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Chemistry World
August 2008
Column: In the pipeline Problems develop when there are too few workhorse reactions, which may well generate compounds that are too similar to each other. Are we at that stage now? mark for My Articles similar articles
Chemistry World
October 2010
Column: In the pipeline Derek Lowe investigates the comeback combinatorial chemistry has made in the field of drug discovery mark for My Articles similar articles
Chemistry World
September 2008
Derek Lowe
Column: In the pipeline The author remembers leaving the ivory towers of academe to trade 'unusual and beautiful' for 'useful' mark for My Articles similar articles
Chemistry World
October 2009
Column: In the pipeline Derek Lowe discusses the problem of leaning too heavily on favorite reactions mark for My Articles similar articles
Chemistry World
August 2007
Derek Lowe
Opinion: In the Pipeline Process chemists just don't get the credit they deserve. mark for My Articles similar articles
Chemistry World
June 2008
Sarah Houlton
Breaking the rules The author finds out about some chemical tricks that can give a new drug the best possible odds of success mark for My Articles similar articles
Chemistry World
November 2006
Yfke Hager
Careers: Heartfelt Chemistry After working in New Zealand, medicinal chemistry tempted Ashley Jarvis back to the UK. He now works in his dream field. mark for My Articles similar articles
Bio-IT World
September 9, 2002
John P. Helfrich
Data Management in High-Throughput Screening The high-throughput drug discovery field requires an optimal IT platform. mark for My Articles similar articles
Chemistry World
April 2011
Molecular Obesity is Weighing Down Drug Discovery Medicinal chemistry's quest for potent drug candidates has resulted in molecules that are too large and too lipophilic for their own good. mark for My Articles similar articles
Chemistry World
February 2009
Derek Lowe
Column: In the pipeline How important is it to have the best equipped lab? One group holds that there's little effect at all, that good scientists can do good work with whatever's at hand. mark for My Articles similar articles
Bio-IT World
July 11, 2002
Kevin Davies
Counting the Cost of Drug Discovery Much of the trouble ensnaring the drug industry is blamed on the exorbitant cost of drug discovery. Tangible proof that the bio-IT revolution will economize drug discovery is emerging, but there is still a long way to go. mark for My Articles similar articles
Chemistry World
March 2008
Derek Lowe
Column: In the Pipeline How to revive some lost chemistry techniques. mark for My Articles similar articles
Bio-IT World
November 2006
Kevin Davies
Jubilant Curries Favor with BioPharma The explosion of drug discovery and development operations in India is epitomized by the success of several companies. Quietly building on a decade of experience in computational and bio-IT fields, JBL is rapidly pushing into a suite of drug discovery and development activities. mark for My Articles similar articles
Chemistry World
July 30, 2015
Derek Lowe
A precision instrument? How much do medicinal chemists and their biology colleagues really trust each other's data? In the end, they have to, because drug discovery is a team sport. mark for My Articles similar articles
Chemistry World
November 25, 2014
James Urquhart
Nanomolar chemistry enables 1500 experiments in a single day Chemists have conducted over 1500 chemistry experiments in under a day thanks to a miniaturized, high throughput automation platform they developed for identifying how synthetic molecules react under various conditions. mark for My Articles similar articles
Bio-IT World
April 2007
Vicki Glaser
Software Solutions for Medicinal Chemistry Driven by advances in chemical synthesis, instrumentation, and high-throughput and high-content screening technology, medicinal chemistry's transition from an art to a science is benefiting from a wealth of new software products, spanning both bio- and cheminformatics. mark for My Articles similar articles
Chemistry World
August 2009
Derek Lowe
Column: In the pipeline The author considers what makes a good looking drug molecule - and how beauty is in the eye of the beholder mark for My Articles similar articles
Chemistry World
July 2008
Kevin Rogers
What future for small molecule therapy? Pharmaceutical companies overlook bench chemists at their peril mark for My Articles similar articles
Bio-IT World
March 2006
Robert M. Frederickson
Integration, Robotics, and Automation The integration of instruments and technology is a key concept driving the development of advanced life-sciences laboratory automation. More sophisticated robotics are also increasingly being integrated into automated systems. mark for My Articles similar articles
Bio-IT World
January 13, 2003
John Dodge
Talent Fuels Drug Pipeline in Swiss Time The functional genomics group has emerged as a critical link in the drug discovery chain at Novartis Pharmaceuticals Corp. While it employs a multidisciplinary approach to drug discovery, the four-year-old group's goals could not be simpler: Find novel drug targets. mark for My Articles similar articles
Chemistry World
August 2010
Column: In the pipeline Derek Lowe reminisces about lost laboratory techniques and wonders which will be next to go mark for My Articles similar articles
Chemistry World
December 2007
Derek Lowe
Column: In the Pipeline The challenge of biologics. mark for My Articles similar articles
The Motley Fool
August 17, 2010
Brian Orelli
Forget About This Drug Saving the Company Lilly's Alzheimer's drug fails hard. mark for My Articles similar articles
Chemistry World
December 2008
Column: In the pipeline I've worked on two drug discovery efforts (one right after the other, as fate would have it) whose final compounds differed by essentially one methyl group from the starting points of each project. mark for My Articles similar articles
Chemistry World
June 2011
Column: In the pipeline Chemists are human. Humans are hierarchical. Therefore...well, therefore, you'll find a number of different roles and levels for scientists in a drug company's labs. Here's a rough ordering, from least experienced to most. mark for My Articles similar articles
CIO
October 15, 2001
Stephanie Overby
Drug Companies on speed The marriage of IT and medical research may be just what traditional pharmaceutical companies need to survive in an increasingly competitive field. Learn how IT is bringing the pharmaceutical industry into the information age... mark for My Articles similar articles
The Motley Fool
November 26, 2007
Brian Lawler
Biogen Plays Deal Maker Biogen Idec signs a drug development deal with Swiss-based Neurimmune Therapeutics worth up to $380 million. Investors, take note. mark for My Articles similar articles
Bio-IT World
November 14, 2003
Malorye Branca
Genomics Provides the Kick Inside New tools and business structures show signs of plumping early-stage pipelines. mark for My Articles similar articles
Chemistry World
June 20, 2013
Jim Al-Khalili
Change: the only constant Today, there is much interest in a wide range of biological phenomena that may have a quantum origin, from our sense of smell to photosynthesis and mutations in DNA. mark for My Articles similar articles
The Motley Fool
February 8, 2005
Charly Travers
Investing in a Cure Drugs in the pipeline offer potential breakthroughs for Alzheimer's disease. Instead of investing in small biotechs that have a lot riding on a single Alzheimer's program, the best way to invest in the field is through a diversified company mark for My Articles similar articles
The Motley Fool
January 12, 2005
Charly Travers
Alzheimer's Drug on the Horizon? Myriad Genetics' innovative technology creates an investment opportunity. mark for My Articles similar articles
Chemistry World
December 2006
Derek Lowe
Opinion: In the Pipeline A look at the story behind the growing investment by western companies in medicinal chemistry research in China. mark for My Articles similar articles
Chemistry World
April 2007
Derek Lowe
Opinion: In the Pipeline Natural products can be ridiculously complicated. The sheer difficulty of the enterprise is traditionally what made pharmaceutical companies hire people who had worked in total synthesis. But, is total synthesis research still worth the effort? mark for My Articles similar articles
Bio-IT World
May 7, 2002
Anthony Strattner
Molecular Machining Blending nanotechnology with bioengineering, researchers at engeneOS use genomic information as engineerable parts to build biomolecules. mark for My Articles similar articles
Chemistry World
July 2010
Column: In the pipeline Derek Lowe ponders the possibility of phosphatase inhibitors mark for My Articles similar articles
Pharmaceutical Executive
May 1, 2001
On Tour with Merck's Robots Merck's HTS robots move assay plates through the screening process. mark for My Articles similar articles
Bio-IT World
November 12, 2002
Michael Goldman
A Virtual Pharmacopeia Computational modeling of disease pathways, organs --- even patients --- could transform drug discovery. Does salvation exist in silico? mark for My Articles similar articles
Chemistry World
November 27, 2013
Derek Lowe
Rolling boulders uphill A lot of preclinical projects don't even get off the ground, and many that do still never deliver anything to the development groups. mark for My Articles similar articles
Chemistry World
November 28, 2013
Put the chemistry back in medicinal chemistry Today, synthetic skill is valued and appreciated much less in medicinal chemistry than in chemical development, though it is equally important for both. Much of the blame lies with the mismeasurement of productivity. mark for My Articles similar articles
Chemistry World
March 2010
Derek Lowe
Column: In the pipeline The author takes a tour of the 'storage graveyard' where instruments that aren't useful or are too fiddly are doomed to end up mark for My Articles similar articles
Chemistry World
September 9, 2011
James Mitchell Crow
High-throughput catalyst screening for the masses Using nothing more than the standard chemistry lab equipment, researchers in the US have successfully turned the discovery of new catalytic reactions into a high-throughput process. mark for My Articles similar articles
Chemistry World
March 2011
Column: In the pipeline Drug discovery is an inherently risky business. Derek Lowe tries to balance some of the risk equations mark for My Articles similar articles
Chemistry World
April 2009
Derek Lowe
Column: In the pipeline The author considers the problems of addressing drug development out of sequence mark for My Articles similar articles
Chemistry World
August 1, 2012
Patrick Walter
Phenomenal Olympic science legacy (or is that sustainability?) What do you do with a lab set up solely to catch Olympic drug cheats once the games are over? In the case of the London 2012 games, the answer is to turn it into a state of the art analytical lab. mark for My Articles similar articles
Reactive Reports
Issue 74
David Bradley
Reactive Profile--Noel O'Boyle Interview with a Postdoctoral Research Associate in the Development Group working on drug discovery, protein-ligand docking, cheminformatics, QSAR, and computational chemistry. mark for My Articles similar articles
Bio-IT World
October 2005
Robert M. Frederickson
Nanoflow Enhances LC Devices New flow control systems save time while offering higher precision and sensitivity that are key to better comparative proteomic data coming out of liquid chromatography-mass spectronomy applications as well as more traditional clinical and diagnostic analyses. mark for My Articles similar articles
Bio-IT World
November 12, 2002
James Golden
The Business of Bioinformatics The industry has reached an interesting crossroads. As an academic branch of learning, bioinformatics remains mostly what it always was, a cross-disciplinary endeavor between computer science and molecular biology. But bioinformatics as a money-making proposition has different criteria for success. mark for My Articles similar articles
Chemistry World
March 2012
Lead-oriented synthesis Ian Churcher and Alan Nadin call for the development of more robust synthetic tools to improve small molecule survival rates in the perilous journey from lead to drug mark for My Articles similar articles
Chemistry World
June 2010
Column: In the pipeline Derek Lowe looks into his crystal ball to see what the future of medicinal chemistry might be mark for My Articles similar articles
HHMI Bulletin
Nov 2011
Sarah C.P. Williams.
Carolyn Bertozzi: Changed Expectations Chemists trained in biology were once a rarity -- now they're becoming the norm. mark for My Articles similar articles