate their surroundings.
HHMI Bulletin Spring 2013 Lisa Chiu	Beautiful Beasts Igor Siwanowicz is a scientist and photographer who captures his insect subjects in extreme close-up with a digital camera and creates haunting, fluorescent images of others with a confocal microscope.
Chemistry World October 23, 2014 Simon Hadlington	New light microscope creates 3D movies inside living cells A new microscope can produce stunning, high-resolution 3D movies of processes ranging from the movement of single molecules within cells to the growth of an embryo.
HHMI Bulletin Aug 2011	Let's Get Small Tim Harris develops tools neuroscientists can use to measure the brain's activity, to give them a quantitative view inside the elaborate structure of the brain.
HHMI Bulletin May 2010 Ivan Arnato	Light Moves Light is becoming the tool of choice for researchers who want to precisely manipulate neurons and other cells.
Chemistry World October 23, 2014	The resolution revolution Super-resolution fluorescence microscopy earned three of its creators a Nobel prize this year.
Bio-IT World July 2005 Stan Schwartz	Trends in Digital Bioscience Imaging The author, a Nikon VP, reviews the improvements in digital imaging that have been achieved over the last 30 years. A new set of research tools is aimed at solving the bottlenecks commonly found in the drug discovery laboratory.
HHMI Bulletin May 2010 Jeffrey M. Perkel	A Brighter View of the Brain in Action A protein sensor is beefed up to illuminate the language of neural networks.
HHMI Bulletin May 2010 Randy Barrett	The Silicon Marvel Computational biologists have a need for speed. The computing cluster on the Janelia Farm Research Campus delivers the performance they require at a mind boggling 36 trillion operations per second.
Chemistry World January 15, 2015 Emma Stoye	Blowing up brain tissue with swelling polymer delivers sharper images A new microscopic technique that magnifies specimens by blowing them up like a balloon could make it easier to produce high resolution images of cells and tissues.
HHMI Bulletin Winter 2013 John Carey	Sydney Brenner: Model of Success At the famously innovative Medical Research Council's Laboratory of Molecular Biology in Cambridge, England, Sydney Brenner made his mark. Today, Brenner spends part of his year at Janelia, as a senior resident fellow.
IEEE Spectrum February 2011 Tekla S. Perry	Dream Jobs 2011: Insect Imagineer Gus Lott designs virtual reality systems for bugs and rats so that we can study their brains -- and ours
HHMI Bulletin Fall 2012 Madeline Drexler	The Indispensables Every research lab has behind-the-scenes specialists without whom modern science could not get done. Here are the stories of five indispensable lab team members, among many acknowledged by grateful HHMI investigators.
Bio-IT World September 16, 2004 Rabiya S. Tuma	Blinded by the Light Myriad advances in light microscopy are increasing resolution, accelerating confocality, improving detection -- and toying with the laws of nature.
Scientific American June 2008 Melinda Wenner	How Cells Make Use of Random Biochemical Reactions New studies reveal how cells exploit biochemical randomness.
Bio-IT World May 9, 2003 Vivien Marx	The Sharper Image See it, capture it, mine it, find it. The budding field of image informatics is empowering biomedical research.
Bio-IT World July 2005 David M. Evans	Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior.
HHMI Bulletin Spring 2013 Jennifer Michalowski	JAABA: Automating the Human Observer Software can be trained to recognize behaviors in several animals, including adult fruit flies, fruit fly larvae, and mice -- even by a user with no background in computer science.
Bio-IT World January 21, 2005 Mark D. Uehling	Profiling Drugs via Microscopy With robotic equipment, this Harvard team scans cells faster than researchers can blink their eyes.
Chemistry World	Fishing for Chemical Answers to Biological Questions James K. Chen talks about chemical biology, his love for the outdoors and fly fishing.
Bio-IT World December 15, 2003 Malorye A. Branca	Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.
Industrial Physicist Jennifer Ouellette	Seeing with Sound Acoustic microscopy is making inroads into areas such as materials characterization, biology, and medical diagnosis, and giving researchers yet another valuable tool in their imaging arsenal.
Chemistry World October 8, 2014	Super-resolution light microscopy wins chemistry Nobel The 2014 chemistry Nobel prize has been given to three pioneers of biomedical imaging, whose work has enabled nanoscale features within cells to be captured in exquisite detail.
HHMI Bulletin Aug 2010 Richard Saltus	Three-Dimensional Cell Cultures Thinking big but starting small, Sangeeta Bhatia is closing in on her ambitious goal: growing human livers in the lab from scratch.
IEEE Spectrum April 2013 Neil Savage	Path Found to a Combined MRI and CT Scanner Omni-tomography could add together the advantages of several medical imaging technologies
Chemistry World January 4, 2007 Henry Nicholls	Microscopic Lab Investigates Contents of a Cell It's small-scale science that could have a massive impact on research into cell biology. Scientists have produced a microscopic laboratory where they can count individual proteins in a single cell.
Chemistry World September 17, 2012 Jennifer Newton	Seeing cells under stress An analytical platform that imposes controlled mechanical strain onto live cells while monitoring changes in cell morphology and molecular signalling has been developed by scientists in Germany.
Chemistry World April 16, 2013 Emma Stoye	Polymer 'nano-suit' protects insects from vacuum Japanese scientists have shown that coating insect larvae with Tween-20, a common detergent, lets them survive the powerful vacuum inside an electron microscope. The technique could pave the way for high resolution live imaging.
HHMI Bulletin May 2011 Kathryn Brown	Mosaic Mendel Neurobiologist Julie Simpson and her partner Frank Midgley, a scientific computing expert at Janelia Farm, have created a one-of-a-kind art exhibit, "MacOSaiX Scientific Heroes."
Chemistry World December 18, 2012 Jennifer Newton	Technique to measure chemotherapy effectiveness A technique to measure how effective chemotherapy is by studying the physical changes that occur in human cells has been developed by US scientists.
Chemistry World April 24, 2012 Rebecca Brodie	Two in one technique for biological imaging A UK based team has combined two methods into a new technique to investigate cell-substrate interactions in biomedical research.
HHMI Bulletin Nov 2010	DIADEM Contest Moves Neuromapping in the Right Direction In September, DIADEM -- short for Digital Reconstruction of Axonal and Dendritic Morphology -- came to a close, with a tournament-style conclusion between five final teams taking place at HHMI's Janelia Farm Research Campus.
Bio-IT World August 13, 2002 Kevin Davies	Hughes Offers a Helping Hand Under the assured leadership of Nobel Laureate Tom Cech, the Howard Hughes Medical Institute (HHMI) is increasingly applying its considerable resources to foster imaginative, interdisciplinary biomedical research and education.
Industrial Physicist Apr/May 2003 Jennifer Oullette	Switching from physics to biology Physicists in transition help shape biological theory.
HHMI Bulletin Winter 2013 Robert Tjian	President's Letter: Taking the Long View This October, I was honored to be present at the official opening of the KwaZulu-Natal Research Institute for Tuberculosis and HIV, or K-RITH, in Durban, South Africa. This initiative brings a new dimension to HHMI's commitment to international research.
IEEE Spectrum March 2008 Susan Hassler	Winged Victory: Fly-Size Wing Flapper Lifts Off The hope is to build robotic flies that could work in any situation in which it would be better or safer to send them instead of humans.
Smithsonian June 2006 Amy Crawford	Interview: Christiane Nusslein-Volhard A Nobel laureate holds forth on flies, genes and women in science. Her first book, Coming to Life, explains the genetic and cellular basis of animal development and explores the ethical implications of recent progress in genomics and biotechnology.