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Chemistry World December 17, 2009 Simon Hadlington	Single catalyst gives two products from racemic mixture Chemists in the US have demonstrated a remarkable reaction in which a single catalyst can transform a racemic mixture - molecules identical in every way except for their chirality - into two distinct enantiomerically pure products.
Chemistry World December 10, 2008 Simon Hadlington	Alcohol enantiomer conundrum cracked UK chemists have discovered a straightforward new way to make chiral tertiary alcohols that gives selective access to either enantiomer.
Chemistry World February 19, 2010 Simon Hadlington	Forcing stereoselectivity on reactive cations Chemists in the US have devised a dual catalyst strategy to tame the highly reactive iminium ion to give a high degree of stereochemical control over subsequent reactions of the ion.
Chemistry World September 10, 2014 Andy Extance	'Assembly line' sculpts carbon chains UK chemists have devised a precise process for building carbon chains a link at a time that packs in more side groups than biologically-derived molecules can.
Chemistry World March 25, 2011 Simon Hadlington	New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists.
Chemistry World September 20, 2007 Lewis Brindley	New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction.
Chemistry World February 21, 2007 Tom Westgate	Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules.
Chemistry World June 2010 Paul Docherty	Column: Totally Synthetic Although its chemistry is mature and varied, my use of silicon reagents in my synthetic forays has been limited to a somewhat clumsy use of hydroxyl protecting groups.
Chemistry World November 24, 2006 Richard Van Noorden	Cooking up Nano-Fusilli Here's a new twist on nanotubes: chemists have found a set of organic molecules that spontaneously assemble themselves into a helical spiral with a hollow core.
Chemistry World September 6, 2006 Michael Gross	Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses.
Chemistry World January 14, 2015 Karl Collins	Alkynes reverse reactivity Coupling together thiols and alkynes -- both inherently nucleophilic species -- is a tricky prospect.
Chemistry World May 29, 2015 Derek Lowe	Magic molecule modifiers The synthesis of a new organic molecule can be approached in several ways.
Chemistry World January 9, 2014 James Urquhart	Simple route to add nitrogen to drugs US researchers have discovered a simple one-pot, scaleable way to synthesize aziridines -- three-membered rings that are important building blocks for introducing nitrogen into more complex molecules, including medicinal drugs.
Chemistry World July 9, 2012 Phillip Broadwith	'Molecular cobra' turns C-H to C=C A reagent developed by US chemists can selectively introduce synthetically useful C=C double bonds into unactivated carbon chains, guided by an activating group attached to a nearby oxygen or nitrogen atom.
Chemistry World January 29, 2014 Elisabeth Ratcliffe	Flow system overcomes reagent incompatibility issues Synthesizing cyclic carbonates could become easier and more efficient thanks to a sequential flow system developed by scientists in the US.
Chemistry World February 4, 2011 Elinor Richards	Strychnine in just six steps Strychnine, best known as a poison but also used medicinally as a stimulant, can now be synthesised in just six steps, say US scientists.
Chemistry World February 2011	Column: In the pipeline Enzymes have been giving chemists inferiority complexes since day one, says Derek Lowe. But there's no denying their potential
Chemistry World February 2008 Dylan Stiles	Column: Bench Monkey Cast a skeptical eye over new ideas in chemistry.
Chemistry World July 14, 2011 Simon Hadlington	Natural Products Made Via a Single Parent Molecule Chemists in the US have taken inspiration from nature to devise a new concept for rapidly and efficiently synthesising structurally diverse natural products from a single common precursor.
Chemistry World October 1, 2012 Paul Docherty	Prostaglandin F2I There's been no shortage of grant funding for synthetic chemistry of the prostaglandins, keeping some of the finest minds in organic chemistry engaged over the last five decades.
Chemistry World November 2007 Dylan Stiles	Column: Bench Monkey Total synthesis is not immune to the vagaries of fickle fashion.
Chemistry World April 25, 2014 Derek Lowe	Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found.
Chemistry World October 2009	Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions
Chemistry World May 15, 2014 Jenifer Mizen	Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses.
Chemistry World November 3, 2008 Simon Hadlington	Organic synthesis set for auto-pilot Peptides are routinely made by machines that couple together amino acid components. Could organic synthesis ever get this simple?
Chemistry World June 13, 2008 Richard Van Noorden	Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers.
Chemistry World June 12, 2015 Tim Wogan	New synthesis heralds low-cost quantum dots Quantum dots could become commonplace in display screens thanks to a new synthesis technique that should make them cheaper
Chemistry World January 21, 2013 Michael Parkin	Flow synthesis for anticancer drug UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesize the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec.
Chemistry World May 2009 Paul Docherty	Column: Totally Synthetic After a glorious 1980s and 90s as the pin-ups of total synthesis, it seems that the macrolides are now passe, and all the cool kids have moved on to work on alkaloid natural products
Chemistry World March 17, 2015 Andy Extance	Reaction map suggests meteorite chemistry route to life UK chemists have found a reaction network that they believe shows that 'pretty much everyone' working on life's molecular origins is wrong -- but also 'right, in a sense'.
Chemistry World November 15, 2011 Phillip Broadwith	Creating a toolbox for nanoparticle synthesis Hybrid nanoparticles made from several different materials that can be built up in a controlled and directed manner have been created by chemists in the US.
Chemistry World May 30, 2013 Andy Extance	Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity.
Chemistry World April 11, 2014	The sultan of synthesis Phil Baran is spurring organic chemists to rethink how they make complex compounds, as Mark Peplow discovers
Chemistry World August 12, 2015 Matthew Gunther	Chemists hold a candle to reagent preservation Scientists in the US now have a solution to end the build-up of chemical waste with a wax capsule that can protect reagents from the atmosphere.
Reactive Reports Issue 31 David Bradley	Ammonia for the primordial brew A newly discovered nitrogen-fixation reaction may have played a role in the emergence of life, according to German researchers.
Chemistry World July 2009 Paul Docherty	Column: Totally Synthetic When it comes to making large natural products, different researchers will often propose identical 'end-game' strategies to complete the target.
Chemistry World March 2009 Paul Docherty	Column: Totally Synthetic Marine waters have produced some of the biggest celebrities of the natural product world - including the brevitoxins, saxitoxins and tetrodotoxins, 1 famous as much for the sheer human effort needed for their landmark syntheses as for their complexity and size.
Chemistry World November 16, 2012 Yuandi Li	(+)-Myrrhanol C made Spanish chemists have completed the stereospecific total synthesis of (+)-myrrhanol C. This compound is a natural triterpene isolated from mastic gum, a substance well known for its medicinal properties as well as use in various cuisines.
Chemistry World December 2009 Paul Docherty	Column: Totally Synthetic What turns a good synthesis into a great synthesis are the steps surrounding that motif, something that Darren Dixon from the University of Oxford, UK, exemplifies with this synthesis of Nakadomarin A.
Chemistry World March 2, 2011 Sarah Corcoran	Natural products go with the flow Technology that could bring flow chemistry into the domain of complex natural product synthesis has been developed by UK scientists.
Chemistry World May 2010 Paul Docherty	Column: Totally Synthetic In the case of englerin A, the synthetic strategies used by Dawei Ma's group at the Chinese Academy of Sciences, Shanghai, China, 1 and Antonio Echavarren's team at Rovira and Virgili University, Tarragona, Spain, 2 are extremely similar.
Chemistry World October 15, 2012 John Hayward	Oxidizing agents Oxidation in Organic Synthesis by V.K .Ahluwalia contains an extensive list of reagents and is of some interest as a reference resource, particularly with respect to some of the more exotic reagents.
Chemistry World April 2010 Paul Docherty	Column: Totally Synthetic When one attempts the first synthesis of a natural product, the set of challenges are often unknown; which intermediates are either inaccessible or unstable, for instance.
Chemistry World October 31, 2012 Paul Docherty	Epicoccin G The class of natural products known as 2,5-diketopiperazines is both broad and synthetically well-trodden. An important sub-class of these targets are found with a sprinkling of sulfur atoms, and seem particularly well-suited to pathogen-bashing.
Chemistry World July 24, 2009 Nina Notman	Chiral isotropic liquids from achiral molecules Boomerang-shaped liquid crystal phase molecules that don't exhibit 'handedness' (chirality) have been found to form unusual chiral structures that spontaneously separate into left- and right-handed domains.
Chemistry World November 2010 Paul Docherty	Column: Totally Synthetic Perhaps the most familiar (and dull - they do say that familiarity breeds contempt.) chemical reaction to medicinal chemists is the amide bond formation.
Geotimes October 2004 Laura Stafford	Volcanic gas and early life Researchers have combined carbonyl sulfide with free amino acids in a reaction that created di-, tri- and tetra-peptides. The experiment was conducted under a variety of conditions meant to simulate Earth's early atmosphere.
Chemistry World April 19, 2009 Hayley Birch	Chiral metals shape up for catalysis Dutch and Israeli scientists have found a way to induce the chirality usually only found in organic materials in palladium.
Chemistry World August 2008 Paul Docherty	Column: Totally Synthetic Impersonating nature isn't easy, and biomimetic syntheses are remarkable in two senses.
Chemistry World February 6, 2014 Simon Lewis	Design and strategy in organic synthesis In this comprehensive treatise by Hanessian and others, a wide range of total syntheses from many different laboratories is used to exemplify different approaches to synthetic design.