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Bio-IT World April 2006 Robert M. Frederickson	High-Content Cell-Based Imaging Increasingly, equipment providers are incorporating modules for high-content and single-cell analyses into their drug discovery platforms. In addition, new strategies and equipment designs are bringing new types of analysis into the drug discovery marketplace.
Chemistry World November 1, 2013 Megan Tyler	High-throughput chip for drug screening in 3D A simple micro-array chip developed by scientists in China could sharpen the search for new drugs by enabling the high-throughput screening of drug candidates against cells cultured in three dimensions.
Bio-IT World December 15, 2003 Malorye A. Branca	Scenes from a Cell Breakthroughs are making cell-based screening faster, easier, more powerful.
Chemistry World December 22, 2009 Rajendrani Mukhopadhyay	SlipChip serves up protein crystals A simple microfluidic device requiring no pumps or valves can be used to screen for suitable protein crystallisation conditions, claim US researchers.
Chemistry World March 11, 2010 Simon Hadlington	Thalidomide Binding Protein Revealed Scientists in Japan believe they have revealed one of the key molecular targets that binds to the drug thalidomide to cause birth defects.
Bio-IT World March 2006 Robert M. Frederickson	Integration, Robotics, and Automation The integration of instruments and technology is a key concept driving the development of advanced life-sciences laboratory automation. More sophisticated robotics are also increasingly being integrated into automated systems.
Chemistry World January 14, 2010 Hayley Birch	Behavioural fingerprints point to potential drugs A novel screening method that probes the behaviour of zebrafish in response to thousands of different small molecules could help speed up the drug development process, according to US researchers.
Bio-IT World May 19, 2004 Julia Boguslavsky	Is Microfluidics Equipped for HTS? As microfluidics technologies mature and increase in throughput, they are starting to offer a highly accurate, flexible, and economical alternative to conventional high-throughput screening (HTS) platforms.
Bio-IT World September 9, 2002 John P. Helfrich	Data Management in High-Throughput Screening The high-throughput drug discovery field requires an optimal IT platform.
Bio-IT World November 12, 2002 James Golden	The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success.
Bio-IT World July 2005 David M. Evans	Cellular Imaging Takes Drug Discovery to New Heights The potential applications and ultimate value of high-content screening (HCS) and cellular image analysis are limited only by the imagination and expertise of the drug discovery groups using them to probe gene function and cell behavior.
Chemistry World November 2008 Derek Lowe	Column: In the pipeline Drug discovery chemists live by assay data; we depend on these numbers to tell us if we're heading in the right direction with our molecules.
Chemistry World November 2009 Derek Lowe	Column: In the pipeline The author advises opening your mind during the screening cascade taken by potential drug targets, and remaining goal orientated at all times
Chemistry World May 18, 2010 Sarah Houlton	EPA and pharma join forces The US Environmental Protection Agency is working with pharmaceutical companies to improve its ToxCast toxicity prediction tool.
Chemistry World September 12, 2008 Rebecca Trager	NIH funds chemical biology network NIH-funded scientists will have access to the tools for rapidly screening hundreds of thousands of small molecules against many novel biological assays at lower costs than previously possible,' said the agency's director, Elias Zerhouni.
Bio-IT World July 11, 2002 Kevin Davies	Counting the Cost of Drug Discovery Much of the trouble ensnaring the drug industry is blamed on the exorbitant cost of drug discovery. Tangible proof that the bio-IT revolution will economize drug discovery is emerging, but there is still a long way to go.
Reactive Reports Issue 41 David Bradley	Chip Chops Time off Drug Discovery Process A next-generation optical screening platform can screen a vast number of compounds rapidly by passing wave after wave of compounds in solution over the surface of the biochip.
The Motley Fool September 28, 2006 Ralph Casale	A Second Sell-Off at Molecular Devices The company, which makes equipment used in drug development, is struggling with lumpy revenues.
Bio-IT World Dec 2005/Jan 2006 Robert M. Frederickson	Labcyte Demonstrates 'Sound' Transfer As mundane as the topic of fluid management may seem, it is big business. And this developer of microfluidic systems' new technology is well suited to high-throughput biological applications where large numbers of different fluids must be transferred rapidly and sequentially.
Pharmaceutical Executive May 1, 2001	On Tour with Merck's Robots Merck's HTS robots move assay plates through the screening process.
Chemistry World January 2009 Derek Lowe	Column: In the pipeline The author discusses the age-old tradition of passing the buck in drug development.
Pharmaceutical Executive July 1, 2005 Zaborowski, Hammer & Lawler	Informatics Rules How global computer systems helped far-flung research centers at Roche work together
Bio-IT World September 2005 John Russell	BioSeek's MAP to Discovery Now, after roughly five years of platform development and building a database of assays, BioSeek seems poised for growth.
Bio-IT World September 11, 2003 Julia Boguslavsky	Cellular Screening in Sync No longer just a 'good idea,' high-content cellular screening is making an impact in target and lead selection.
Bio-IT World January 21, 2005 Robert M. Frederickson	High-Throughput Science Although genomic assays led the charge toward high-throughput science, new detection systems and formats are enabling the application of high-throughput techniques to proteins and cells.
Chemistry World July 24, 2007 Richard Van Noorden	A Viable Alternative Tests on mice, rats, rabbits and guinea pigs to stop harmful chemicals reaching humans were once a necessary evil. But such checks now seem embarrassingly old-fashioned, according to a report on toxicity testing.
Chemistry World November 2006 Derek Lowe	Opinion: In the Pipeline Is there a way to kill off bad drug candidates before companies invest valuable time and money and in them?
Chemistry World March 23, 2009 Hayley Birch	Speeding up screening for chiral catalysts U.S. researchers say their method represents a 'standard workhorse' for discovery and optimisation of chiral catalysts, such as those widely used by the pharmaceutical and pesticide industries.
Chemistry World August 29, 2008 John Bonner	Chip test for IVF embryos US researchers may have found a new way to assess the health of embryos produced by in vitro fertilization, using a lab on a chip approach to measure their uptake of nutrients.
Bio-IT World September 16, 2004 Michael A. Greeley	Platforms for Pathways Investor interest in the next great blockbuster drug has been blistering hot; Phase II and Phase III compound companies are being funded at a near record-breaking pace now that the IPO window seems to be slightly open
HHMI Bulletin May 2012 Nicole Kresge	Better Than a Straitjacket Scientist Sandhya P. Koushika devised an inexpensive, simple way to get the worms to pause so she can image cellular activity in the transparent creatures.
HHMI Bulletin Aug 2011 Cassandra Willyard	A Faster Knockout With a virus, a needle, and an ultrasound machine, researchers have drastically cut the time it takes to disable a gene in mice.
Salon.com August 21, 2000 Lori B. Andrews	Embryos under the knife The latest reproductive technology is just the next step on our sprint toward human cloning.
Salon.com December 29, 2000 Arthur Allen	Will Thompson, Bush clash over human embryo research? The HHS nominee supports it, but right-to-lifers want it stopped....
Chemistry World October 1, 2014 Katrina Kramer	Microfluidics for the masses US scientists have developed a series of microfluidic building blocks that allow researchers to construct devices by assembling the components like Lego.
Chemistry World May 2010 Derek Lowe	Column: In the pipeline The author wonders whether tagging molecules with fluorescent labels for assay is like tracking the members of a shoal of fish by tying each one to a whale. In the pharmaceutical business, our work absolutely lives and dies by assay results.
Bio-IT World August 18, 2004 Robert M. Frederickson	Channeling HPLC Thoughts of high-throughput science has been a much broader trend toward high-throughput research and miniaturization, particularly in the pharmaceutical industry and in clinical medicine. Miniaturizing high-performance liquid chromatography (HPLC) makes it cheaper and faster.
Wired January 2004 Wendy Goldman Rohm	Seven Days of Creation The inside story of a human cloning experiment
Wired June 2005 Clive Thompson	How to Farm Stem Cells Without Losing Your Soul A solution to the stem cell dilemma that even the Vatican can love.
Chemistry World October 7, 2015 Christopher Barnard	Microfluidic device lets the drop beat Scientists in Switzerland have incorporated pulsing human heart tissue into a microfluidic device to make a model of a living system that could be used to test new drugs.
Chemistry World December 6, 2012 Elinor Hughes	Stopping endocrine disruptors in their tracks US scientists have come up with a system to assess whether chemists' latest synthetic product is an endocrine disruptor -- a chemical that interferes with hormone regulation in animals and humans.
Chemistry World	Fishing for Chemical Answers to Biological Questions James K. Chen talks about chemical biology, his love for the outdoors and fly fishing.
HHMI Bulletin Nov 2010	New live action microscopy lets scientists follow the first days of a zebrafish embryo's development The promise of live embryo imaging is unquestionable. Light-sheet microscopy will allow scientists for the first time to describe in detail the processes of development in complex vertebrates
Chemistry World April 2009 Derek Lowe	Column: In the pipeline The author considers the problems of addressing drug development out of sequence
The Motley Fool September 6, 2007 Rick Aristotle Munarriz	Britain Unleashes the Wolfman The chimerical future is here. Britain's Human Fertilization and Embryo Authority announced that it will permit scientists to create human-animal hybrid embryos.
Chemistry World December 16, 2013 Michael Parkin	1024 samples analysed on a single chip Researchers in Switzerland have developed a microfluidic platform able to measure four protein biomarkers in over 1000 blood samples on a single microfluidic chip.
Geotimes October 2006 Kathryn Hansen	Fossil Embryos Exposed in 3-D For the first time, advanced X-ray imaging technology has captured a 3-D look inside tiny fossil embryos, revealing details that confirm one animal's place on the evolutionary tree.