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Chemistry World
July 16, 2013
Harriet Brewerton
Accelerating stereochemical analysis A chemosensor has been developed by scientists in the US to speed up the quantitative stereochemical analysis of chiral amino alcohols and diamines. mark for My Articles similar articles
Chemistry World
May 26, 2015
Victoria Richards
Crystalline sponge method strikes again Scientists from Japan report that their revolutionary crystallographic technique has determined the stereochemistries of molecules with axial and planar chiralities, where classical methods had failed. mark for My Articles similar articles
Chemistry World
June 5, 2012
Simon Perks
Chiral separation with micro-flows How do you separate enantiomers without any kind of chiral recognition between molecules? The answer it seems is to use asymmetric flow in a micro-fluidic channel. mark for My Articles similar articles
Chemistry World
September 20, 2007
Lewis Brindley
New Catalyst Rings the Changes Organic chemists in the US have developed a method to control the stereochemistry of a useful intramolecular Diels-Alder reaction. mark for My Articles similar articles
Chemistry World
May 30, 2013
Andy Extance
Catalyst duo exerts powerful stereocontrol Chemists from the Swiss Federal Institute of Technology, ETH Zurich, have teamed chiral catalysts in pairs to selectively drive a reaction towards desired stereoisomeric products with high selectivity. mark for My Articles similar articles
Chemistry World
September 6, 2006
Michael Gross
Selective Shortcut Chemists have developed a simple catalyst that speeds up the synthesis of a chiral protected building block used in many complex syntheses. mark for My Articles similar articles
Chemistry World
October 18, 2011
Steve Down
Cofactor Control of Catalysis Enantioselectivity Scientists have used cofactors to control the enantioselectivity of supramolecular transition metal catalysts, enabling the asymmetric hydrogenation of a series of acrylates and related compounds with remarkably high selectivities. mark for My Articles similar articles
Chemistry World
June 13, 2008
Richard Van Noorden
Asymmetric ketone catalysis gets pharma-scale makeover An asymmetric catalysis reaction limited to laboratory syntheses has received a makeover that could see it used on a large scale by drug-makers. mark for My Articles similar articles
Chemistry World
June 17, 2009
Hayley Birch
Acrylic beads promise scalable organocatalyst production Norwegian scientists have developed a new, more efficient approach to synthesizing polymer beads containing proline and its derivatives, for use in organocatalysis. mark for My Articles similar articles
Chemistry World
May 31, 2009
Nina Notman
The natural approach to winning at drug discovery High throughput drug screening is often described as a casino, with the odds stacked on the side of success as long as a big enough library is used. mark for My Articles similar articles
Chemistry World
July 26, 2007
Tom Westgate
Counterion Does the Twist US chemists have achieved a breakthrough in the design of catalysts that selectively produce chiral compounds. mark for My Articles similar articles
Chemistry World
February 1, 2006
Michael Gross
Chiral Catalysis on a Chip Chiral catalysis and analytical separation of the resulting enantiomers can now be performed on a single chip. The process could be scaled up to serve in high throughput screening for new enantioselective catalysts, claim the chemists who developed the chip. mark for My Articles similar articles
Chemistry World
October 14, 2009
James Urquhart
New route to amino acids US scientists have found a new way of making a class of non-natural amino acids that are widely used as components of pharmaceuticals and chiral catalysts. mark for My Articles similar articles
Chemistry World
July 15, 2010
Simon Hadlington
Synthetic enzyme catalyses Diels-Alder reaction The reaction is key to many organic syntheses and suggests that artificial enzymes could soon become part of the synthetic chemist's toolkit. mark for My Articles similar articles
Chemistry World
March 8, 2011
Jon Cartwright
Carbon nanotubes - a boon for chiral catalysts Researchers in China have created a new catalyst that could help in the production of chiral molecules for medical drugs. The catalyst, which consists of platinum nanoparticles encapsulated in carbon nanotubes, is the most active of its type ever reported. mark for My Articles similar articles
Chemistry World
February 21, 2007
Tom Westgate
Complex Organic Molecules Teamed with Iodine Chemists have developed a method for constructing complex halogen-containing organic molecules from simple compounds in a single step. The discovery could pave the way for the synthesis of many potentially useful naturally occurring molecules. mark for My Articles similar articles
Chemistry World
March 25, 2011
Simon Hadlington
New synthesis for chiral anticancer compound The promising anticancer compound nutlin-3 is likely to become more widely available to researchers thanks to a new synthetic protocol developed by US chemists. mark for My Articles similar articles
Bio-IT World
May 19, 2004
Julia Boguslavsky
Is Microfluidics Equipped for HTS? As microfluidics technologies mature and increase in throughput, they are starting to offer a highly accurate, flexible, and economical alternative to conventional high-throughput screening (HTS) platforms. mark for My Articles similar articles
Chemistry World
November 6, 2009
Phillip Broadwith
Enzyme binds both sides of the mirror European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. mark for My Articles similar articles
Chemistry World
May 15, 2012
Harriet Brewerton
Chiral Confusion Scientists in Israel have shown that non-biological chiral crystals are much more abundant than previously thought and their findings could clear up a possible confusion over the term 'chiral'. mark for My Articles similar articles
Chemistry World
March 28, 2007
Victoria Gill
New Limits Set on Chirality Researchers have set a new standard in stereochemistry. Measuring Raman optical activity, they have confirmed the spatial arrangement of a molecule with almost impossibly subtle chirality: (R)-[ 2H 1, 2H 2, 2H 3]-neopentane. mark for My Articles similar articles
Chemistry World
June 18, 2014
Michael Parkin
Separation by levitation A team in the US has shown that enantiopure and racemic crystals can be separated by magnetic levitation. mark for My Articles similar articles
Chemistry World
June 17, 2010
Andrew Turley
Biocatalyst improves diabetes drug production Researchers have developed an enzyme that can produce a difficult to form chiral amine in a best-selling diabetes therapy. mark for My Articles similar articles
Chemistry World
June 1, 2006
Michael Gross
New Twists on Catalysis Chemists around the world have discovered several new twists to improve the performance of asymmetric catalysts in hydrogenation reactions. mark for My Articles similar articles
Chemistry World
October 16, 2015
Philippa Matthews
One pot recipe for incompatible catalytic transformations Researchers from the US have demonstrated a new catalyst support structure allowing two incompatible catalysts to work in tandem. mark for My Articles similar articles
Chemistry World
May 2010
Derek Lowe
Column: In the pipeline The author wonders whether tagging molecules with fluorescent labels for assay is like tracking the members of a shoal of fish by tying each one to a whale. In the pharmaceutical business, our work absolutely lives and dies by assay results. mark for My Articles similar articles
Chemistry World
April 2, 2009
Ned Stafford
Fluorescent probes take screening to next level Researchers have developed a new high-throughput screening technique that could shed light on the biochemical activities of numerous proteins about which little is currently known. mark for My Articles similar articles
Chemistry World
May 9, 2010
Phillip Broadwith
Iron catalyst breaks the mold An iron catalyst that is not only greener than many of its precious metal competitors, but also catalyses reactions that they can't, could open new avenues in transition metal catalysis, say Chinese researchers. mark for My Articles similar articles
Chemistry World
September 13, 2013
Anthony King
Spinning a catalytic yarn Scientists in Germany have revealed a revolutionary new support for catalysts -- cloth. They succeeded in permanently securing organocatalysts onto nylon using ultraviolet light, without any need for chemical modification. mark for My Articles similar articles
Chemistry World
June 10, 2010
Phillip Broadwith
A green and salty chiral catalyst An efficient, chiral, salt-based hypervalent iodine catalyst has been discovered by Japanese chemists that could replace toxic metal catalysts without generating the waste or explosion risks associated with hypervalent organo-iodine complexes. mark for My Articles similar articles
Bio-IT World
August 18, 2004
Robert M. Frederickson
Channeling HPLC Thoughts of high-throughput science has been a much broader trend toward high-throughput research and miniaturization, particularly in the pharmaceutical industry and in clinical medicine. Miniaturizing high-performance liquid chromatography (HPLC) makes it cheaper and faster. mark for My Articles similar articles
Bio-IT World
September 9, 2002
John P. Helfrich
Data Management in High-Throughput Screening The high-throughput drug discovery field requires an optimal IT platform. mark for My Articles similar articles
Chemistry World
April 19, 2009
Hayley Birch
Chiral metals shape up for catalysis Dutch and Israeli scientists have found a way to induce the chirality usually only found in organic materials in palladium. mark for My Articles similar articles
Chemistry World
April 25, 2010
Hayley Birch
New strategy yields best ever catalyst for ammonia decomposition US researchers have developed a new strategy for predicting bimetallic catalysts. mark for My Articles similar articles
Chemistry World
January 6, 2010
Phillip Broadwith
Enzymes do the twist The way enzyme catalysts bind molecules to speed up their reactions is not as simple as once thought, say chemists from the UK and Spain. mark for My Articles similar articles
Chemistry World
November 28, 2013
Andy Extance
Base metal catalysts strike hydrogenation gold Three teams have shown that chemists need not rely only on expensive and toxic precious metal catalysts for hydrogenation -- they've found complementary alternatives based on cheap, abundant and safer transition metals. mark for My Articles similar articles
Chemistry World
April 14, 2011
Sarah Farley
Fish in chips: growing embryos in microfluidic systems Scientists in the Netherlands and the UK have shown for the first time that an animal embryo can develop in a microfluidic environment. mark for My Articles similar articles
Chemistry World
February 21, 2008
Lewis Brindley
Esters Made Easy with Indium Indium is the basis of a novel catalyst designed to make useful cyclic esters. This catalyst could greatly simplify the production of chiral dihydropyranones, important structural elements in many natural products and pharmaceuticals. mark for My Articles similar articles
Chemistry World
July 24, 2009
Nina Notman
Chiral isotropic liquids from achiral molecules Boomerang-shaped liquid crystal phase molecules that don't exhibit 'handedness' (chirality) have been found to form unusual chiral structures that spontaneously separate into left- and right-handed domains. mark for My Articles similar articles
Chemistry World
March 2, 2007
Philip Ball
Giving Life a Hand Why are proteins left-handed and nucleic acids right-handed? Once offered only a few sketchy theories, scientists have found more alternatives for creating homochirality. mark for My Articles similar articles
Chemistry World
November 17, 2008
Simon Hadlington
Catalyst flexes for extra control US chemists have developed a new type of catalyst capable of exerting high stereochemical control over olefin metathesis reactions mark for My Articles similar articles
Chemistry World
December 2006
Derek Lowe
Opinion: In the Pipeline A look at the story behind the growing investment by western companies in medicinal chemistry research in China. mark for My Articles similar articles
Chemistry World
May 15, 2014
Jenifer Mizen
Freeze-dried cells make better biocatalysts A biocatalytic cascade using mashed-up cells has overcome extraction and solubility problems associated with using enzymes in chemical syntheses. mark for My Articles similar articles
Chemistry World
September 17, 2013
Jennifer Newton
Half-mustard gas blues Scientists in the US are trying to develop a new detection system for the chemical warfare agent mustard gas. mark for My Articles similar articles
Chemistry World
July 9, 2008
James Mitchell Crow
Pharma goes green to cut costs The pharmaceutical industry's current drive to curb spending is helping to speed the adoption of green chemistry, say experts in the industry. mark for My Articles similar articles
Chemistry World
April 25, 2014
Derek Lowe
Engineering serendipity At this stage in the world of organic chemistry, you'd have to think that many of the great reactions that can be stumbled across with known reagents have probably been found. mark for My Articles similar articles
Chemistry World
November 3, 2011
Erica Wise
A Model for the Single Chirality of Life The boiling solutions in prebiotic hot springs could shed light on the emergence of a single chiral form of biomolecules in nature, say Spanish scientists. mark for My Articles similar articles
Chemistry World
March 5, 2014
Andy Extance
Rotaxanes make symmetry history A UK team has stumbled upon an efficient way to separately produce each member of an unusual mirror image pair of chemical systems that has eluded scientists for over four decades. mark for My Articles similar articles
Chemistry World
May 21, 2009
James Urquhart
Catalyst kinetics revealed French and UK scientists have developed a spectroscopy technique that has elucidated the reaction mechanism of a silver-alumina catalyst. mark for My Articles similar articles
Reactive Reports
May 2007
David Bradley
Meeting of Molecular Movie Stars New footage confirms Linus Pauling's theory of chemical bonding proposed half a century ago, and could help explain molecular recognition processes important throughout supramolecular chemistry and molecular biology. mark for My Articles similar articles